SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ljy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1ljy MGP-40
(Capra
hircus) 		5 / 12 ALA A 159
MET A 223
SER A 174
ILE A 173
LEU A 129
 None
 1.11A 1dreA-1ljyA:
undetectable		 1dreA-1ljyA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1ljy MGP-40
(Capra
hircus) 		5 / 12 ALA A 159
MET A 223
SER A 174
ILE A 173
LEU A 129
 None
 0.92A 1rx3A-1ljyA:
undetectable		 1rx3A-1ljyA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 1ljy MGP-40
(Capra
hircus) 		5 / 11 GLY A 241
ALA A 298
LEU A 282
VAL A 295
HIS A 197
 None
 1.06A 1ukbA-1ljyA:
undetectable		 1ukbA-1ljyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1ljy MGP-40
(Capra
hircus) 		3 / 3 PHE A  85
ARG A  96
ASN A  43
 None
 0.92A 1xzxX-1ljyA:
undetectable		 1xzxX-1ljyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 1ljy MGP-40
(Capra
hircus) 		4 / 7 PHE A 349
TYR A 276
TYR A 275
THR A 239
 None
 1.47A 2q6kA-1ljyA:
0.0		 2q6kA-1ljyA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 1ljy MGP-40
(Capra
hircus) 		5 / 9 TYR A   6
PHE A  37
GLY A  77
TYR A 185
TRP A 331
 None
 0.71A 2uy4A-1ljyA:
19.4		 2uy4A-1ljyA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1ljy MGP-40
(Capra
hircus) 		5 / 12 SER A 181
VAL A 157
GLN A 172
ILE A 170
HIS A 176
 None
 1.43A 2vdyA-1ljyA:
undetectable		 2vdyA-1ljyA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1ljy MGP-40
(Capra
hircus) 		5 / 10 ALA A 156
ASP A 115
LEU A  72
ILE A  34
TYR A 185
 None
 1.19A 2w9sD-1ljyA:
undetectable		 2w9sD-1ljyA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 1ljy MGP-40
(Capra
hircus) 		5 / 11 TYR A   6
PHE A  37
GLY A  77
TYR A 185
TRP A 331
 None
 0.74A 2xtkA-1ljyA:
20.5		 2xtkA-1ljyA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 1ljy MGP-40
(Capra
hircus) 		5 / 10 TYR A   6
PHE A  37
GLY A  77
TYR A 185
TRP A 331
 None
 0.80A 2xtkB-1ljyA:
20.5		 2xtkB-1ljyA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ljy MGP-40
(Capra
hircus) 		5 / 12 GLY A 167
ALA A 155
ILE A 180
LEU A 182
LEU A 183
 None
 1.02A 3adxB-1ljyA:
0.0		 3adxB-1ljyA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ljy MGP-40
(Capra
hircus) 		5 / 10 GLN A 293
VAL A 295
HIS A 197
ASP A 308
ILE A 237
 None
 1.31A 3fhjA-1ljyA:
undetectable		 3fhjA-1ljyA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ljy MGP-40
(Capra
hircus) 		5 / 10 GLN A 293
VAL A 295
HIS A 197
ASP A 308
ILE A 237
 None
 1.26A 3fhjE-1ljyA:
undetectable		 3fhjE-1ljyA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ljy MGP-40
(Capra
hircus) 		5 / 9 GLN A 293
VAL A 295
HIS A 197
ASP A 308
ILE A 237
 None
 1.30A 3fi0A-1ljyA:
undetectable		 3fi0A-1ljyA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ljy MGP-40
(Capra
hircus) 		5 / 9 GLN A 293
VAL A 295
HIS A 197
ASP A 308
ILE A 237
 None
 1.31A 3fi0H-1ljyA:
undetectable		 3fi0H-1ljyA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ljy MGP-40
(Capra
hircus) 		5 / 9 GLN A 293
VAL A 295
HIS A 197
ASP A 308
ILE A 237
 None
 1.32A 3fi0K-1ljyA:
undetectable		 3fi0K-1ljyA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ljy MGP-40
(Capra
hircus) 		5 / 9 GLN A 293
VAL A 295
HIS A 197
ASP A 308
ILE A 237
 None
 1.35A 3fi0L-1ljyA:
undetectable		 3fi0L-1ljyA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ljy MGP-40
(Capra
hircus) 		5 / 9 GLN A 293
VAL A 295
HIS A 197
ASP A 308
ILE A 237
 None
 1.26A 3fi0M-1ljyA:
undetectable		 3fi0M-1ljyA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 1ljy MGP-40
(Capra
hircus) 		4 / 4 LEU A 320
MET A 223
ILE A  34
ASP A 178
 None
 1.24A 3hecA-1ljyA:
0.0		 3hecA-1ljyA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1ljy MGP-40
(Capra
hircus) 		5 / 12 ALA A 159
MET A 223
SER A 174
ILE A 173
LEU A 129
 None
 1.03A 3ia4A-1ljyA:
undetectable		 3ia4A-1ljyA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 1ljy MGP-40
(Capra
hircus) 		5 / 12 ALA A 159
MET A 223
SER A 174
ILE A 173
LEU A 129
 None
 1.03A 3ia4B-1ljyA:
undetectable		 3ia4B-1ljyA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 1ljy MGP-40
(Capra
hircus) 		5 / 12 ALA A 159
MET A 223
SER A 174
ILE A 173
LEU A 129
 None
 1.03A 3ia4C-1ljyA:
undetectable		 3ia4C-1ljyA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 1ljy MGP-40
(Capra
hircus) 		5 / 12 ALA A 159
MET A 223
SER A 174
ILE A 173
LEU A 129
 None
 1.04A 3ia4D-1ljyA:
undetectable		 3ia4D-1ljyA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 1ljy MGP-40
(Capra
hircus) 		4 / 7 TYR A   7
ASN A  51
LEU A  55
ASP A  52
 None
 1.15A 3lslA-1ljyA:
undetectable
3lslD-1ljyA:
undetectable		 3lslA-1ljyA:
22.16
3lslD-1ljyA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 1ljy MGP-40
(Capra
hircus) 		4 / 7 TYR A   7
ASN A  51
LEU A  55
ASP A  52
 None
 1.16A 3lslA-1ljyA:
undetectable
3lslD-1ljyA:
undetectable		 3lslA-1ljyA:
22.16
3lslD-1ljyA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 1ljy MGP-40
(Capra
hircus) 		4 / 6 TYR A   7
ASN A  51
LEU A  55
ASP A  52
 None
 1.19A 3lslG-1ljyA:
undetectable		 3lslG-1ljyA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 1ljy MGP-40
(Capra
hircus) 		4 / 7 PHE A 338
ASP A 337
GLY A  18
THR A 341
 None
 1.15A 3vnsA-1ljyA:
0.7		 3vnsA-1ljyA:
22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WQV_A_GCSA501_1
(CHITINASE)		 1ljy MGP-40
(Capra
hircus) 		6 / 11 PHE A  37
GLY A  77
TYR A 185
ASP A 186
ARG A 242
TRP A 331
 None
 1.15A 3wqvA-1ljyA:
51.8		 3wqvA-1ljyA:
35.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WQW_A_GCSA501_1
(CHITINASE)		 1ljy MGP-40
(Capra
hircus) 		6 / 11 PHE A  37
GLY A  77
TYR A 185
ASP A 186
ARG A 242
TRP A 331
 None
 1.15A 3wqwA-1ljyA:
51.7		 3wqwA-1ljyA:
35.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1ljy MGP-40
(Capra
hircus) 		5 / 12 SER A 181
VAL A 157
GLN A 172
ILE A 170
HIS A 176
 None
 1.16A 4c49A-1ljyA:
0.0		 4c49A-1ljyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 1ljy MGP-40
(Capra
hircus) 		4 / 8 SER A  11
CYH A  20
PHE A 338
TYR A   7
 None
 1.21A 4j7uD-1ljyA:
undetectable		 4j7uD-1ljyA:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NSB_A_AINA402_1
(CHITINASE-3-LIKE
PROTEIN 1)		 1ljy MGP-40
(Capra
hircus) 		5 / 7 THR A   8
TRP A  10
ARG A  14
TRP A 331
LEU A 335
 None
 0.34A 4nsbA-1ljyA:
60.4		 4nsbA-1ljyA:
95.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NSB_A_AINA402_1
(CHITINASE-3-LIKE
PROTEIN 1)		 1ljy MGP-40
(Capra
hircus) 		4 / 7 THR A   8
TRP A  78
TRP A 331
LEU A 335
 None
 0.86A 4nsbA-1ljyA:
60.4		 4nsbA-1ljyA:
95.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 1ljy MGP-40
(Capra
hircus) 		5 / 12 GLY A 204
ASN A 205
ASP A 207
GLN A 294
SER A 199
 None
 1.25A 4pooB-1ljyA:
undetectable		 4pooB-1ljyA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1ljy MGP-40
(Capra
hircus) 		5 / 12 GLY A 236
ILE A 180
MET A 329
MET A 223
ALA A 159
 None
 1.08A 4qtuD-1ljyA:
undetectable		 4qtuD-1ljyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ljy MGP-40
(Capra
hircus) 		5 / 11 GLY A 167
ALA A 155
ILE A 180
LEU A 182
LEU A 183
 None
 1.05A 4xumB-1ljyA:
0.0		 4xumB-1ljyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 1ljy MGP-40
(Capra
hircus) 		4 / 8 PHE A  37
TRP A  78
TRP A 331
TYR A 185
 None
 1.44A 5amkA-1ljyA:
undetectable		 5amkA-1ljyA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1ljy MGP-40
(Capra
hircus) 		4 / 5 THR A 286
ALA A 298
THR A 299
HIS A 288
 None
 1.27A 5ecmA-1ljyA:
0.2		 5ecmA-1ljyA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 1ljy MGP-40
(Capra
hircus) 		5 / 12 GLY A 261
GLY A 271
GLY A 241
GLU A 269
ILE A 262
 None
 1.01A 5ehiC-1ljyA:
undetectable		 5ehiC-1ljyA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 1ljy MGP-40
(Capra
hircus) 		5 / 8 PHE A  37
GLY A  77
TYR A 185
ARG A 242
TRP A 331
 None
 0.99A 5gqbA-1ljyA:
43.3		 5gqbA-1ljyA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 1ljy MGP-40
(Capra
hircus) 		4 / 7 PRO A 121
TYR A 168
PHE A  85
SER A  74
 None
 1.14A 5l1fC-1ljyA:
2.3		 5l1fC-1ljyA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1ljy MGP-40
(Capra
hircus) 		3 / 3 LYS A 356
LEU A 333
ASP A  26
 None
 0.84A 5zv2A-1ljyA:
undetectable		 5zv2A-1ljyA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 1ljy MGP-40
(Capra
hircus) 		3 / 3 ALA A 216
PHE A 202
GLN A 294
 None
 0.83A 6eceA-1ljyA:
2.5		 6eceA-1ljyA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 1ljy MGP-40
(Capra
hircus) 		5 / 12 MET A 235
MET A 329
ALA A 328
TYR A   1
VAL A 355
 None
 1.29A 6hu9N-1ljyA:
0.0		 6hu9N-1ljyA:
20.78