SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lk3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 1lk3 9D7 HEAVY CHAIN
9D7 LIGHT CHAIN
(Rattus
norvegicus) 		6 / 12 TYR L  35
GLN L  88
LEU L  95
PHE L  97
VAL H  37
TRP H 109
 None
 0.75A 1h8sA-1lk3L:
21.6		 1h8sA-1lk3L:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1lk3 9D7 LIGHT CHAIN
(Rattus
norvegicus) 		4 / 8 HIS L  33
TYR L  35
TYR L  48
SER L  90
 None
 0.85A 1i7zA-1lk3L:
26.8		 1i7zA-1lk3L:
67.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA257_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 1lk3 9D7 LIGHT CHAIN
(Rattus
norvegicus) 		4 / 4 THR L   2
ALA L  24
GLN L  89
MET L  32
 None
 0.91A 1jgsA-1lk3L:
0.0		 1jgsA-1lk3L:
22.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1lk3 9D7 LIGHT CHAIN
(Rattus
norvegicus) 		4 / 5 TYR L  35
GLN L  88
LEU L  95
PHE L  97
 None
 0.36A 3ls4L-1lk3L:
26.9		 3ls4L-1lk3L:
74.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 1lk3 9D7 HEAVY CHAIN
(Rattus
norvegicus) 		4 / 5 VAL H   2
TYR H  27
ARG H  98
TYR H 108
 None
 0.29A 4m7kH-1lk3H:
26.8		 4m7kH-1lk3H:
67.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 1lk3 9D7 HEAVY CHAIN
(Rattus
norvegicus) 		4 / 5 LEU H  20
SER H  95
LEU H 114
LEU H  83
 None
 1.28A 4n09B-1lk3H:
undetectable		 4n09B-1lk3H:
20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIL_H_QI9H1223_0
(FAB 314.1)		 1lk3 9D7 HEAVY CHAIN
9D7 LIGHT CHAIN
(Rattus
norvegicus;
Rattus
norvegicus) 		5 / 12 HIS H  35
GLY H 102
PHE H 106
GLN L  88
GLN L  89
 None
 1.17A 4uilH-1lk3H:
24.6
4uilL-1lk3H:
11.6		 4uilH-1lk3H:
75.23
4uilL-1lk3H:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 1lk3 9D7 LIGHT CHAIN
(Rattus
norvegicus) 		4 / 8 THR L  73
SER L  62
THR L  71
SER L  64
 None
 1.02A 5l4eA-1lk3L:
1.9
5l4eB-1lk3L:
3.3
5l4eC-1lk3L:
2.3
5l4eD-1lk3L:
1.6
5l4eE-1lk3L:
1.9		 5l4eA-1lk3L:
21.95
5l4eB-1lk3L:
21.95
5l4eC-1lk3L:
21.95
5l4eD-1lk3L:
21.95
5l4eE-1lk3L:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 1lk3 9D7 HEAVY CHAIN
(Rattus
norvegicus) 		4 / 5 SER H 118
ALA H 120
PHE H 152
LEU H 176
 None
 0.38A 5mthA-1lk3H:
19.8		 5mthA-1lk3H:
76.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 1lk3 9D7 HEAVY CHAIN
(Rattus
norvegicus) 		5 / 12 ALA H  16
PHE H 152
ALA H 174
LEU H 114
THR H  87
 None
 1.17A 5tl8A-1lk3H:
undetectable		 5tl8A-1lk3H:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 1lk3 9D7 HEAVY CHAIN
(Rattus
norvegicus) 		3 / 3 SER H 209
ALA H 204
VAL H 203
 None
 0.51A 5xiwC-1lk3H:
undetectable		 5xiwC-1lk3H:
15.77