SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lk5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 161
ILE A 200
GLY A 202
ILE A 141
ILE A 180
 None
 0.96A 1c6yA-1lk5A:
undetectable		 1c6yA-1lk5A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 8 ILE A 200
ILE A 138
GLU A 139
VAL A 140
ILE A 148
 None
 1.33A 1linA-1lk5A:
undetectable		 1linA-1lk5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.90A 1muiA-1lk5A:
undetectable		 1muiA-1lk5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.85A 1muiB-1lk5A:
undetectable		 1muiB-1lk5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.85A 1rl8A-1lk5A:
undetectable		 1rl8A-1lk5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.85A 1rl8B-1lk5A:
undetectable		 1rl8B-1lk5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.97A 1sduB-1lk5A:
undetectable		 1sduB-1lk5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 197
ILE A 149
VAL A 203
ILE A 200
 None
 0.79A 2aojB-1lk5A:
undetectable		 2aojB-1lk5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.85A 2aquA-1lk5A:
undetectable		 2aquA-1lk5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 11 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.89A 2aquB-1lk5A:
undetectable		 2aquB-1lk5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A 161
ILE A 200
GLY A 202
ILE A 141
ILE A 180
 None
 1.01A 2avoA-1lk5A:
undetectable		 2avoA-1lk5A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.81A 2avvB-1lk5A:
undetectable		 2avvB-1lk5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.86A 2avvE-1lk5A:
undetectable		 2avvE-1lk5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.98A 2f81A-1lk5A:
undetectable		 2f81A-1lk5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.98A 2f81B-1lk5A:
undetectable		 2f81B-1lk5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.83A 2fxeA-1lk5A:
0.0		 2fxeA-1lk5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.94A 2idwB-1lk5A:
undetectable		 2idwB-1lk5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 9 ILE A  24
ILE A  51
PHE A  35
ALA A  64
LEU A  26
 None
 1.15A 2m9qA-1lk5A:
0.0		 2m9qA-1lk5A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.88A 2o4kB-1lk5A:
undetectable		 2o4kB-1lk5A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.87A 2q64A-1lk5A:
undetectable		 2q64A-1lk5A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.87A 2qakA-1lk5A:
undetectable		 2qakA-1lk5A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.87A 2rkfB-1lk5A:
undetectable		 2rkfB-1lk5A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.86A 2rkgA-1lk5A:
undetectable		 2rkgA-1lk5A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.84A 2z54A-1lk5A:
undetectable		 2z54A-1lk5A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.94A 2z54B-1lk5A:
undetectable		 2z54B-1lk5A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		3 / 3 SER A  57
GLY A  27
GLY A  29
 CL  A1005 (-4.2A)
None
None
 0.48A 3bogA-1lk5A:
undetectable
3bogC-1lk5A:
undetectable		 3bogA-1lk5A:
undetectable
3bogC-1lk5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 207
GLY A  99
ILE A 138
LEU A  96
GLU A  89
 None
CL  A1001 (-3.6A)
None
None
None
 1.04A 3ckkA-1lk5A:
undetectable		 3ckkA-1lk5A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.94A 3d1xB-1lk5A:
undetectable		 3d1xB-1lk5A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A 161
ILE A 200
GLY A 202
ILE A 141
ILE A 180
 None
 1.05A 3d1yB-1lk5A:
undetectable		 3d1yB-1lk5A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.93A 3d20B-1lk5A:
undetectable		 3d20B-1lk5A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 8 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 1.00A 3ekpA-1lk5A:
undetectable		 3ekpA-1lk5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A 161
ILE A 200
GLY A 202
ILE A 141
ILE A 180
 None
 0.98A 3ekqB-1lk5A:
undetectable		 3ekqB-1lk5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 11 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.96A 3ektD-1lk5A:
undetectable		 3ektD-1lk5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.84A 3ekwB-1lk5A:
undetectable		 3ekwB-1lk5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.90A 3ekyA-1lk5A:
undetectable		 3ekyA-1lk5A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 11 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.91A 3el1A-1lk5A:
undetectable		 3el1A-1lk5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.88A 3el1B-1lk5A:
undetectable		 3el1B-1lk5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.92A 3lzsB-1lk5A:
undetectable		 3lzsB-1lk5A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.89A 3lzuA-1lk5A:
undetectable		 3lzuA-1lk5A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.97A 3nduB-1lk5A:
undetectable		 3nduB-1lk5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.76A 3ndwA-1lk5A:
undetectable		 3ndwA-1lk5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.76A 3ndxA-1lk5A:
undetectable		 3ndxA-1lk5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.93A 3nujB-1lk5A:
undetectable		 3nujB-1lk5A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 9 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.92A 3nuoB-1lk5A:
undetectable		 3nuoB-1lk5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 VAL A 127
LEU A 130
VAL A 119
GLY A  86
ALA A  87
 None
 1.11A 3rr3C-1lk5A:
undetectable		 3rr3C-1lk5A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 VAL A 127
LEU A 130
VAL A 119
GLY A  86
ALA A  87
 None
 1.11A 3rr3D-1lk5A:
undetectable		 3rr3D-1lk5A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.93A 3tkgA-1lk5A:
undetectable		 3tkgA-1lk5A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.90A 3tkwA-1lk5A:
undetectable		 3tkwA-1lk5A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.96A 3ttpA-1lk5A:
0.0		 3ttpA-1lk5A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.93A 3ttpB-1lk5A:
0.0		 3ttpB-1lk5A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 9 ALA A 147
ILE A 200
GLY A 202
ILE A 141
LEU A 161
 None
 1.10A 3u7sB-1lk5A:
undetectable		 3u7sB-1lk5A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 9 ALA A 147
ILE A 200
GLY A 202
ILE A 141
LEU A 161
 None
 0.95A 3u7sA-1lk5A:
undetectable		 3u7sA-1lk5A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 149
LEU A 152
VAL A 203
GLY A 202
 None
 0.86A 3w1wA-1lk5A:
undetectable		 3w1wA-1lk5A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		4 / 6 ASP A  85
THR A 116
THR A  32
PHE A  35
 None
 1.09A 4acbC-1lk5A:
undetectable		 4acbC-1lk5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.85A 4hlaA-1lk5A:
undetectable		 4hlaA-1lk5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 9 GLU A 196
ILE A 148
VAL A 203
ALA A 182
ILE A 138
 None
 1.07A 4lbgB-1lk5A:
3.3		 4lbgB-1lk5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.97A 4njvA-1lk5A:
undetectable		 4njvA-1lk5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 101
ALA A 102
GLY A 207
ILE A  97
ILE A 179
 CL  A1001 (-3.4A)
None
None
None
None
 0.90A 4njvD-1lk5A:
undetectable		 4njvD-1lk5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 208
LEU A 191
ASN A 198
ILE A 195
 None
 0.79A 4rmjA-1lk5A:
2.8		 4rmjA-1lk5A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A 161
ILE A 200
GLY A 202
ILE A 141
ILE A 180
 None
 1.00A 5kqxB-1lk5A:
undetectable		 5kqxB-1lk5A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A 161
ALA A 147
ILE A 200
GLY A 202
ILE A 141
 None
 1.06A 5kr1A-1lk5A:
undetectable		 5kr1A-1lk5A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 161
ALA A 147
ILE A 200
GLY A 202
ILE A 141
 None
 0.93A 5kr2B-1lk5A:
undetectable		 5kr2B-1lk5A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 161
ILE A 200
GLY A 202
ILE A 141
ILE A 180
 None
 1.06A 5kr2B-1lk5A:
undetectable		 5kr2B-1lk5A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A 161
ILE A 200
GLY A 202
ILE A 141
ILE A 180
 None
 1.11A 5kr2D-1lk5A:
undetectable		 5kr2D-1lk5A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 120
VAL A  84
ALA A 114
ALA A  83
GLY A  25
 None
 1.14A 5tzoB-1lk5A:
0.0		 5tzoB-1lk5A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		4 / 8 GLY A  86
ARG A 124
VAL A 121
ASP A 122
 None
 0.95A 5vlmA-1lk5A:
undetectable		 5vlmA-1lk5A:
22.50