SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lkd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		4 / 6 LEU A 197
MET A   9
LEU A  60
HIS A 210
 None
None
None
FE2  A 500 ( 3.5A)
 1.10A 1errB-1lkdA:
undetectable		 1errB-1lkdA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 12 GLU A 260
LEU A 144
GLY A 145
MET A   9
ALA A  63
 FE2  A 500 ( 2.8A)
None
None
None
None
 1.04A 1hvyD-1lkdA:
0.0		 1hvyD-1lkdA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		4 / 8 LEU A 213
VAL A 134
GLY A 136
LEU A  27
 None
 0.90A 1s1xA-1lkdA:
undetectable		 1s1xA-1lkdA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		4 / 5 LEU A 197
MET A   9
LEU A  60
HIS A 210
 None
None
None
FE2  A 500 ( 3.5A)
 1.06A 2jfaA-1lkdA:
undetectable		 2jfaA-1lkdA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A  27
ALA A 224
VAL A 221
THR A 235
HIS A 210
 None
None
None
P6G  A 600 ( 4.8A)
FE2  A 500 ( 3.5A)
 1.32A 2qo4A-1lkdA:
0.0		 2qo4A-1lkdA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A  27
ALA A 224
VAL A 221
THR A 235
HIS A 210
 None
None
None
P6G  A 600 ( 4.8A)
FE2  A 500 ( 3.5A)
 1.31A 2qo6A-1lkdA:
undetectable		 2qo6A-1lkdA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		4 / 5 LEU A 197
MET A   9
LEU A  60
HIS A 210
 None
None
None
FE2  A 500 ( 3.5A)
 1.06A 2qxsA-1lkdA:
undetectable		 2qxsA-1lkdA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		4 / 5 LEU A 197
MET A   9
LEU A  60
HIS A 210
 None
None
None
FE2  A 500 ( 3.5A)
 1.05A 2qxsB-1lkdA:
undetectable		 2qxsB-1lkdA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		4 / 5 HIS A 146
HIS A 195
VAL A 148
HIS A 210
 FE2  A 500 ( 3.5A)
BP6  A 300 (-4.2A)
BP6  A 300 (-4.4A)
FE2  A 500 ( 3.5A)
 0.99A 2wkoF-1lkdA:
undetectable		 2wkoF-1lkdA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		4 / 5 VAL A 274
VAL A 273
PHE A 187
ARG A 270
 None
None
BP6  A 300 (-4.3A)
None
 1.32A 3bjwH-1lkdA:
0.0		 3bjwH-1lkdA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		4 / 5 VAL A 274
VAL A 273
PHE A 187
ARG A 270
 None
None
BP6  A 300 (-4.3A)
None
 1.33A 3bjwB-1lkdA:
0.0		 3bjwB-1lkdA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 9 LEU A  60
PHE A  11
LEU A 144
ILE A  50
ALA A  51
 None
 1.02A 3mdvA-1lkdA:
0.0		 3mdvA-1lkdA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		4 / 4 LEU A   6
ILE A  50
GLY A 145
PHE A 211
 None
 0.92A 4dc3A-1lkdA:
undetectable		 4dc3A-1lkdA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 12 PHE A 137
LEU A 144
GLY A 145
TYR A  65
ALA A  63
 None
 1.08A 4eb4A-1lkdA:
undetectable		 4eb4A-1lkdA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 12 PHE A 137
LEU A 144
GLY A 145
TYR A  65
ALA A  63
 None
 1.07A 4eb4B-1lkdA:
undetectable		 4eb4B-1lkdA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 11 HIS A 210
TYR A 250
GLU A 260
HIS A 146
ALA A 198
 FE2  A 500 ( 3.5A)
P6G  A 600 ( 3.7A)
FE2  A 500 ( 2.8A)
FE2  A 500 ( 3.5A)
BP6  A 300 ( 4.2A)
 0.57A 4ir0A-1lkdA:
7.2
4ir0B-1lkdA:
7.5		 4ir0A-1lkdA:
17.24
4ir0B-1lkdA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 11 HIS A 146
ALA A 198
HIS A 210
TYR A 250
GLU A 260
 FE2  A 500 ( 3.5A)
BP6  A 300 ( 4.2A)
FE2  A 500 ( 3.5A)
P6G  A 600 ( 3.7A)
FE2  A 500 ( 2.8A)
 0.51A 4ir0A-1lkdA:
7.2
4ir0B-1lkdA:
7.5		 4ir0A-1lkdA:
17.24
4ir0B-1lkdA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 12 HIS A 210
TYR A 250
GLU A 260
HIS A 146
ALA A 198
 FE2  A 500 ( 3.5A)
P6G  A 600 ( 3.7A)
FE2  A 500 ( 2.8A)
FE2  A 500 ( 3.5A)
BP6  A 300 ( 4.2A)
 0.52A 4jd1A-1lkdA:
7.3
4jd1B-1lkdA:
7.3		 4jd1A-1lkdA:
17.24
4jd1B-1lkdA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 12 HIS A 146
ALA A 198
HIS A 210
TYR A 250
GLU A 260
 FE2  A 500 ( 3.5A)
BP6  A 300 ( 4.2A)
FE2  A 500 ( 3.5A)
P6G  A 600 ( 3.7A)
FE2  A 500 ( 2.8A)
 0.63A 4jd1A-1lkdA:
7.3
4jd1B-1lkdA:
7.3		 4jd1A-1lkdA:
17.24
4jd1B-1lkdA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 12 HIS A 210
TYR A 250
GLU A 260
HIS A 146
ALA A 198
 FE2  A 500 ( 3.5A)
P6G  A 600 ( 3.7A)
FE2  A 500 ( 2.8A)
FE2  A 500 ( 3.5A)
BP6  A 300 ( 4.2A)
 0.50A 4jh3A-1lkdA:
3.8
4jh3B-1lkdA:
7.2		 4jh3A-1lkdA:
17.85
4jh3B-1lkdA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 11 HIS A 146
ALA A 198
HIS A 210
TYR A 250
GLU A 260
 FE2  A 500 ( 3.5A)
BP6  A 300 ( 4.2A)
FE2  A 500 ( 3.5A)
P6G  A 600 ( 3.7A)
FE2  A 500 ( 2.8A)
 0.48A 4jh3A-1lkdA:
3.8
4jh3B-1lkdA:
7.2		 4jh3A-1lkdA:
17.85
4jh3B-1lkdA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 11 HIS A 210
TYR A 250
GLU A 260
HIS A 146
ALA A 198
 FE2  A 500 ( 3.5A)
P6G  A 600 ( 3.7A)
FE2  A 500 ( 2.8A)
FE2  A 500 ( 3.5A)
BP6  A 300 ( 4.2A)
 0.43A 4jh4A-1lkdA:
7.1
4jh4B-1lkdA:
7.0		 4jh4A-1lkdA:
17.85
4jh4B-1lkdA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 11 HIS A 146
ALA A 198
HIS A 210
TYR A 250
GLU A 260
 FE2  A 500 ( 3.5A)
BP6  A 300 ( 4.2A)
FE2  A 500 ( 3.5A)
P6G  A 600 ( 3.7A)
FE2  A 500 ( 2.8A)
 0.44A 4jh4A-1lkdA:
7.1
4jh4B-1lkdA:
7.0		 4jh4A-1lkdA:
17.85
4jh4B-1lkdA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 11 HIS A 210
TYR A 250
GLU A 260
HIS A 146
ALA A 198
 FE2  A 500 ( 3.5A)
P6G  A 600 ( 3.7A)
FE2  A 500 ( 2.8A)
FE2  A 500 ( 3.5A)
BP6  A 300 ( 4.2A)
 0.47A 4jh5A-1lkdA:
7.1
4jh5B-1lkdA:
6.2		 4jh5A-1lkdA:
17.85
4jh5B-1lkdA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 11 HIS A 146
ALA A 198
HIS A 210
TYR A 250
GLU A 260
 FE2  A 500 ( 3.5A)
BP6  A 300 ( 4.2A)
FE2  A 500 ( 3.5A)
P6G  A 600 ( 3.7A)
FE2  A 500 ( 2.8A)
 0.48A 4jh5A-1lkdA:
7.1
4jh5B-1lkdA:
6.2		 4jh5A-1lkdA:
17.85
4jh5B-1lkdA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH6_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 10 HIS A 210
TYR A 250
GLU A 260
HIS A 146
ALA A 198
 FE2  A 500 ( 3.5A)
P6G  A 600 ( 3.7A)
FE2  A 500 ( 2.8A)
FE2  A 500 ( 3.5A)
BP6  A 300 ( 4.2A)
 0.49A 4jh6A-1lkdA:
7.1
4jh6B-1lkdA:
6.6		 4jh6A-1lkdA:
17.85
4jh6B-1lkdA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH6_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 10 HIS A 146
ALA A 198
HIS A 210
TYR A 250
GLU A 260
 FE2  A 500 ( 3.5A)
BP6  A 300 ( 4.2A)
FE2  A 500 ( 3.5A)
P6G  A 600 ( 3.7A)
FE2  A 500 ( 2.8A)
 0.50A 4jh6A-1lkdA:
7.1
4jh6B-1lkdA:
6.6		 4jh6A-1lkdA:
17.85
4jh6B-1lkdA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH8_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 10 HIS A 210
TYR A 250
GLU A 260
HIS A 146
ALA A 198
 FE2  A 500 ( 3.5A)
P6G  A 600 ( 3.7A)
FE2  A 500 ( 2.8A)
FE2  A 500 ( 3.5A)
BP6  A 300 ( 4.2A)
 0.48A 4jh8A-1lkdA:
7.1
4jh8B-1lkdA:
6.6		 4jh8A-1lkdA:
17.85
4jh8B-1lkdA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH8_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 10 HIS A 146
ALA A 198
HIS A 210
TYR A 250
GLU A 260
 FE2  A 500 ( 3.5A)
BP6  A 300 ( 4.2A)
FE2  A 500 ( 3.5A)
P6G  A 600 ( 3.7A)
FE2  A 500 ( 2.8A)
 0.48A 4jh8A-1lkdA:
7.1
4jh8B-1lkdA:
6.6		 4jh8A-1lkdA:
17.85
4jh8B-1lkdA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		4 / 6 PHE A 147
MET A   9
ILE A 208
ARG A 149
 None
 1.37A 4mk4B-1lkdA:
undetectable		 4mk4B-1lkdA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 12 ASP A  39
VAL A  13
ALA A  12
GLY A  10
ASP A  15
 None
 1.09A 4mm8A-1lkdA:
undetectable		 4mm8A-1lkdA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		3 / 3 SER A 248
TYR A 250
ASP A 244
 None
P6G  A 600 ( 3.7A)
BP6  A 300 ( 4.4A)
 0.83A 4rp8C-1lkdA:
0.0		 4rp8C-1lkdA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		4 / 5 LEU A 197
MET A   9
LEU A  60
HIS A 210
 None
None
None
FE2  A 500 ( 3.5A)
 1.08A 4xi3B-1lkdA:
undetectable		 4xi3B-1lkdA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 11 ALA A 132
VAL A 259
GLY A 222
PHE A 249
GLY A 262
 None
 1.11A 4xp4A-1lkdA:
undetectable		 4xp4A-1lkdA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		4 / 4 GLY A 143
LEU A  29
PHE A  41
ILE A  50
 None
 0.90A 4xv2A-1lkdA:
0.0		 4xv2A-1lkdA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		3 / 3 LYS A   2
ILE A 116
ILE A 104
 None
 0.61A 4y0qA-1lkdA:
undetectable		 4y0qA-1lkdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 10 ALA A  83
ILE A  85
GLY A 166
LEU A 165
ASP A 108
 None
 1.24A 5ajqB-1lkdA:
undetectable		 5ajqB-1lkdA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		3 / 3 ASP A 244
ASN A 191
GLN A 142
 BP6  A 300 ( 4.4A)
None
None
 0.83A 5k7uA-1lkdA:
undetectable		 5k7uA-1lkdA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		4 / 8 SER A 287
SER A 236
MET A 175
SER A 281
 None
P6G  A 600 ( 4.0A)
P6G  A 600 (-4.4A)
BP6  A 300 ( 4.3A)
 1.12A 5l5fY-1lkdA:
0.0
5l5fZ-1lkdA:
undetectable		 5l5fY-1lkdA:
22.01
5l5fZ-1lkdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A 102
GLY A 119
ALA A 120
ILE A 104
LEU A  73
 None
 1.11A 6b3aA-1lkdA:
undetectable		 6b3aA-1lkdA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A 102
GLY A 119
ALA A 120
ILE A 104
LEU A  73
 None
 1.14A 6b3bA-1lkdA:
undetectable		 6b3bA-1lkdA:
19.53