SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lkf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 1lkf LEUKOCIDIN F SUBUNIT
(Staphylococcus
aureus) 		3 / 3 VAL A  84
VAL A 166
TRP A 164
 None
 0.90A 1av2C-1lkfA:
undetectable
1av2D-1lkfA:
undetectable		 1av2C-1lkfA:
4.28
1av2D-1lkfA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_A_ADNA1501_1
(CLASS B ACID
PHOSPHATASE)		 1lkf LEUKOCIDIN F SUBUNIT
(Staphylococcus
aureus) 		5 / 10 ASP A  26
TYR A 278
LEU A  36
GLY A  57
THR A 292
 None
 1.34A 1rmtA-1lkfA:
undetectable		 1rmtA-1lkfA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 1lkf LEUKOCIDIN F SUBUNIT
(Staphylococcus
aureus) 		3 / 3 VAL A  84
VAL A 166
TRP A 164
 None
 0.96A 1w5uC-1lkfA:
undetectable
1w5uD-1lkfA:
undetectable		 1w5uC-1lkfA:
4.28
1w5uD-1lkfA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1lkf LEUKOCIDIN F SUBUNIT
(Staphylococcus
aureus) 		5 / 12 PHE A 225
TYR A  99
SER A 227
ALA A  23
TYR A 278
 None
 1.12A 2avdA-1lkfA:
undetectable		 2avdA-1lkfA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 1lkf LEUKOCIDIN F SUBUNIT
(Staphylococcus
aureus) 		5 / 10 ASP A  26
TYR A 278
LEU A  36
GLY A  57
THR A 292
 None
 1.39A 2b8jB-1lkfA:
undetectable		 2b8jB-1lkfA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 1lkf LEUKOCIDIN F SUBUNIT
(Staphylococcus
aureus) 		3 / 3 VAL A 166
TRP A 164
VAL A  84
 None
 0.87A 2izqA-1lkfA:
undetectable
2izqB-1lkfA:
undetectable		 2izqA-1lkfA:
4.28
2izqB-1lkfA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1lkf LEUKOCIDIN F SUBUNIT
(Staphylococcus
aureus) 		3 / 3 LEU A  76
TYR A 252
GLN A 253
 None
 0.75A 2wekA-1lkfA:
undetectable		 2wekA-1lkfA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1lkf LEUKOCIDIN F SUBUNIT
(Staphylococcus
aureus) 		5 / 12 LEU A  51
SER A 227
ARG A 232
VAL A  97
SER A  88
 None
 1.44A 2xpwA-1lkfA:
undetectable		 2xpwA-1lkfA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1lkf LEUKOCIDIN F SUBUNIT
(Staphylococcus
aureus) 		4 / 7 THR A 244
VAL A  84
ILE A  59
ILE A  32
 None
 0.87A 3deuA-1lkfA:
undetectable		 3deuA-1lkfA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 1lkf LEUKOCIDIN F SUBUNIT
(Staphylococcus
aureus) 		3 / 3 VAL A  84
VAL A 166
TRP A 164
 None
 0.70A 3l8lA-1lkfA:
undetectable
3l8lB-1lkfA:
undetectable		 3l8lA-1lkfA:
4.28
3l8lB-1lkfA:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1lkf LEUKOCIDIN F SUBUNIT
(Staphylococcus
aureus) 		4 / 5 LEU A 290
GLN A  89
THR A 277
GLU A 279
 None
 1.37A 3n58C-1lkfA:
undetectable		 3n58C-1lkfA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 1lkf LEUKOCIDIN F SUBUNIT
(Staphylococcus
aureus) 		4 / 5 THR A   5
ILE A   4
LYS A   3
PHE A  38
 None
 1.24A 4ac9C-1lkfA:
undetectable		 4ac9C-1lkfA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1lkf LEUKOCIDIN F SUBUNIT
(Staphylococcus
aureus) 		5 / 11 ILE A 208
ALA A 195
GLY A 196
GLY A 189
ASN A 173
 None
 1.30A 4jdsA-1lkfA:
undetectable		 4jdsA-1lkfA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1lkf LEUKOCIDIN F SUBUNIT
(Staphylococcus
aureus) 		5 / 11 ILE A 208
ALA A 195
GLY A 196
GLY A 189
ASN A 173
 None
 1.32A 4jdsB-1lkfA:
undetectable		 4jdsB-1lkfA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1lkf LEUKOCIDIN F SUBUNIT
(Staphylococcus
aureus) 		5 / 11 ILE A 208
ALA A 195
GLY A 196
GLY A 189
ASN A 173
 None
 1.32A 4jdsC-1lkfA:
undetectable		 4jdsC-1lkfA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 1lkf LEUKOCIDIN F SUBUNIT
(Staphylococcus
aureus) 		5 / 12 TYR A 149
ILE A 171
TYR A  82
LEU A 192
LEU A  76
 None
 1.21A 5zwrA-1lkfA:
undetectable		 5zwrA-1lkfA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 1lkf LEUKOCIDIN F SUBUNIT
(Staphylococcus
aureus) 		5 / 12 LEU A  36
GLY A   2
TYR A 245
ASN A 222
PRO A 223
 None
 1.06A 6ce2B-1lkfA:
undetectable		 6ce2B-1lkfA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 1lkf LEUKOCIDIN F SUBUNIT
(Staphylococcus
aureus) 		3 / 3 TYR A 245
ALA A  25
LEU A  36
 None
 0.75A 6d9kF-1lkfA:
undetectable		 6d9kF-1lkfA:
16.33