SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lki'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1lki LEUKEMIA INHIBITORY
FACTOR
(Mus
musculus) 		5 / 12 LEU A  83
GLU A  76
LEU A 130
LEU A 133
PHE A 180
 None
 1.48A 1d4fD-1lkiA:
undetectable		 1d4fD-1lkiA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1lki LEUKEMIA INHIBITORY
FACTOR
(Mus
musculus) 		5 / 9 LEU A  94
ILE A 173
ALA A  37
SER A  36
LEU A  40
 None
 1.10A 1eqgA-1lkiA:
undetectable		 1eqgA-1lkiA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1lki LEUKEMIA INHIBITORY
FACTOR
(Mus
musculus) 		5 / 11 LEU A  94
ILE A 173
ALA A  37
SER A  36
LEU A  40
 None
 1.08A 1eqgB-1lkiA:
undetectable		 1eqgB-1lkiA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 1lki LEUKEMIA INHIBITORY
FACTOR
(Mus
musculus) 		4 / 4 LEU A  40
SER A  43
TYR A  44
LEU A 166
 None
 0.87A 1xz1A-1lkiA:
5.8		 1xz1A-1lkiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 1lki LEUKEMIA INHIBITORY
FACTOR
(Mus
musculus) 		4 / 4 LEU A  40
SER A  43
TYR A  44
LEU A 166
 None
 0.86A 1xz3A-1lkiA:
5.1		 1xz3A-1lkiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 1lki LEUKEMIA INHIBITORY
FACTOR
(Mus
musculus) 		4 / 6 LEU A  40
SER A  43
TYR A  44
LEU A 166
 None
 0.86A 3f33A-1lkiA:
5.0		 3f33A-1lkiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1lki LEUKEMIA INHIBITORY
FACTOR
(Mus
musculus) 		4 / 7 PHE A  70
VAL A  87
LEU A  90
SER A  91
 None
 0.61A 3hs6B-1lkiA:
undetectable		 3hs6B-1lkiA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1lki LEUKEMIA INHIBITORY
FACTOR
(Mus
musculus) 		5 / 12 LEU A  94
ILE A 173
ALA A  37
SER A  36
LEU A  40
 None
 1.05A 3n8xB-1lkiA:
undetectable		 3n8xB-1lkiA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 1lki LEUKEMIA INHIBITORY
FACTOR
(Mus
musculus) 		4 / 6 LEU A  40
SER A  43
TYR A  44
LEU A 166
 None
 0.85A 3ravA-1lkiA:
4.9		 3ravA-1lkiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 1lki LEUKEMIA INHIBITORY
FACTOR
(Mus
musculus) 		4 / 5 LEU A  80
LEU A  83
LEU A 126
SER A 127
 None
 0.67A 3vhuA-1lkiA:
0.3		 3vhuA-1lkiA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1lki LEUKEMIA INHIBITORY
FACTOR
(Mus
musculus) 		5 / 12 GLY A  20
LEU A  80
PHE A  70
PHE A 180
LEU A 125
 None
 1.26A 4ze1A-1lkiA:
undetectable		 4ze1A-1lkiA:
16.29