SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1llc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 1llc L-LACTATE
DEHYDROGENASE
(Lactobacillus
casei) 		5 / 9 VAL A  27
GLY A  28
ASP A  53
ILE A  54
ILE A 119
 None
 0.94A 1cetA-1llcA:
37.7		 1cetA-1llcA:
33.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 1llc L-LACTATE
DEHYDROGENASE
(Lactobacillus
casei) 		3 / 3 ALA A 215
VAL A 213
TRP A 212
 None
 0.95A 1gmkA-1llcA:
undetectable
1gmkB-1llcA:
undetectable		 1gmkA-1llcA:
4.84
1gmkB-1llcA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1llc L-LACTATE
DEHYDROGENASE
(Lactobacillus
casei) 		5 / 12 ASN A 296
ARG A 159
ASP A  92
ALA A  91
ALA A  88
 None
 1.13A 2br4B-1llcA:
2.7		 2br4B-1llcA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 1llc L-LACTATE
DEHYDROGENASE
(Lactobacillus
casei) 		5 / 9 GLY A  30
THR A 149
VAL A  27
ILE A 123
VAL A 124
 None
 1.29A 2nnhB-1llcA:
undetectable		 2nnhB-1llcA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1llc L-LACTATE
DEHYDROGENASE
(Lactobacillus
casei) 		4 / 8 MET A 275
GLN A 278
LEU A 271
GLY A 162
 None
 0.84A 2qqcH-1llcA:
undetectable
2qqcK-1llcA:
undetectable		 2qqcH-1llcA:
17.65
2qqcK-1llcA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1llc L-LACTATE
DEHYDROGENASE
(Lactobacillus
casei) 		5 / 8 HIS A 195
LEU A 136
ILE A 257
LEU A 254
THR A  97
 SO4  A   2 ( 3.5A)
None
None
None
None
 1.20A 2xfhA-1llcA:
undetectable		 2xfhA-1llcA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 1llc L-LACTATE
DEHYDROGENASE
(Lactobacillus
casei) 		4 / 6 LEU A  70
LEU A  42
VAL A  41
PHE A  72
 None
 1.26A 4uswA-1llcA:
0.0		 4uswA-1llcA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1llc L-LACTATE
DEHYDROGENASE
(Lactobacillus
casei) 		4 / 7 ILE A 281
PHE A 200
GLY A 193
THR A 165
 None
 0.92A 4ze3A-1llcA:
undetectable		 4ze3A-1llcA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 1llc L-LACTATE
DEHYDROGENASE
(Lactobacillus
casei) 		3 / 3 ASP A 234
ARG A 233
TYR A 237
 None
 0.82A 5a7mA-1llcA:
undetectable		 5a7mA-1llcA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 1llc L-LACTATE
DEHYDROGENASE
(Lactobacillus
casei) 		3 / 3 ASP A 234
ARG A 233
TYR A 237
 None
 0.81A 5a7mB-1llcA:
undetectable		 5a7mB-1llcA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1llc L-LACTATE
DEHYDROGENASE
(Lactobacillus
casei) 		5 / 8 LEU A 307
ILE A 281
PHE A 200
GLY A 193
THR A 165
 None
 1.00A 5eseA-1llcA:
undetectable		 5eseA-1llcA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1llc L-LACTATE
DEHYDROGENASE
(Lactobacillus
casei) 		4 / 8 LEU A 322
ILE A 281
GLY A 288
THR A 165
 None
 0.73A 5eseA-1llcA:
undetectable		 5eseA-1llcA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1llc L-LACTATE
DEHYDROGENASE
(Lactobacillus
casei) 		5 / 12 LEU A 307
ILE A 281
PHE A 200
GLY A 193
THR A 165
 None
 0.99A 5eskA-1llcA:
undetectable		 5eskA-1llcA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1llc L-LACTATE
DEHYDROGENASE
(Lactobacillus
casei) 		4 / 7 ILE A 281
PHE A 200
GLY A 193
THR A 165
 None
 0.99A 5esmA-1llcA:
1.8		 5esmA-1llcA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1llc L-LACTATE
DEHYDROGENASE
(Lactobacillus
casei) 		4 / 7 LEU A 285
ILE A 191
THR A 165
MET A 315
 None
 1.47A 5ljcA-1llcA:
0.0		 5ljcA-1llcA:
21.52