SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lm5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 1lm5 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		5 / 12 ALA A2805
ILE A2631
GLY A2640
ILE A2633
ILE A2622
 None
 0.80A 1hshA-1lm5A:
undetectable		 1hshA-1lm5A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 1lm5 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		5 / 9 ALA A2805
ILE A2631
GLY A2640
ILE A2633
ILE A2622
 None
 0.88A 1hshB-1lm5A:
undetectable		 1hshB-1lm5A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 1lm5 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		5 / 12 LEU A2764
LEU A2736
THR A2657
ALA A2709
ALA A2694
 None
 1.12A 1n5xA-1lm5A:
undetectable		 1n5xA-1lm5A:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 1lm5 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		5 / 12 LEU A2764
LEU A2736
THR A2657
ALA A2709
ALA A2694
 None
 1.12A 1n5xB-1lm5A:
undetectable		 1n5xB-1lm5A:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 1lm5 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		5 / 10 ARG A2639
ILE A2641
ILE A2619
TYR A2785
ILE A2789
 None
 1.36A 3ohtA-1lm5A:
undetectable
3ohtB-1lm5A:
undetectable		 3ohtA-1lm5A:
19.08
3ohtB-1lm5A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 1lm5 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		5 / 9 LEU A2800
LEU A2650
SER A2792
LEU A2802
ILE A2622
 None
 1.08A 4ubsA-1lm5A:
undetectable		 4ubsA-1lm5A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1lm5 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		3 / 3 THR A2733
HIS A2662
LEU A2800
 None
 0.77A 5axdA-1lm5A:
undetectable		 5axdA-1lm5A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1lm5 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		3 / 3 THR A2733
HIS A2662
LEU A2800
 None
 0.81A 5axdC-1lm5A:
undetectable		 5axdC-1lm5A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 1lm5 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		4 / 7 GLN A2730
GLY A2735
ILE A2756
GLN A2762
 None
 0.90A 5vlmC-1lm5A:
undetectable		 5vlmC-1lm5A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 1lm5 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		4 / 8 GLN A2730
GLY A2735
ILE A2756
GLN A2762
 None
 0.91A 5vlmD-1lm5A:
0.0		 5vlmD-1lm5A:
22.67