SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lm7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1lm7 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		3 / 3 SER A2402
GLU A2403
GLU A2399
 None
 0.69A 1eqbD-1lm7A:
undetectable		 1eqbD-1lm7A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1lm7 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		3 / 3 SER A2402
GLU A2403
GLU A2399
 None
 0.70A 1eqbB-1lm7A:
undetectable		 1eqbB-1lm7A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1lm7 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		4 / 8 GLY A2364
ALA A2353
ILE A2359
SER A2349
 None
 0.82A 1utdI-1lm7A:
undetectable
1utdJ-1lm7A:
undetectable		 1utdI-1lm7A:
16.53
1utdJ-1lm7A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1lm7 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		5 / 8 GLU A2333
GLY A2299
THR A2298
ALA A2297
ALA A2296
 None
 1.31A 2ej3C-1lm7A:
undetectable		 2ej3C-1lm7A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 1lm7 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		3 / 3 TYR A2392
GLY A2395
PHE A2397
 None
 0.69A 2m2pB-1lm7A:
undetectable		 2m2pB-1lm7A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 1lm7 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		5 / 11 THR A2287
ILE A2263
LEU A2429
ASN A2423
ILE A2260
 None
 1.37A 3a50B-1lm7A:
undetectable		 3a50B-1lm7A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1lm7 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		4 / 6 TYR A2316
GLU A2324
TYR A2275
LEU A2292
 None
 1.32A 4twdB-1lm7A:
undetectable
4twdC-1lm7A:
undetectable		 4twdB-1lm7A:
22.09
4twdC-1lm7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1lm7 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		4 / 6 TYR A2316
GLU A2324
TYR A2275
LEU A2292
 None
 1.30A 4twdD-1lm7A:
undetectable
4twdE-1lm7A:
undetectable		 4twdD-1lm7A:
22.09
4twdE-1lm7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1lm7 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		4 / 7 GLU A2324
TYR A2275
LEU A2292
TYR A2316
 None
 1.19A 4twdF-1lm7A:
undetectable
4twdJ-1lm7A:
undetectable		 4twdF-1lm7A:
22.09
4twdJ-1lm7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1lm7 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		4 / 6 TYR A2316
GLU A2324
TYR A2275
LEU A2292
 None
 1.12A 4twdF-1lm7A:
0.0
4twdG-1lm7A:
undetectable		 4twdF-1lm7A:
22.09
4twdG-1lm7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1lm7 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		4 / 8 PRO A2418
ILE A2263
PRO A2304
LEU A2443
 None
 0.94A 5g48A-1lm7A:
undetectable		 5g48A-1lm7A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1lm7 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens) 		4 / 7 GLY A2319
GLY A2322
PHE A2325
LEU A2292
 None
 0.87A 5izfA-1lm7A:
undetectable		 5izfA-1lm7A:
22.07