SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lme'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 1lme PEPTIDE DEFORMYLASE
(Thermotoga
maritima) 		5 / 12 MET A  33
LEU A  45
GLY A  44
VAL A 126
LEU A 134
 None
 1.41A 1nhzA-1lmeA:
undetectable		 1nhzA-1lmeA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 1lme PEPTIDE DEFORMYLASE
(Thermotoga
maritima) 		5 / 12 PHE A  90
ILE A  97
GLY A  86
HIS A 129
HIS A 133
 OCS  A  87 ( 4.4A)
None
OCS  A  87 ( 2.4A)
OCS  A  87 ( 3.9A)
OCS  A  87 ( 4.0A)
 1.20A 2pgfA-1lmeA:
undetectable		 2pgfA-1lmeA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 1lme PEPTIDE DEFORMYLASE
(Thermotoga
maritima) 		5 / 12 PHE A  90
ILE A  97
GLY A  86
HIS A 129
HIS A 133
 OCS  A  87 ( 4.4A)
None
OCS  A  87 ( 2.4A)
OCS  A  87 ( 3.9A)
OCS  A  87 ( 4.0A)
 1.17A 2pgrA-1lmeA:
undetectable		 2pgrA-1lmeA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA301_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1lme PEPTIDE DEFORMYLASE
(Thermotoga
maritima) 		4 / 6 ARG A 142
ILE A 139
VAL A 137
HIS A 133
 None
OCS  A  87 ( 4.6A)
None
OCS  A  87 ( 4.0A)
 1.04A 3deuA-1lmeA:
undetectable		 3deuA-1lmeA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB302_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1lme PEPTIDE DEFORMYLASE
(Thermotoga
maritima) 		4 / 5 ARG A 142
ILE A 139
VAL A 137
HIS A 133
 None
OCS  A  87 ( 4.6A)
None
OCS  A  87 ( 4.0A)
 1.11A 3deuB-1lmeA:
0.0		 3deuB-1lmeA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 1lme PEPTIDE DEFORMYLASE
(Thermotoga
maritima) 		5 / 12 MET A  33
LEU A  45
GLY A  44
VAL A 126
LEU A 134
 None
 1.37A 3h52A-1lmeA:
undetectable		 3h52A-1lmeA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 1lme PEPTIDE DEFORMYLASE
(Thermotoga
maritima) 		4 / 5 THR A 110
ILE A  30
LYS A  27
GLU A  31
 None
 1.35A 4ac9C-1lmeA:
undetectable		 4ac9C-1lmeA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1lme PEPTIDE DEFORMYLASE
(Thermotoga
maritima) 		4 / 5 THR A 110
ILE A  30
LYS A  27
GLU A  31
 None
 1.37A 4acaC-1lmeA:
undetectable		 4acaC-1lmeA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 1lme PEPTIDE DEFORMYLASE
(Thermotoga
maritima) 		4 / 5 ILE A  34
PRO A  65
TYR A 122
VAL A 126
 None
 1.24A 4s0vA-1lmeA:
undetectable		 4s0vA-1lmeA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1lme PEPTIDE DEFORMYLASE
(Thermotoga
maritima) 		4 / 4 LEU A 138
ARG A  99
ILE A 139
ILE A  97
 OCS  A  87 ( 4.8A)
None
OCS  A  87 ( 4.6A)
None
 1.33A 5dzk2-1lmeA:
undetectable
5dzkM-1lmeA:
undetectable
5dzkN-1lmeA:
undetectable		 5dzk2-1lmeA:
1.23
5dzkM-1lmeA:
21.60
5dzkN-1lmeA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1lme PEPTIDE DEFORMYLASE
(Thermotoga
maritima) 		4 / 4 ILE A 139
ILE A  97
ARG A  99
LEU A 138
 OCS  A  87 ( 4.6A)
None
None
OCS  A  87 ( 4.8A)
 1.34A 5dzkh-1lmeA:
undetectable
5dzkn-1lmeA:
0.0
5dzkv-1lmeA:
undetectable		 5dzkh-1lmeA:
21.60
5dzkn-1lmeA:
21.60
5dzkv-1lmeA:
1.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 1lme PEPTIDE DEFORMYLASE
(Thermotoga
maritima) 		5 / 11 ARG A 125
VAL A 137
ILE A  73
ILE A 103
ILE A  76
 None
 1.35A 5hw8B-1lmeA:
undetectable		 5hw8B-1lmeA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1lme PEPTIDE DEFORMYLASE
(Thermotoga
maritima) 		3 / 3 GLU A 130
HIS A 129
ARG A 125
 None
OCS  A  87 ( 3.9A)
None
 0.97A 5uunA-1lmeA:
0.0		 5uunA-1lmeA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1lme PEPTIDE DEFORMYLASE
(Thermotoga
maritima) 		3 / 3 HIS A 133
HIS A 129
ARG A  99
 OCS  A  87 ( 4.0A)
OCS  A  87 ( 3.9A)
None
 1.13A 6b58A-1lmeA:
undetectable		 6b58A-1lmeA:
15.57