SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lmk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1lmk ANTI-PHOSPHATIDYLINO
SITOL SPECIFIC
PHOSPHOLIPASE C
DIABODY
(Mus
musculus) 		4 / 8 HIS A 239
TYR A 241
TYR A 254
SER A 296
 None
 0.66A 1i7zA-1lmkA:
15.6		 1i7zA-1lmkA:
53.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 1lmk ANTI-PHOSPHATIDYLINO
SITOL SPECIFIC
PHOSPHOLIPASE C
DIABODY
(Mus
musculus) 		5 / 12 ASP A  90
PHE A  64
MET A  81
PHE A  70
GLY A  66
 None
 1.26A 2fqyA-1lmkA:
undetectable		 2fqyA-1lmkA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 1lmk ANTI-PHOSPHATIDYLINO
SITOL SPECIFIC
PHOSPHOLIPASE C
DIABODY
(Mus
musculus) 		4 / 4 LEU A 288
GLY A 289
LEU A 309
GLU A 310
 None
 1.12A 3tgvB-1lmkA:
undetectable		 3tgvB-1lmkA:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 1lmk ANTI-PHOSPHATIDYLINO
SITOL SPECIFIC
PHOSPHOLIPASE C
DIABODY
(Mus
musculus) 		4 / 5 VAL A   2
TYR A  27
ARG A  98
TYR A 111
 None
 0.40A 4m7kH-1lmkA:
22.6		 4m7kH-1lmkA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 1lmk ANTI-PHOSPHATIDYLINO
SITOL SPECIFIC
PHOSPHOLIPASE C
DIABODY
(Mus
musculus) 		5 / 12 VAL A 213
VAL A 263
GLN A 247
ILE A 253
PHE A 267
 None
 1.32A 6becA-1lmkA:
2.0
6becB-1lmkA:
2.5
6becC-1lmkA:
1.9		 6becA-1lmkA:
16.72
6becB-1lmkA:
16.72
6becC-1lmkA:
16.72