SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lns'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 12 LEU A 521
LEU A 522
VAL A 518
VAL A 204
LEU A 273
 None
 1.12A 1db1A-1lnsA:
0.0		 1db1A-1lnsA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		3 / 3 PHE A  40
LEU A  51
SER A  46
 None
 0.95A 1e7aA-1lnsA:
2.1		 1e7aA-1lnsA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 8 ASP A 468
HIS A 498
HIS A 464
ILE A 374
 None
 0.95A 1ei6C-1lnsA:
undetectable		 1ei6C-1lnsA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 7 GLY A 395
ASP A 732
SER A 389
HIS A 735
 None
 0.91A 1gxsA-1lnsA:
6.1
1gxsB-1lnsA:
0.0		 1gxsA-1lnsA:
16.98
1gxsB-1lnsA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 4 HIS A 464
ALA A 476
PHE A 479
GLY A 373
 None
 1.33A 1mj2B-1lnsA:
undetectable		 1mj2B-1lnsA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 4 HIS A 464
ALA A 476
PHE A 479
GLY A 373
 None
 1.31A 1mj2D-1lnsA:
undetectable		 1mj2D-1lnsA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 4 HIS A 464
ALA A 476
PHE A 479
GLY A 373
 None
 1.32A 1mjoB-1lnsA:
undetectable		 1mjoB-1lnsA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 4 HIS A 464
ALA A 476
PHE A 479
GLY A 373
 None
 1.31A 1mjoA-1lnsA:
undetectable		 1mjoA-1lnsA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 4 HIS A 464
ALA A 476
PHE A 479
GLY A 373
 None
 1.32A 1mjoD-1lnsA:
undetectable		 1mjoD-1lnsA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 11 ILE A 507
LEU A 369
LEU A 530
ASN A 274
VAL A 204
 None
 1.38A 1mrlA-1lnsA:
0.3
1mrlB-1lnsA:
0.1		 1mrlA-1lnsA:
14.42
1mrlB-1lnsA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 12 ILE A 507
LEU A 369
LEU A 530
ASN A 274
VAL A 204
 None
 1.46A 1mrlB-1lnsA:
0.4
1mrlC-1lnsA:
0.7		 1mrlB-1lnsA:
14.42
1mrlC-1lnsA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 12 TYR A 210
THR A 352
ALA A 288
SER A 208
TYR A 381
 None
 1.09A 1nbiC-1lnsA:
undetectable		 1nbiC-1lnsA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 12 TYR A 210
THR A 352
ALA A 288
SER A 208
TYR A 381
 None
 1.08A 1nbiD-1lnsA:
undetectable		 1nbiD-1lnsA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 7 THR A 736
PHE A 685
PHE A 586
LEU A 593
 None
 1.02A 1qcaA-1lnsA:
0.0		 1qcaA-1lnsA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 6 LEU A 404
GLU A 396
THR A 352
TYR A 349
 None
 1.17A 1qvuA-1lnsA:
0.0		 1qvuA-1lnsA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		3 / 3 LYS A 481
ILE A 462
THR A 359
 None
 0.85A 1rx3A-1lnsA:
undetectable		 1rx3A-1lnsA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 12 TYR A 210
TYR A 380
ASN A 470
VAL A 471
HIS A 498
 None
 0.53A 1x70A-1lnsA:
7.8		 1x70A-1lnsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		6 / 12 GLU A 396
SER A 348
TYR A 380
ASN A 470
VAL A 471
HIS A 498
 None
 0.51A 1x70B-1lnsA:
7.6		 1x70B-1lnsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		3 / 3 LYS A 233
ASP A 446
ASP A 439
 None
 0.77A 2br4D-1lnsA:
undetectable		 2br4D-1lnsA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 6 TYR A 349
GLY A 302
TYR A 381
ASP A 303
 None
 1.23A 2g72A-1lnsA:
undetectable		 2g72A-1lnsA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		6 / 12 GLY A 346
VAL A 460
ILE A 462
GLY A 373
ILE A 374
ILE A 368
 None
 1.36A 2o4kB-1lnsA:
undetectable		 2o4kB-1lnsA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		3 / 3 LEU A 244
TYR A 304
GLY A 302
 None
 0.60A 2ocuA-1lnsA:
undetectable		 2ocuA-1lnsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 12 ILE A 368
ALA A 476
GLY A 373
VAL A 471
PHE A 550
 None
 1.19A 2okcB-1lnsA:
undetectable		 2okcB-1lnsA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 8 LEU A 398
PRO A 209
VAL A 290
GLY A 291
 None
 0.85A 2po5A-1lnsA:
1.8		 2po5A-1lnsA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 8 LEU A 398
PRO A 209
VAL A 290
GLY A 291
 None
 0.82A 2po5B-1lnsA:
undetectable		 2po5B-1lnsA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		3 / 3 ARG A 382
SER A 437
TYR A 378
 None
 0.75A 2q2hA-1lnsA:
0.0
2q2hB-1lnsA:
0.0		 2q2hA-1lnsA:
11.16
2q2hB-1lnsA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 11 LEU A 637
LEU A 680
ILE A 727
THR A 472
HIS A 735
 None
 1.11A 2qd3A-1lnsA:
2.3		 2qd3A-1lnsA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 8 LEU A 398
PRO A 209
VAL A 290
GLY A 291
 None
 0.98A 2qd5A-1lnsA:
1.8		 2qd5A-1lnsA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 8 LEU A 398
PRO A 209
VAL A 290
GLY A 291
 None
 0.86A 2qd5B-1lnsA:
2.0		 2qd5B-1lnsA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		6 / 12 GLU A 396
SER A 348
TYR A 349
TYR A 380
VAL A 471
HIS A 498
 None
 0.79A 2rguA-1lnsA:
19.9		 2rguA-1lnsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 12 TYR A 210
SER A 348
TYR A 349
TYR A 380
HIS A 498
 None
 0.81A 2rguA-1lnsA:
19.9		 2rguA-1lnsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_B_356B902_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		6 / 11 GLU A 396
SER A 348
TYR A 349
TYR A 380
VAL A 471
HIS A 498
 None
 0.81A 2rguB-1lnsA:
10.5		 2rguB-1lnsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 8 TYR A 381
ARG A 435
TRP A 444
ARG A 447
 None
 1.38A 2vxaA-1lnsA:
0.0
2vxaC-1lnsA:
0.0
2vxaE-1lnsA:
0.0		 2vxaA-1lnsA:
6.19
2vxaC-1lnsA:
6.19
2vxaE-1lnsA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 8 ARG A 447
TYR A 381
ARG A 435
TRP A 444
 None
 1.38A 2vxaA-1lnsA:
0.0
2vxaB-1lnsA:
0.0
2vxaK-1lnsA:
0.0		 2vxaA-1lnsA:
6.19
2vxaB-1lnsA:
6.19
2vxaK-1lnsA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 8 ARG A 447
TYR A 381
ARG A 435
TRP A 444
 None
 1.37A 2vxaB-1lnsA:
0.0
2vxaC-1lnsA:
0.0
2vxaG-1lnsA:
0.0		 2vxaB-1lnsA:
6.19
2vxaC-1lnsA:
6.19
2vxaG-1lnsA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 8 TYR A 381
ARG A 435
TRP A 444
ARG A 447
 None
 1.39A 2vxaD-1lnsA:
0.0
2vxaF-1lnsA:
0.0
2vxaI-1lnsA:
0.0		 2vxaD-1lnsA:
6.19
2vxaF-1lnsA:
6.19
2vxaI-1lnsA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 8 ARG A 447
TYR A 381
ARG A 435
TRP A 444
 None
 1.37A 2vxaD-1lnsA:
0.0
2vxaE-1lnsA:
0.0
2vxaL-1lnsA:
0.0		 2vxaD-1lnsA:
6.19
2vxaE-1lnsA:
6.19
2vxaL-1lnsA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 8 ARG A 447
TYR A 381
ARG A 435
TRP A 444
 None
 1.39A 2vxaB-1lnsA:
0.0
2vxaG-1lnsA:
0.0
2vxaH-1lnsA:
0.0		 2vxaB-1lnsA:
6.19
2vxaG-1lnsA:
6.19
2vxaH-1lnsA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 8 ARG A 447
TYR A 381
ARG A 435
TRP A 444
 None
 1.35A 2vxaH-1lnsA:
0.0
2vxaI-1lnsA:
0.0
2vxaJ-1lnsA:
0.0		 2vxaH-1lnsA:
6.19
2vxaI-1lnsA:
6.19
2vxaJ-1lnsA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 8 TYR A 381
ARG A 435
TRP A 444
ARG A 447
 None
 1.35A 2vxaD-1lnsA:
0.0
2vxaJ-1lnsA:
0.0
2vxaL-1lnsA:
0.0		 2vxaD-1lnsA:
6.19
2vxaJ-1lnsA:
6.19
2vxaL-1lnsA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 8 ARG A 447
TYR A 381
ARG A 435
TRP A 444
 None
 1.35A 2vxaH-1lnsA:
0.0
2vxaJ-1lnsA:
0.0
2vxaK-1lnsA:
0.0		 2vxaH-1lnsA:
6.19
2vxaJ-1lnsA:
6.19
2vxaK-1lnsA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 8 ARG A 447
TYR A 381
ARG A 435
TRP A 444
 None
 1.35A 2vxaA-1lnsA:
0.0
2vxaK-1lnsA:
0.0
2vxaL-1lnsA:
0.0		 2vxaA-1lnsA:
6.19
2vxaK-1lnsA:
6.19
2vxaL-1lnsA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 8 PHE A  25
LEU A 134
VAL A 135
LEU A 124
 None
 0.78A 2w98B-1lnsA:
undetectable		 2w98B-1lnsA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		3 / 3 ASP A 178
THR A 325
GLU A 174
 None
 0.74A 2zifB-1lnsA:
1.9		 2zifB-1lnsA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		3 / 3 ASP A 259
THR A 266
GLU A 167
 None
 0.76A 2zifB-1lnsA:
1.9		 2zifB-1lnsA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 12 LEU A 522
VAL A 518
VAL A 204
LEU A 273
LEU A 461
 None
 1.29A 2zlcA-1lnsA:
0.0		 2zlcA-1lnsA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 12 TRP A 444
HIS A 498
SER A 376
TYR A 380
ILE A 374
 None
 1.44A 3b7pC-1lnsA:
undetectable		 3b7pC-1lnsA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		7 / 12 GLU A 396
SER A 348
TYR A 349
TYR A 380
ASN A 470
VAL A 471
HIS A 498
 None
 0.80A 3bjmA-1lnsA:
19.8		 3bjmA-1lnsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		7 / 12 TYR A 210
SER A 348
TYR A 349
TYR A 380
ASN A 470
VAL A 471
HIS A 498
 None
 0.64A 3bjmA-1lnsA:
19.8		 3bjmA-1lnsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		6 / 12 GLU A 396
SER A 348
TYR A 380
ASN A 470
VAL A 471
HIS A 498
 None
 0.59A 3bjmB-1lnsA:
7.2		 3bjmB-1lnsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		6 / 12 TYR A 210
SER A 348
TYR A 380
ASN A 470
VAL A 471
HIS A 498
 None
 0.64A 3bjmB-1lnsA:
7.2		 3bjmB-1lnsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 12 LEU A  23
ASN A 154
LEU A 158
THR A 160
LEU A 124
 None
 1.38A 3fsuA-1lnsA:
undetectable		 3fsuA-1lnsA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 10 GLY A 297
GLY A 291
THR A 292
TYR A 406
ILE A 188
 None
 1.22A 3fw1A-1lnsA:
2.1		 3fw1A-1lnsA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		7 / 12 GLU A 396
SER A 348
TYR A 349
TYR A 380
ASN A 470
VAL A 471
HIS A 498
 None
 0.92A 3g0bA-1lnsA:
8.4		 3g0bA-1lnsA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		7 / 12 GLU A 396
SER A 348
TYR A 349
TYR A 380
ASN A 470
VAL A 471
HIS A 498
 None
 0.90A 3g0bB-1lnsA:
7.6		 3g0bB-1lnsA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		7 / 12 GLU A 396
SER A 348
TYR A 349
TYR A 380
ASN A 470
VAL A 471
HIS A 498
 None
 0.92A 3g0bC-1lnsA:
19.7		 3g0bC-1lnsA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		7 / 12 GLU A 396
SER A 348
TYR A 349
TYR A 380
ASN A 470
VAL A 471
HIS A 498
 None
 0.91A 3g0bD-1lnsA:
20.3		 3g0bD-1lnsA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 12 LEU A 521
LEU A 522
VAL A 518
VAL A 204
LEU A 273
 None
 1.22A 3m7rA-1lnsA:
0.0		 3m7rA-1lnsA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		3 / 3 TYR A 380
ASP A 468
ASP A 647
 None
 0.94A 3ou6B-1lnsA:
undetectable		 3ou6B-1lnsA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		3 / 3 TYR A 477
GLY A 551
ASP A 549
 None
 0.73A 3ou6C-1lnsA:
undetectable		 3ou6C-1lnsA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 11 ALA A 283
ASN A 318
ILE A 314
GLY A 340
ALA A 338
 None
 1.08A 3rukD-1lnsA:
undetectable		 3rukD-1lnsA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		7 / 12 GLU A 396
SER A 348
TYR A 349
TYR A 380
ASN A 470
VAL A 471
HIS A 498
 None
 0.69A 3w2tA-1lnsA:
15.4		 3w2tA-1lnsA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		7 / 12 TYR A 210
SER A 348
TYR A 349
TYR A 380
ASN A 470
VAL A 471
HIS A 498
 None
 0.65A 3w2tA-1lnsA:
15.4		 3w2tA-1lnsA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		7 / 12 GLU A 396
SER A 348
TYR A 349
TYR A 380
ASN A 470
VAL A 471
HIS A 498
 None
 0.69A 3w2tB-1lnsA:
7.6		 3w2tB-1lnsA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		7 / 12 TYR A 210
SER A 348
TYR A 349
TYR A 380
ASN A 470
VAL A 471
HIS A 498
 None
 0.63A 3w2tB-1lnsA:
7.6		 3w2tB-1lnsA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 5 VAL A 533
LEU A 493
LEU A 535
ASN A 614
 None
 0.83A 4a9jA-1lnsA:
0.0		 4a9jA-1lnsA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 5 VAL A 533
LEU A 493
LEU A 535
ASN A 614
 None
 0.82A 4a9jB-1lnsA:
0.0		 4a9jB-1lnsA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 5 VAL A 533
LEU A 493
LEU A 535
ASN A 614
 None
 0.85A 4a9jC-1lnsA:
0.0		 4a9jC-1lnsA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 12 LEU A 637
LEU A 680
ILE A 727
THR A 472
HIS A 735
 None
 1.12A 4f4dB-1lnsA:
1.9		 4f4dB-1lnsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		6 / 12 GLU A 396
SER A 348
TYR A 380
ASN A 470
VAL A 471
HIS A 498
 None
 0.53A 4ffwA-1lnsA:
8.2		 4ffwA-1lnsA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		6 / 12 TYR A 210
SER A 348
TYR A 380
ASN A 470
VAL A 471
HIS A 498
 None
 0.68A 4ffwA-1lnsA:
8.2		 4ffwA-1lnsA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 12 GLU A 396
SER A 348
TYR A 380
VAL A 471
HIS A 498
 None
 0.44A 4ffwB-1lnsA:
7.4		 4ffwB-1lnsA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 12 TYR A 210
SER A 348
TYR A 380
VAL A 471
HIS A 498
 None
 0.66A 4ffwB-1lnsA:
7.4		 4ffwB-1lnsA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		3 / 3 LYS A 481
ILE A 462
THR A 359
 None
 0.86A 4gh8A-1lnsA:
undetectable		 4gh8A-1lnsA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 7 TYR A 729
ASN A 587
GLU A 734
TYR A 582
 None
 1.21A 4mi4A-1lnsA:
0.0
4mi4C-1lnsA:
0.0		 4mi4A-1lnsA:
14.04
4mi4C-1lnsA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8J_A_ADNA401_1
(RNA 3'-TERMINAL
PHOSPHATE CYCLASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 12 LEU A 680
GLN A 635
PHE A 586
ASP A 732
HIS A 735
 None
 1.13A 4o8jA-1lnsA:
0.0		 4o8jA-1lnsA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8J_B_ADNB401_1
(RNA 3'-TERMINAL
PHOSPHATE CYCLASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 12 LEU A 680
GLN A 635
PHE A 586
ASP A 732
HIS A 735
 None
 1.08A 4o8jB-1lnsA:
0.0		 4o8jB-1lnsA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 12 LEU A 621
VAL A 617
LEU A 711
ILE A 755
LEU A 560
 None
 1.04A 4p65F-1lnsA:
undetectable
4p65H-1lnsA:
undetectable
4p65K-1lnsA:
undetectable
4p65L-1lnsA:
undetectable		 4p65F-1lnsA:
4.01
4p65H-1lnsA:
4.01
4p65K-1lnsA:
2.72
4p65L-1lnsA:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 8 LEU A 273
VAL A 204
LEU A 369
TYR A 271
 None
 1.03A 4puoC-1lnsA:
undetectable		 4puoC-1lnsA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		3 / 3 TYR A 477
GLY A 615
PRO A 616
 None
 0.40A 4qwpA-1lnsA:
0.0		 4qwpA-1lnsA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		3 / 3 GLU A 746
ALA A 568
PHE A 567
 None
 0.65A 4v1fA-1lnsA:
undetectable		 4v1fA-1lnsA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		3 / 3 GLU A 746
ALA A 568
PHE A 567
 None
 0.66A 4v1fC-1lnsA:
undetectable		 4v1fC-1lnsA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 5 LEU A 223
ALA A 403
THR A 405
ILE A 214
 None
 0.89A 4xe3B-1lnsA:
undetectable		 4xe3B-1lnsA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_A_ACTA403_0
(3C-LIKE PROTEINASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 5 TYR A 381
SER A 301
LEU A 401
MET A 429
 None
 1.39A 4yo9A-1lnsA:
0.0
4yo9B-1lnsA:
0.0		 4yo9A-1lnsA:
16.95
4yo9B-1lnsA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 7 LEU A 619
ALA A 634
LEU A 711
LEU A 754
 None
 0.63A 4z90F-1lnsA:
0.0
4z90G-1lnsA:
0.0
4z90H-1lnsA:
0.0
4z90J-1lnsA:
0.0		 4z90F-1lnsA:
17.57
4z90G-1lnsA:
17.57
4z90H-1lnsA:
17.57
4z90J-1lnsA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 6 ASP A 275
THR A 270
THR A 206
SER A 284
 None
 1.48A 5b6iB-1lnsA:
1.6		 5b6iB-1lnsA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 6 PHE A   6
HIS A 490
PRO A 531
LEU A 528
 None
 1.03A 5dzka-1lnsA:
0.8
5dzko-1lnsA:
undetectable		 5dzka-1lnsA:
15.92
5dzko-1lnsA:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 9 GLY A 392
GLY A 391
ASP A 732
HIS A 735
ASN A 587
 None
 1.44A 5f8yB-1lnsA:
undetectable		 5f8yB-1lnsA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_B_RAUB400_1
(IMINE REDUCTASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 11 VAL A 313
LEU A 365
MET A 344
MET A 205
GLY A 361
 None
 1.50A 5g6sB-1lnsA:
1.3
5g6sC-1lnsA:
1.6		 5g6sB-1lnsA:
18.29
5g6sC-1lnsA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_D_RAUD400_1
(IMINE REDUCTASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 10 VAL A 313
LEU A 365
MET A 344
MET A 205
GLY A 361
 None
 1.49A 5g6sD-1lnsA:
1.6
5g6sF-1lnsA:
1.6		 5g6sD-1lnsA:
18.29
5g6sF-1lnsA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_E_RAUE400_1
(IMINE REDUCTASE)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 11 VAL A 313
LEU A 365
MET A 344
MET A 205
GLY A 361
 None
 1.49A 5g6sE-1lnsA:
1.6
5g6sH-1lnsA:
1.7		 5g6sE-1lnsA:
18.29
5g6sH-1lnsA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 6 HIS A 464
GLU A 474
LEU A 483
TYR A 449
 None
 0.60A 5igiA-1lnsA:
undetectable		 5igiA-1lnsA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		5 / 8 ALA A  78
LEU A  37
LEU A  69
LEU A  51
LEU A  41
 None
 1.23A 5jqbA-1lnsA:
undetectable
5jqbB-1lnsA:
undetectable		 5jqbA-1lnsA:
17.80
5jqbB-1lnsA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 4 PHE A 570
LEU A 711
LEU A 632
VAL A 726
 None
 1.20A 5xxiA-1lnsA:
undetectable		 5xxiA-1lnsA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		7 / 12 GLU A 396
SER A 348
TYR A 349
TYR A 380
ASN A 470
VAL A 471
HIS A 498
 None
 0.69A 6b1eB-1lnsA:
19.8		 6b1eB-1lnsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		7 / 12 TYR A 210
SER A 348
TYR A 349
TYR A 380
ASN A 470
VAL A 471
HIS A 498
 None
 0.65A 6b1eB-1lnsA:
19.8		 6b1eB-1lnsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 7 ILE A 462
VAL A 460
ALA A 358
THR A 359
 None
 0.90A 6cduC-1lnsA:
0.0
6cduD-1lnsA:
undetectable		 6cduC-1lnsA:
17.91
6cduD-1lnsA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 8 ILE A 462
VAL A 460
ALA A 358
THR A 359
 None
 0.91A 6cduD-1lnsA:
undetectable
6cduE-1lnsA:
undetectable		 6cduD-1lnsA:
17.91
6cduE-1lnsA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 7 ALA A 358
THR A 359
ILE A 462
VAL A 460
 None
 0.92A 6cduF-1lnsA:
undetectable
6cduJ-1lnsA:
undetectable		 6cduF-1lnsA:
17.91
6cduJ-1lnsA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE
(Lactococcus
lactis) 		4 / 8 ALA A 343
GLY A 364
LEU A 365
ALA A 458
 None
 0.54A 6mdqA-1lnsA:
1.3		 6mdqA-1lnsA:
7.68