SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lo3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lo3 IG GAMMA 2A HEAVY
CHAIN
(Mus
musculus) 		4 / 8 SER Y  25
ASN Y  79
ILE Y  80
GLY Y 110
 None
 0.67A 1me7A-1lo3Y:
undetectable		 1me7A-1lo3Y:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lo3 IG GAMMA 2A HEAVY
CHAIN
(Mus
musculus) 		5 / 10 SER Y  25
ASN Y  79
ILE Y  80
GLY Y 110
GLU Y   6
 None
 1.08A 1mehA-1lo3Y:
undetectable		 1mehA-1lo3Y:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lo3 IG GAMMA 2A HEAVY
CHAIN
(Mus
musculus) 		4 / 8 SER Y  25
ASN Y  79
ILE Y  80
GLY Y 110
 None
 0.74A 1meiA-1lo3Y:
undetectable		 1meiA-1lo3Y:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 1lo3 IG GAMMA 2A HEAVY
CHAIN
(Mus
musculus) 		3 / 3 THR Y 116
GLU Y 154
HIS Y 205
 None
 0.78A 3g1uB-1lo3Y:
undetectable		 3g1uB-1lo3Y:
19.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1lo3 IG GAMMA 2A HEAVY
CHAIN
(Mus
musculus) 		5 / 10 TRP Y  47
SER Y  50
TYR Y  61
GLY Y 101
TRP Y 109
 None
AN1  Y 500 ( 4.7A)
AN1  Y 500 ( 4.8A)
AN1  Y 500 ( 3.7A)
None
 0.71A 3ls4H-1lo3Y:
26.9		 3ls4H-1lo3Y:
81.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1lo3 IG GAMMA 2A HEAVY
CHAIN
(Mus
musculus) 		4 / 5 TYR Y  96
LEU Y  83
LEU Y  88
ARG Y  69
 None
 1.23A 4em2A-1lo3Y:
undetectable		 4em2A-1lo3Y:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1lo3 IG GAMMA 2A HEAVY
CHAIN
(Mus
musculus) 		5 / 8 VAL Y 127
ALA Y 124
THR Y 210
VAL Y 156
VAL Y 203
 None
 1.47A 5l94A-1lo3Y:
undetectable		 5l94A-1lo3Y:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lo3 IG GAMMA 2A HEAVY
CHAIN
(Mus
musculus) 		4 / 5 ILE Y  66
PHE Y  70
TYR Y  96
THR Y  40
 None
 1.30A 5z84N-1lo3Y:
undetectable
5z84W-1lo3Y:
0.0		 5z84N-1lo3Y:
18.64
5z84W-1lo3Y:
16.82