SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lo9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 1lo9 4-HYDROXYBENZOYL-COA
THIOESTERASE
(Pseudomonas
sp.
CBS3) 		5 / 12 LEU A  44
ILE A  80
THR A  82
ARG A   3
MET A   7
 None
 1.01A 1crbA-1lo9A:
1.0		 1crbA-1lo9A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1lo9 4-HYDROXYBENZOYL-COA
THIOESTERASE
(Pseudomonas
sp.
CBS3) 		4 / 8 ASP A  76
ALA A  72
GLY A  20
ILE A  11
 None
 0.69A 1hshD-1lo9A:
undetectable		 1hshD-1lo9A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 1lo9 4-HYDROXYBENZOYL-COA
THIOESTERASE
(Pseudomonas
sp.
CBS3) 		4 / 7 PHE A  39
TYR A  38
VAL A  93
VAL A 132
 None
 0.96A 2qbnA-1lo9A:
undetectable		 2qbnA-1lo9A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1lo9 4-HYDROXYBENZOYL-COA
THIOESTERASE
(Pseudomonas
sp.
CBS3) 		5 / 12 ILE A  56
GLY A  58
LEU A  44
PHE A  92
PRO A 133
 None
BCA  A 170 ( 3.9A)
None
None
None
 1.11A 2y7kD-1lo9A:
undetectable		 2y7kD-1lo9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1lo9 4-HYDROXYBENZOYL-COA
THIOESTERASE
(Pseudomonas
sp.
CBS3) 		5 / 11 SER A  97
VAL A 110
PHE A  68
VAL A  69
HIS A  28
 None
 1.23A 3rf4A-1lo9A:
undetectable
3rf4C-1lo9A:
undetectable		 3rf4A-1lo9A:
22.07
3rf4C-1lo9A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1lo9 4-HYDROXYBENZOYL-COA
THIOESTERASE
(Pseudomonas
sp.
CBS3) 		5 / 11 HIS A  28
SER A  97
VAL A 110
PHE A  68
VAL A  69
 None
 1.24A 3rf4B-1lo9A:
0.0
3rf4C-1lo9A:
undetectable		 3rf4B-1lo9A:
22.07
3rf4C-1lo9A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1lo9 4-HYDROXYBENZOYL-COA
THIOESTERASE
(Pseudomonas
sp.
CBS3) 		4 / 7 LEU A  44
ILE A  80
THR A  82
MET A   7
 None
 0.87A 5ljcA-1lo9A:
1.0		 5ljcA-1lo9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1lo9 4-HYDROXYBENZOYL-COA
THIOESTERASE
(Pseudomonas
sp.
CBS3) 		4 / 4 VAL A 110
VAL A  98
TYR A  27
GLN A   9
 None
 1.15A 5qggA-1lo9A:
0.4		 5qggA-1lo9A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1lo9 4-HYDROXYBENZOYL-COA
THIOESTERASE
(Pseudomonas
sp.
CBS3) 		4 / 4 VAL A 110
VAL A  98
TYR A  27
GLN A   9
 None
 1.11A 5qgoA-1lo9A:
0.4		 5qgoA-1lo9A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1lo9 4-HYDROXYBENZOYL-COA
THIOESTERASE
(Pseudomonas
sp.
CBS3) 		4 / 4 VAL A 110
VAL A  98
TYR A  27
GLN A   9
 None
 1.10A 5qgpA-1lo9A:
0.4		 5qgpA-1lo9A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1lo9 4-HYDROXYBENZOYL-COA
THIOESTERASE
(Pseudomonas
sp.
CBS3) 		4 / 4 VAL A 110
VAL A  98
TYR A  27
GLN A   9
 None
 1.16A 5qhbA-1lo9A:
0.2		 5qhbA-1lo9A:
17.86