SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1los'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 GLY A  99
LEU A 149
VAL A 151
ALA A  74
ASN A  80
 None
 1.39A 1fpqA-1losA:
undetectable		 1fpqA-1losA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A 167
LEU A 164
ALA A 139
ILE A 142
ILE A 178
 None
 1.12A 1tw4A-1losA:
undetectable		 1tw4A-1losA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 ALA A 198
ASP A 197
GLY A 156
ALA A  18
ILE A  16
 None
None
None
UP6  A5001 (-3.7A)
None
 0.99A 3ekwA-1losA:
undetectable		 3ekwA-1losA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 ARG A   4
ASP A   7
ASP A 174
ARG A 168
 None
 1.24A 3naiA-1losA:
undetectable		 3naiA-1losA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 ARG A   4
ASP A   7
ASP A 174
ARG A 168
 None
 1.33A 3naiC-1losA:
undetectable		 3naiC-1losA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLY A  91
ALA A  92
ASP A  93
ILE A  55
 None
 0.67A 3t3cA-1losA:
undetectable		 3t3cA-1losA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 GLY A 156
ARG A   5
ILE A 178
LEU A 123
 None
 1.01A 4ac9C-1losA:
2.8		 4ac9C-1losA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 GLY A 156
ARG A   5
ILE A 178
LEU A 123
 None
 1.01A 4acaC-1losA:
3.2		 4acaC-1losA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 GLY A 156
ARG A   5
ILE A 178
LEU A 123
 None
 1.01A 4acbC-1losA:
3.1		 4acbC-1losA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 LEU A  21
ALA A  18
VAL A  34
ILE A  38
 None
UP6  A5001 (-3.7A)
None
None
 0.89A 4xe3A-1losA:
undetectable		 4xe3A-1losA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 LEU A 167
ARG A 166
ARG A 163
 None
 0.88A 4yiaB-1losA:
undetectable		 4yiaB-1losA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 PHE A 100
ILE A 135
ASP A 140
 None
 0.67A 5cswA-1losA:
undetectable		 5cswA-1losA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 PHE A 100
ILE A 135
ASP A 140
 None
 0.66A 5cswB-1losA:
undetectable		 5cswB-1losA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 GLY A 217
GLU A 220
TYR A  37
ILE A  38
 None
 0.74A 5kmfA-1losA:
undetectable
5kmfC-1losA:
undetectable		 5kmfA-1losA:
21.90
5kmfC-1losA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLY A  91
ALA A  92
ASP A  93
ILE A  55
 None
 0.66A 5kqyB-1losA:
undetectable		 5kqyB-1losA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 HIS A 128
TYR A 206
ILE A 205
ALA A 203
VAL A 201
 None
None
None
UP6  A5001 (-3.3A)
UP6  A5001 ( 4.5A)
 1.10A 5n0sA-1losA:
undetectable		 5n0sA-1losA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 HIS A 128
TYR A 206
ILE A 205
ALA A 203
VAL A 201
 None
None
None
UP6  A5001 (-3.3A)
UP6  A5001 ( 4.5A)
 1.11A 5n0sB-1losA:
undetectable		 5n0sB-1losA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 HIS A 128
TYR A 206
ILE A 205
ALA A 203
VAL A 201
 None
None
None
UP6  A5001 (-3.3A)
UP6  A5001 ( 4.5A)
 1.08A 5n0xA-1losA:
undetectable		 5n0xA-1losA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 THR A  87
ALA A  69
LYS A  42
 None
None
UP6  A5001 (-2.8A)
 0.66A 6fgcA-1losA:
undetectable		 6fgcA-1losA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 THR A  87
ALA A  69
LYS A  42
 None
None
UP6  A5001 (-2.8A)
 0.62A 6fgdA-1losA:
undetectable		 6fgdA-1losA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 MET A  19
ALA A 208
LEU A 207
ALA A 203
 None
None
None
UP6  A5001 (-3.3A)
 1.10A 6fosB-1losA:
undetectable		 6fosB-1losA:
16.96