SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lox'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 7 HIS A 361
HIS A 541
HIS A 366
LEU A 597
 FE2  A 840 (-3.3A)
FE2  A 840 ( 3.4A)
FE2  A 840 (-3.4A)
RS7  A 841 (-3.4A)
 1.10A 1am6A-1loxA:
0.0		 1am6A-1loxA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 5 LEU A  39
VAL A  22
LEU A  65
GLN A 107
 None
 0.78A 1fbmE-1loxA:
undetectable		 1fbmE-1loxA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 10 LEU A 358
ALA A 433
LEU A 281
LEU A 282
HIS A 356
 None
 1.15A 1gwrA-1loxA:
0.0		 1gwrA-1loxA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 ILE A 290
GLY A 413
ALA A 404
TRP A 145
GLY A 423
 None
None
RS7  A 841 (-3.3A)
None
None
 1.07A 1kiaA-1loxA:
undetectable		 1kiaA-1loxA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 ILE A 290
GLY A 413
ALA A 404
TRP A 145
GLY A 423
 None
None
RS7  A 841 (-3.3A)
None
None
 1.07A 1kiaB-1loxA:
undetectable		 1kiaB-1loxA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 ILE A 290
GLY A 413
ALA A 404
TRP A 145
GLY A 423
 None
None
RS7  A 841 (-3.3A)
None
None
 1.08A 1kiaC-1loxA:
undetectable		 1kiaC-1loxA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 ILE A 290
GLY A 413
ALA A 404
TRP A 145
GLY A 423
 None
None
RS7  A 841 (-3.3A)
None
None
 1.07A 1nbhB-1loxA:
undetectable		 1nbhB-1loxA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 ILE A 290
GLY A 413
ALA A 404
TRP A 145
GLY A 423
 None
None
RS7  A 841 (-3.3A)
None
None
 1.14A 1nbiA-1loxA:
undetectable		 1nbiA-1loxA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 ILE A 290
GLY A 413
ALA A 404
TRP A 145
GLY A 423
 None
None
RS7  A 841 (-3.3A)
None
None
 1.12A 1nbiB-1loxA:
undetectable		 1nbiB-1loxA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 SER A 245
PHE A 275
LEU A 234
LEU A 448
LEU A 454
 None
 1.34A 1p33C-1loxA:
undetectable		 1p33C-1loxA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 10 LEU A 358
ALA A 433
LEU A 281
LEU A 282
HIS A 356
 None
 1.15A 1pcgA-1loxA:
undetectable		 1pcgA-1loxA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 10 LEU A 358
ALA A 433
LEU A 281
LEU A 282
HIS A 356
 None
 1.15A 1pcgB-1loxA:
undetectable		 1pcgB-1loxA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKT_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 10 LEU A 358
ALA A 433
LEU A 281
LEU A 282
HIS A 356
 None
 1.25A 1qktA-1loxA:
undetectable		 1qktA-1loxA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 361
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
 0.62A 1rjoA-1loxA:
undetectable		 1rjoA-1loxA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 366
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.4A)
FE2  A 840 (-3.3A)
 0.65A 1rjoA-1loxA:
undetectable		 1rjoA-1loxA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 361
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
 0.55A 1rkyA-1loxA:
undetectable		 1rkyA-1loxA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 6 LEU A 282
PHE A 279
ALA A 280
LEU A 429
 None
 0.90A 1ukbA-1loxA:
undetectable		 1ukbA-1loxA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 361
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
 0.73A 1w2zA-1loxA:
undetectable		 1w2zA-1loxA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 366
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.4A)
FE2  A 840 (-3.3A)
 0.69A 1w2zA-1loxA:
undetectable		 1w2zA-1loxA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 361
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
 0.63A 1w2zB-1loxA:
undetectable		 1w2zB-1loxA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 366
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.4A)
FE2  A 840 (-3.3A)
 0.71A 1w2zB-1loxA:
undetectable		 1w2zB-1loxA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 361
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
 0.64A 1w2zC-1loxA:
undetectable		 1w2zC-1loxA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 366
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.4A)
FE2  A 840 (-3.3A)
 0.67A 1w2zC-1loxA:
undetectable		 1w2zC-1loxA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 361
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
 0.61A 1w2zD-1loxA:
undetectable		 1w2zD-1loxA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 366
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.4A)
FE2  A 840 (-3.3A)
 0.71A 1w2zD-1loxA:
undetectable		 1w2zD-1loxA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 PHE A 353
ARG A 364
ASN A 238
 RS7  A 841 (-4.7A)
None
None
 0.81A 1xzxX-1loxA:
undetectable		 1xzxX-1loxA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 11 GLU A 276
ALA A 277
PRO A 249
ALA A 280
PHE A 233
 None
 1.23A 2admA-1loxA:
undetectable		 2admA-1loxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 11 GLU A 276
ALA A 277
PRO A 249
ALA A 280
PHE A 233
 None
 1.21A 2admB-1loxA:
undetectable		 2admB-1loxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 11 VAL A 316
GLU A 276
ALA A 277
PRO A 249
PHE A 233
 None
 1.34A 2admB-1loxA:
undetectable		 2admB-1loxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 ARG A  64
VAL A  83
GLY A   2
 None
 0.57A 2avvE-1loxA:
undetectable		 2avvE-1loxA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 545
HIS A 541
HIS A 366
 FE2  A 840 (-3.3A)
FE2  A 840 ( 3.4A)
FE2  A 840 (-3.4A)
 0.73A 2dysN-1loxA:
0.3		 2dysN-1loxA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 8 MET A 419
PHE A 415
SER A 420
LEU A 358
 RS7  A 841 ( 4.1A)
RS7  A 841 ( 4.8A)
None
None
 1.05A 2o01A-1loxA:
0.0		 2o01A-1loxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 361
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
 0.66A 2oqeA-1loxA:
undetectable		 2oqeA-1loxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 366
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.4A)
FE2  A 840 (-3.3A)
 0.69A 2oqeA-1loxA:
undetectable		 2oqeA-1loxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 361
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
 0.66A 2oqeB-1loxA:
undetectable		 2oqeB-1loxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 366
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.4A)
FE2  A 840 (-3.3A)
 0.67A 2oqeB-1loxA:
undetectable		 2oqeB-1loxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 361
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
 0.63A 2oqeC-1loxA:
undetectable		 2oqeC-1loxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 366
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.4A)
FE2  A 840 (-3.3A)
 0.69A 2oqeC-1loxA:
undetectable		 2oqeC-1loxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 361
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
 0.65A 2oqeD-1loxA:
undetectable		 2oqeD-1loxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 366
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.4A)
FE2  A 840 (-3.3A)
 0.68A 2oqeD-1loxA:
undetectable		 2oqeD-1loxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 361
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
 0.65A 2oqeF-1loxA:
undetectable		 2oqeF-1loxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 366
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.4A)
FE2  A 840 (-3.3A)
 0.68A 2oqeF-1loxA:
undetectable		 2oqeF-1loxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 PRO A 648
ASN A 642
ARG A 641
 None
 1.03A 2qeuB-1loxA:
0.0		 2qeuB-1loxA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 361
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
 0.64A 2w0qA-1loxA:
undetectable		 2w0qA-1loxA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 361
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
 0.65A 2w0qB-1loxA:
undetectable		 2w0qB-1loxA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 4 HIS A 361
HIS A 541
HIS A 545
HIS A 366
 FE2  A 840 (-3.3A)
FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.4A)
 1.07A 2wkoA-1loxA:
2.2		 2wkoA-1loxA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 5 LEU A 549
GLN A 590
THR A 553
HIS A 545
 None
None
None
FE2  A 840 (-3.3A)
 1.28A 2zj0B-1loxA:
undetectable		 2zj0B-1loxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 5 LEU A 549
GLN A 590
THR A 553
HIS A 545
 None
None
None
FE2  A 840 (-3.3A)
 1.31A 2zj0C-1loxA:
undetectable		 2zj0C-1loxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 5 ILE A 503
TYR A 439
MET A 532
THR A 531
 None
 1.28A 3abkN-1loxA:
0.9
3abkW-1loxA:
0.0		 3abkN-1loxA:
21.60
3abkW-1loxA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 5 LEU A 549
GLN A 590
THR A 553
HIS A 545
 None
None
None
FE2  A 840 (-3.3A)
 1.34A 3ce6B-1loxA:
undetectable		 3ce6B-1loxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 7 LEU A 304
ARG A 349
SER A 458
GLY A 236
 None
 1.08A 3hcnA-1loxA:
undetectable		 3hcnA-1loxA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 361
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
 0.63A 3hiiA-1loxA:
undetectable		 3hiiA-1loxA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 366
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.4A)
FE2  A 840 (-3.3A)
 0.71A 3hiiA-1loxA:
undetectable		 3hiiA-1loxA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 361
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
 0.62A 3hiiB-1loxA:
undetectable		 3hiiB-1loxA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 541
HIS A 366
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.4A)
FE2  A 840 (-3.3A)
 0.73A 3hiiB-1loxA:
undetectable		 3hiiB-1loxA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 539
SER A 542
SER A 660
ILE A 472
LEU A 468
 None
 1.23A 3iv6D-1loxA:
undetectable		 3iv6D-1loxA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 LYS A 171
ILE A 414
PHE A 415
 None
None
RS7  A 841 ( 4.8A)
 0.86A 3j7zS-1loxA:
0.8
3j7za-1loxA:
undetectable		 3j7zS-1loxA:
9.37
3j7za-1loxA:
2.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 539
GLN A 540
ARG A 364
LEU A 466
ILE A 638
 None
 1.30A 3mneA-1loxA:
undetectable		 3mneA-1loxA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 GLY A 539
GLN A 540
ARG A 364
LEU A 466
ILE A 638
 None
 1.35A 3mnpA-1loxA:
undetectable		 3mnpA-1loxA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 VAL A 456
SER A 459
LEU A 453
 None
 0.74A 3n8xA-1loxA:
0.0		 3n8xA-1loxA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 LEU A 358
ALA A 433
LEU A 281
LEU A 282
HIS A 356
 None
 1.21A 3olsB-1loxA:
undetectable		 3olsB-1loxA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 LEU A 358
ALA A 433
LEU A 281
LEU A 282
HIS A 356
 None
 1.13A 3q95A-1loxA:
undetectable		 3q95A-1loxA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 545
SER A 660
GLU A 658
 FE2  A 840 (-3.3A)
None
None
 0.81A 3s8pA-1loxA:
0.0		 3s8pA-1loxA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 VAL A 101
CYH A  78
THR A  10
LEU A  39
VAL A  22
 None
 1.23A 3sp9B-1loxA:
undetectable		 3sp9B-1loxA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 11 LEU A 358
ALA A 433
LEU A 281
LEU A 282
HIS A 356
 None
 1.13A 3uudA-1loxA:
0.0		 3uudA-1loxA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 6 THR A 504
GLY A 507
ARG A 364
ILE A 150
 None
 1.17A 4ac9C-1loxA:
undetectable		 4ac9C-1loxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 6 THR A 504
GLY A 507
ARG A 364
ILE A 150
 None
 1.19A 4acaC-1loxA:
undetectable		 4acaC-1loxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 ARG A 349
TRP A 551
GLY A 236
 None
 0.68A 4e7cA-1loxA:
0.0		 4e7cA-1loxA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 9 TYR A  56
GLY A  28
LEU A  26
VAL A  83
VAL A  63
 None
 1.20A 4mjrA-1loxA:
undetectable		 4mjrA-1loxA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 8 HIS A 366
HIS A 361
HIS A 541
PHE A 167
 FE2  A 840 (-3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 ( 3.4A)
None
 0.87A 4n16A-1loxA:
undetectable		 4n16A-1loxA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 11 LEU A 242
ARG A 243
LEU A 274
LEU A 453
LEU A 304
 None
 1.27A 4or0A-1loxA:
0.0		 4or0A-1loxA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 11 LEU A 242
ARG A 243
LEU A 274
LEU A 453
LEU A 304
 None
 1.25A 4or0B-1loxA:
undetectable		 4or0B-1loxA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 8 LEU A  24
VAL A  83
TRP A  76
LEU A  39
 None
 1.02A 4pwdA-1loxA:
undetectable		 4pwdA-1loxA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 8 LEU A  24
VAL A  83
TRP A  76
LEU A  39
 None
 1.00A 4q0bA-1loxA:
undetectable		 4q0bA-1loxA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 ALA A  75
TRP A 100
VAL A 101
 None
 0.39A 4w9nC-1loxA:
undetectable		 4w9nC-1loxA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 4 GLY A  11
LEU A 109
PHE A  95
ILE A  81
 None
 0.92A 4xv2A-1loxA:
undetectable		 4xv2A-1loxA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 ARG A 451
ASP A 447
TYR A 461
 None
 0.95A 4yo9B-1loxA:
0.3		 4yo9B-1loxA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 LEU A 358
ALA A 433
LEU A 281
LEU A 282
HIS A 356
 None
 1.16A 4zn7A-1loxA:
0.0		 4zn7A-1loxA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 10 LEU A 358
ALA A 433
LEU A 281
LEU A 282
HIS A 356
 None
 1.17A 5dxeB-1loxA:
undetectable		 5dxeB-1loxA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 6 PHE A 275
SER A 351
VAL A 348
ASP A 278
 None
 1.30A 5hesA-1loxA:
undetectable		 5hesA-1loxA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 10 LEU A 358
ALA A 433
LEU A 281
LEU A 282
HIS A 356
 None
 1.13A 5hyrA-1loxA:
0.0		 5hyrA-1loxA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 LYS A 585
GLN A 294
ASN A 288
 None
 1.06A 5l2tA-1loxA:
0.0		 5l2tA-1loxA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 HIS A 356
HIS A 361
HIS A 545
 None
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
 0.68A 5oexA-1loxA:
undetectable		 5oexA-1loxA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 ALA A 154
GLY A 155
LEU A 398
VAL A 402
TRP A 142
 None
 1.14A 5w7pA-1loxA:
0.0		 5w7pA-1loxA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 TYR A 461
SER A 459
GLY A 236
ALA A 237
PHE A 233
 None
 0.98A 5wbvA-1loxA:
undetectable		 5wbvA-1loxA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 TYR A 461
SER A 459
GLY A 236
ALA A 237
PHE A 233
 None
 1.00A 5wbvB-1loxA:
undetectable		 5wbvB-1loxA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 4 HIS A 541
HIS A 545
HIS A 361
HIS A 366
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.4A)
 1.12A 5zrdC-1loxA:
3.8		 5zrdC-1loxA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 4 HIS A 541
HIS A 545
HIS A 361
HIS A 366
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.4A)
 1.13A 5zrdD-1loxA:
3.3		 5zrdD-1loxA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 ASN A 152
VAL A 661
HIS A 366
 None
None
FE2  A 840 (-3.4A)
 0.74A 6a5yD-1loxA:
2.0		 6a5yD-1loxA:
8.70