SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lpb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1lpb LIPASE
(Homo
sapiens) 		4 / 8 PHE B 386
ILE B 371
LEU B 359
VAL B 342
 None
 0.89A 1fslA-1lpbB:
undetectable		 1fslA-1lpbB:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 1lpb LIPASE
(Homo
sapiens) 		4 / 8 PHE B 386
ILE B 371
LEU B 359
VAL B 342
 None
 0.89A 1fslB-1lpbB:
undetectable		 1fslB-1lpbB:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 1lpb LIPASE
(Homo
sapiens) 		4 / 8 TRP B  85
GLY B  76
SER B 152
HIS B 263
 None
MUP  B 901 (-3.0A)
MUP  B 901 ( 1.6A)
MUP  B 901 ( 4.1A)
 0.97A 1maaD-1lpbB:
8.7		 1maaD-1lpbB:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 1lpb LIPASE
(Homo
sapiens) 		4 / 7 ALA B 161
VAL B 124
GLY B 150
ILE B 149
 None
 0.78A 1t7jB-1lpbB:
undetectable		 1t7jB-1lpbB:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 1lpb LIPASE
(Homo
sapiens) 		5 / 12 TYR B 270
GLY B 174
ALA B 196
ILE B  74
HIS B 147
 None
 1.09A 1ve3A-1lpbB:
undetectable		 1ve3A-1lpbB:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 1lpb LIPASE
(Homo
sapiens) 		3 / 3 ASP B 257
ARG B 265
ASP B 249
 BOG  B 452 ( 3.5A)
BOG  B 452 (-2.4A)
BOG  B 452 (-2.8A)
 0.87A 1vptA-1lpbB:
undetectable		 1vptA-1lpbB:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 1lpb LIPASE
(Homo
sapiens) 		4 / 8 ASP B 200
GLY B 170
ALA B 196
ILE B 172
 None
 0.85A 2dtjA-1lpbB:
0.0
2dtjB-1lpbB:
undetectable		 2dtjA-1lpbB:
18.34
2dtjB-1lpbB:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1lpb LIPASE
(Homo
sapiens) 		3 / 3 ALA B 155
GLY B 216
SER B 266
 None
 0.44A 2ivuA-1lpbB:
undetectable		 2ivuA-1lpbB:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 1lpb LIPASE
(Homo
sapiens) 		3 / 3 ALA B 417
VAL B 415
TRP B 402
 None
 0.94A 2izqA-1lpbB:
undetectable
2izqB-1lpbB:
undetectable		 2izqA-1lpbB:
3.70
2izqB-1lpbB:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 1lpb LIPASE
(Homo
sapiens) 		3 / 3 ASN B  92
LEU B  93
HIS B 309
 None
 0.71A 2q6fB-1lpbB:
0.0		 2q6fB-1lpbB:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1lpb LIPASE
(Homo
sapiens) 		5 / 12 PHE B 386
TYR B 340
VAL B 342
ILE B 420
SER B 388
 None
 1.05A 3apwA-1lpbB:
0.0		 3apwA-1lpbB:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 1lpb LIPASE
(Homo
sapiens) 		4 / 6 ASN B 100
ARG B  68
ASN B  63
GLU B  44
 None
 1.06A 3galA-1lpbB:
undetectable		 3galA-1lpbB:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 1lpb LIPASE
(Homo
sapiens) 		5 / 10 GLY B   9
ARG B 164
GLU B   2
LEU B   8
ILE B 123
 None
 1.31A 3kvrA-1lpbB:
undetectable		 3kvrA-1lpbB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 1lpb LIPASE
(Homo
sapiens) 		3 / 3 SER B 333
ASP B 272
ASN B  92
 BOG  B 452 (-3.5A)
None
None
 0.99A 3lsfB-1lpbB:
0.0
3lsfE-1lpbB:
0.0		 3lsfB-1lpbB:
18.93
3lsfE-1lpbB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 1lpb LIPASE
(Homo
sapiens) 		3 / 3 ASP B 272
ASN B  92
SER B 333
 None
None
BOG  B 452 (-3.5A)
 0.99A 3lsfB-1lpbB:
0.0
3lsfE-1lpbB:
0.0		 3lsfB-1lpbB:
18.93
3lsfE-1lpbB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 1lpb LIPASE
(Homo
sapiens) 		5 / 9 VAL B 104
PHE B  38
ILE B  74
ALA B 126
VAL B  34
 None
 1.02A 3me6C-1lpbB:
undetectable		 3me6C-1lpbB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 1lpb LIPASE
(Homo
sapiens) 		5 / 9 GLY B   9
ARG B 164
GLU B   2
LEU B   8
ILE B 123
 None
 1.28A 3nbqA-1lpbB:
3.6		 3nbqA-1lpbB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 1lpb LIPASE
(Homo
sapiens) 		5 / 10 ALA B 161
VAL B 124
GLY B 150
ILE B 149
VAL B 128
 None
 0.97A 3t3cB-1lpbB:
undetectable		 3t3cB-1lpbB:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1lpb LIPASE
(Homo
sapiens) 		4 / 8 PHE B 386
TYR B 340
VAL B 342
ILE B 420
 None
 0.88A 4a97D-1lpbB:
0.0		 4a97D-1lpbB:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1lpb LIPASE
(Homo
sapiens) 		4 / 7 PHE B 386
TYR B 340
VAL B 342
ILE B 420
 None
 0.85A 4a97H-1lpbB:
undetectable		 4a97H-1lpbB:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1lpb LIPASE
(Homo
sapiens) 		4 / 8 PHE B 386
TYR B 340
VAL B 342
ILE B 420
 None
 0.89A 4a97I-1lpbB:
0.0		 4a97I-1lpbB:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 1lpb LIPASE
(Homo
sapiens) 		5 / 12 ASP B 225
HIS B 156
ASP B 176
HIS B 203
GLY B 216
 None
 1.43A 4bz6A-1lpbB:
undetectable
4bz6B-1lpbB:
undetectable		 4bz6A-1lpbB:
22.75
4bz6B-1lpbB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 1lpb LIPASE
(Homo
sapiens) 		4 / 8 GLN B 306
ASN B 425
TRP B 338
THR B 329
 None
 1.44A 4d1yA-1lpbB:
2.7
4d1yB-1lpbB:
3.1		 4d1yA-1lpbB:
18.02
4d1yB-1lpbB:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1lpb LIPASE
(Homo
sapiens) 		3 / 3 ARG B 111
TRP B 106
GLY B  76
 BOG  B 450 (-3.6A)
None
MUP  B 901 (-3.0A)
 0.92A 4e7cA-1lpbB:
0.0		 4e7cA-1lpbB:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1lpb LIPASE
(Homo
sapiens) 		4 / 5 ARG B 111
TRP B 106
HIS B  75
GLY B  76
 BOG  B 450 (-3.6A)
None
None
MUP  B 901 (-3.0A)
 1.15A 4e7cC-1lpbB:
0.0		 4e7cC-1lpbB:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1lpb LIPASE
(Homo
sapiens) 		4 / 7 PHE B 198
PRO B 305
TYR B 314
PHE B 226
 None
 1.34A 4grqA-1lpbB:
0.0
4grqC-1lpbB:
0.0		 4grqA-1lpbB:
13.48
4grqC-1lpbB:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 1lpb LIPASE
(Homo
sapiens) 		4 / 5 VAL B  99
ARG B  68
GLU B  44
LEU B  40
 None
 1.43A 4hojA-1lpbB:
0.3		 4hojA-1lpbB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 1lpb LIPASE
(Homo
sapiens) 		3 / 3 HIS B 151
TRP B 106
SER B 266
 MUP  B 901 (-4.5A)
None
None
 1.14A 4lrhD-1lpbB:
undetectable		 4lrhD-1lpbB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA305_0
(THAUMATIN-1)		 1lpb LIPASE
(Homo
sapiens) 		4 / 5 LYS B 341
GLU B 385
PHE B 291
VAL B 290
 None
 1.42A 4tvtA-1lpbB:
0.0		 4tvtA-1lpbB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 1lpb LIPASE
(Homo
sapiens) 		5 / 10 ALA B 281
ASP B 278
TYR B 310
SER B 273
GLY B 279
 None
 1.43A 4xp1A-1lpbB:
undetectable		 4xp1A-1lpbB:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 1lpb LIPASE
(Homo
sapiens) 		4 / 5 HIS B 156
VAL B 148
GLY B 125
ALA B 161
 None
 1.02A 5hwaA-1lpbB:
0.0		 5hwaA-1lpbB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1lpb LIPASE
(Homo
sapiens) 		3 / 3 ARG B  71
ILE B 102
PHE B  72
 None
 0.75A 5kirA-1lpbB:
undetectable		 5kirA-1lpbB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 1lpb LIPASE
(Homo
sapiens) 		5 / 11 ARG B 111
ALA B 178
ASP B 176
GLY B 150
ILE B  74
 BOG  B 450 (-3.6A)
MUP  B 901 (-3.3A)
None
None
None
 1.21A 5kr2B-1lpbB:
undetectable		 5kr2B-1lpbB:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UWC_G_EDTG407_0
(INTERLEUKIN-3
RECEPTOR SUBUNIT
ALPHA)		 1lpb LIPASE
(Homo
sapiens) 		4 / 5 TRP B 106
HIS B  75
SER B 110
ARG B 111
 None
None
None
BOG  B 450 (-3.6A)
 1.40A 5uwcG-1lpbB:
2.3		 5uwcG-1lpbB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1lpb LIPASE
(Homo
sapiens) 		4 / 6 ILE B 169
ILE B 202
HIS B 223
PHE B 280
 None
 1.02A 5vkqB-1lpbB:
undetectable
5vkqC-1lpbB:
undetectable		 5vkqB-1lpbB:
13.48
5vkqC-1lpbB:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1lpb LIPASE
(Homo
sapiens) 		4 / 6 ILE B 169
ILE B 202
HIS B 223
PHE B 280
 None
 1.01A 5vkqC-1lpbB:
undetectable
5vkqD-1lpbB:
undetectable		 5vkqC-1lpbB:
13.48
5vkqD-1lpbB:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 1lpb LIPASE
(Homo
sapiens) 		4 / 7 ASN B 100
ARG B  68
ASN B  63
GLU B  44
 None
 1.07A 6b8kA-1lpbB:
undetectable		 6b8kA-1lpbB:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 1lpb LIPASE
(Homo
sapiens) 		4 / 8 ASN B 100
ARG B  68
ASN B  63
GLU B  44
 None
 1.10A 6b94A-1lpbB:
undetectable		 6b94A-1lpbB:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 1lpb LIPASE
(Homo
sapiens) 		5 / 12 GLU B 133
VAL B 128
GLN B 136
VAL B 148
GLY B 159
 None
 0.94A 6gneB-1lpbB:
3.5		 6gneB-1lpbB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1lpb LIPASE
(Homo
sapiens) 		4 / 5 GLY B 374
THR B 375
HIS B 382
SER B 380
 None
 1.16A 6jmjA-1lpbB:
undetectable		 6jmjA-1lpbB:
16.22