SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lpc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		5 / 10 ALA A 179
PHE A 181
GLY A 245
GLU A 177
LEU A  72
 None
None
None
CMP  A 901 (-3.9A)
None
 1.35A 1cmcA-1lpcA:
undetectable
1cmcB-1lpcA:
undetectable		 1cmcA-1lpcA:
14.96
1cmcB-1lpcA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		5 / 10 GLU A 177
LEU A  72
ALA A 179
PHE A 181
GLY A 245
 CMP  A 901 (-3.9A)
None
None
None
None
 1.40A 1cmcA-1lpcA:
undetectable
1cmcB-1lpcA:
undetectable		 1cmcA-1lpcA:
14.96
1cmcB-1lpcA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		6 / 9 PHE A  91
TYR A 121
ILE A 172
ALA A 176
GLU A 177
ARG A 180
 None
CMP  A 901 (-4.3A)
CMP  A 901 (-4.1A)
CMP  A 901 ( 4.0A)
CMP  A 901 (-3.9A)
CMP  A 901 (-3.0A)
 0.53A 1mrgA-1lpcA:
27.9		 1mrgA-1lpcA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		4 / 8 TYR A 121
ILE A 172
GLU A 177
ARG A 180
 CMP  A 901 (-4.3A)
CMP  A 901 (-4.1A)
CMP  A 901 (-3.9A)
CMP  A 901 (-3.0A)
 0.20A 1mrjA-1lpcA:
27.6		 1mrjA-1lpcA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		5 / 12 GLY A 223
GLY A  36
GLN A 243
ASP A 241
ASP A  38
 None
 1.03A 1wg8B-1lpcA:
undetectable		 1wg8B-1lpcA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		5 / 12 ALA A 178
PHE A  56
LEU A  20
PHE A  19
GLY A  66
 None
 0.99A 2ve3A-1lpcA:
0.0		 2ve3A-1lpcA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		4 / 8 LEU A   8
ILE A 151
LEU A 147
LEU A   6
 None
 0.69A 2xfhA-1lpcA:
undetectable		 2xfhA-1lpcA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		4 / 7 PHE A 231
GLY A 234
PHE A 233
PHE A 181
 None
 1.13A 3ko0D-1lpcA:
undetectable
3ko0E-1lpcA:
undetectable		 3ko0D-1lpcA:
19.29
3ko0E-1lpcA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		4 / 5 PHE A 205
ILE A 212
PHE A 231
PHE A 233
 None
 1.12A 3owxB-1lpcA:
undetectable		 3owxB-1lpcA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		6 / 10 TYR A  73
TYR A 121
ILE A 172
ALA A 176
GLU A 177
ARG A 180
 CMP  A 901 (-4.1A)
CMP  A 901 (-4.3A)
CMP  A 901 (-4.1A)
CMP  A 901 ( 4.0A)
CMP  A 901 (-3.9A)
CMP  A 901 (-3.0A)
 0.56A 3u6tA-1lpcA:
27.6		 3u6tA-1lpcA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		3 / 3 ARG A 166
GLU A 139
THR A 131
 None
 0.77A 3v4tA-1lpcA:
0.0		 3v4tA-1lpcA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		6 / 12 LEU A 168
ALA A 171
LEU A   8
LEU A 147
ILE A 148
GLY A  58
 None
 1.40A 4dm8B-1lpcA:
0.0		 4dm8B-1lpcA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		6 / 12 PHE A 167
ALA A 171
LEU A   8
LEU A 147
ILE A 148
GLY A  58
 None
 1.19A 4dm8B-1lpcA:
0.0		 4dm8B-1lpcA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		4 / 5 TYR A  73
TYR A 121
ILE A 172
ARG A 180
 CMP  A 901 (-4.1A)
CMP  A 901 (-4.3A)
CMP  A 901 (-4.1A)
CMP  A 901 (-3.0A)
 0.20A 4o0oA-1lpcA:
27.7		 4o0oA-1lpcA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		3 / 3 SER A  64
ALA A  76
VAL A  75
 None
 0.69A 4o2bC-1lpcA:
undetectable		 4o2bC-1lpcA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		5 / 9 ALA A 176
THR A 175
ALA A 179
VAL A  75
GLY A  66
 CMP  A 901 ( 4.0A)
None
None
None
None
 1.23A 4qvnK-1lpcA:
undetectable
4qvnL-1lpcA:
undetectable		 4qvnK-1lpcA:
23.62
4qvnL-1lpcA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		5 / 9 ALA A 176
THR A 175
ALA A 179
VAL A  75
GLY A  66
 CMP  A 901 ( 4.0A)
None
None
None
None
 1.23A 4qvnY-1lpcA:
undetectable
4qvnZ-1lpcA:
undetectable		 4qvnY-1lpcA:
23.62
4qvnZ-1lpcA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		3 / 3 MET A 174
GLN A  22
TYR A   4
 None
 0.69A 4udcA-1lpcA:
undetectable		 4udcA-1lpcA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		3 / 3 GLU A 177
ALA A 178
PHE A 181
 CMP  A 901 (-3.9A)
None
None
 0.52A 4v1fA-1lpcA:
0.0		 4v1fA-1lpcA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		3 / 3 GLU A 177
ALA A 178
PHE A 181
 CMP  A 901 (-3.9A)
None
None
 0.49A 4v1fC-1lpcA:
0.0		 4v1fC-1lpcA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		7 / 9 TYR A  73
PHE A  91
TYR A 121
ILE A 172
ALA A 176
GLU A 177
ARG A 180
 CMP  A 901 (-4.1A)
None
CMP  A 901 (-4.3A)
CMP  A 901 (-4.1A)
CMP  A 901 ( 4.0A)
CMP  A 901 (-3.9A)
CMP  A 901 (-3.0A)
 0.58A 4yp2B-1lpcA:
27.7		 4yp2B-1lpcA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		7 / 9 TYR A  73
PHE A  91
TYR A 121
ILE A 172
ALA A 176
GLU A 177
ARG A 180
 CMP  A 901 (-4.1A)
None
CMP  A 901 (-4.3A)
CMP  A 901 (-4.1A)
CMP  A 901 ( 4.0A)
CMP  A 901 (-3.9A)
CMP  A 901 (-3.0A)
 0.57A 5cf9B-1lpcA:
27.7		 5cf9B-1lpcA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		5 / 12 LEU A   8
PHE A  56
LEU A  67
LEU A   6
ALA A 178
 None
 1.21A 5ienB-1lpcA:
undetectable		 5ienB-1lpcA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		6 / 6 TYR A  73
VAL A  74
TYR A 121
ILE A 172
GLU A 177
ARG A 180
 CMP  A 901 (-4.1A)
CMP  A 901 (-4.0A)
CMP  A 901 (-4.3A)
CMP  A 901 (-4.1A)
CMP  A 901 (-3.9A)
CMP  A 901 (-3.0A)
 0.56A 5z3jA-1lpcA:
28.1		 5z3jA-1lpcA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		3 / 3 TYR A  73
ALA A 179
LEU A 246
 CMP  A 901 (-4.1A)
None
None
 0.59A 6ag0C-1lpcA:
undetectable		 6ag0C-1lpcA:
15.71