SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lpe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1lpe APOLIPOPROTEIN E3
(Homo
sapiens) 		4 / 8 GLU A 121
LEU A 133
LEU A 137
ARG A 114
 None
 0.72A 1ereE-1lpeA:
undetectable		 1ereE-1lpeA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 1lpe APOLIPOPROTEIN E3
(Homo
sapiens) 		4 / 8 GLU A 121
LEU A 133
LEU A 137
ARG A 114
 None
 0.74A 1ereF-1lpeA:
undetectable		 1ereF-1lpeA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1lpe APOLIPOPROTEIN E3
(Homo
sapiens) 		4 / 4 THR A  67
LEU A  71
LEU A  78
GLN A  81
 None
 0.66A 1fbmA-1lpeA:
undetectable		 1fbmA-1lpeA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1lpe APOLIPOPROTEIN E3
(Homo
sapiens) 		4 / 5 THR A  67
LEU A  71
LEU A  78
GLN A  81
 None
 0.69A 1fbmE-1lpeA:
undetectable		 1fbmE-1lpeA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 1lpe APOLIPOPROTEIN E3
(Homo
sapiens) 		5 / 12 LEU A  51
GLU A 121
LEU A 133
LEU A 137
ARG A 114
 None
 1.18A 1g50B-1lpeA:
2.5		 1g50B-1lpeA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 1lpe APOLIPOPROTEIN E3
(Homo
sapiens) 		5 / 11 LEU A  51
GLU A 121
LEU A 133
LEU A 137
ARG A 114
 None
 1.18A 1g50C-1lpeA:
1.3		 1g50C-1lpeA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1lpe APOLIPOPROTEIN E3
(Homo
sapiens) 		4 / 6 LEU A  52
GLU A 121
LEU A 133
LEU A  43
 None
 0.84A 1mt1D-1lpeA:
undetectable
1mt1E-1lpeA:
undetectable		 1mt1D-1lpeA:
20.00
1mt1E-1lpeA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1lpe APOLIPOPROTEIN E3
(Homo
sapiens) 		3 / 3 THR A  67
LEU A  71
LEU A  78
 None
 0.62A 1mz9C-1lpeA:
undetectable		 1mz9C-1lpeA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1lpe APOLIPOPROTEIN E3
(Homo
sapiens) 		5 / 11 ARG A  38
LEU A  37
LYS A 146
ALA A 138
LEU A 141
 None
 1.15A 4wg0B-1lpeA:
undetectable
4wg0C-1lpeA:
undetectable
4wg0D-1lpeA:
undetectable		 4wg0B-1lpeA:
6.82
4wg0C-1lpeA:
6.82
4wg0D-1lpeA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1lpe APOLIPOPROTEIN E3
(Homo
sapiens) 		5 / 11 ARG A  38
LEU A  37
LYS A 146
ALA A 138
LEU A 141
 None
 1.16A 4wg0D-1lpeA:
undetectable
4wg0E-1lpeA:
undetectable
4wg0F-1lpeA:
undetectable		 4wg0D-1lpeA:
6.82
4wg0E-1lpeA:
6.82
4wg0F-1lpeA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1lpe APOLIPOPROTEIN E3
(Homo
sapiens) 		3 / 3 VAL A  47
LEU A  51
VAL A  56
 None
 0.57A 4wq4A-1lpeA:
2.1		 4wq4A-1lpeA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1lpe APOLIPOPROTEIN E3
(Homo
sapiens) 		5 / 7 ARG A 114
VAL A 111
LEU A  60
LEU A 141
LEU A 137
 None
 1.24A 5jq7A-1lpeA:
undetectable		 5jq7A-1lpeA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1lpe APOLIPOPROTEIN E3
(Homo
sapiens) 		5 / 8 ARG A 114
LEU A 141
LEU A 137
LEU A  60
LEU A  37
 None
 1.14A 5jqbA-1lpeA:
undetectable
5jqbB-1lpeA:
0.8		 5jqbA-1lpeA:
18.79
5jqbB-1lpeA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 1lpe APOLIPOPROTEIN E3
(Homo
sapiens) 		5 / 12 GLU A 121
LEU A 133
LEU A 137
ARG A 114
LEU A  43
 None
 1.03A 5toaB-1lpeA:
3.0		 5toaB-1lpeA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 1lpe APOLIPOPROTEIN E3
(Homo
sapiens) 		4 / 6 GLY A 165
SER A  94
THR A  89
VAL A  85
 None
 0.94A 5ysiA-1lpeA:
0.0		 5ysiA-1lpeA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 1lpe APOLIPOPROTEIN E3
(Homo
sapiens) 		5 / 10 LEU A 155
LEU A  93
GLY A  23
GLY A 165
VAL A 161
 None
 1.21A 6eu9B-1lpeA:
undetectable		 6eu9B-1lpeA:
21.62