SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lpf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 6 LEU A 414
ASP A 411
LEU A 351
HIS A 417
 None
 1.14A 1errB-1lpfA:
undetectable		 1errB-1lpfA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 5 SER A  63
GLU A 194
TYR A 357
SER A 170
 None
None
FAD  A 480 ( 4.7A)
FAD  A 480 ( 3.7A)
 1.24A 1vidA-1lpfA:
2.9		 1vidA-1lpfA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 7 LEU A 174
GLY A 172
LEU A 195
PRO A 180
 None
 0.93A 1ya4B-1lpfA:
undetectable		 1ya4B-1lpfA:
24.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 THR A 383
GLN A 222
LEU A 426
ILE A 362
HIS A 359
 None
 1.20A 2g72B-1lpfA:
undetectable		 2g72B-1lpfA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 5 LEU A 414
ASP A 411
LEU A 351
HIS A 417
 None
 1.20A 2jfaA-1lpfA:
undetectable		 2jfaA-1lpfA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 7 MET A 347
ARG A 321
ILE A 352
GLU A 331
 None
 1.44A 2nsiC-1lpfA:
undetectable
2nsiD-1lpfA:
undetectable		 2nsiC-1lpfA:
20.93
2nsiD-1lpfA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 7 GLU A 331
MET A 347
ARG A 321
ILE A 352
 None
 1.46A 2nsiC-1lpfA:
0.0
2nsiD-1lpfA:
0.0		 2nsiC-1lpfA:
20.93
2nsiD-1lpfA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 5 LEU A 414
ASP A 411
LEU A 351
HIS A 417
 None
 1.19A 2qxsA-1lpfA:
undetectable		 2qxsA-1lpfA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 5 LEU A 414
ASP A 411
LEU A 351
HIS A 417
 None
 1.17A 2qxsB-1lpfA:
undetectable		 2qxsB-1lpfA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		3 / 3 GLU A 455
HIS A 470
GLU A 459
 None
 0.82A 2x45B-1lpfA:
0.5		 2x45B-1lpfA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		3 / 3 GLU A 455
HIS A 470
GLU A 459
 None
 0.87A 2x45C-1lpfA:
0.4		 2x45C-1lpfA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 8 LEU A 236
GLY A 189
ALA A 188
ILE A 362
ILE A 238
 None
 1.16A 3ekpA-1lpfA:
undetectable		 3ekpA-1lpfA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 8 LEU A 212
GLY A 192
ALA A 275
ILE A 157
 None
 0.74A 3jusA-1lpfA:
0.0		 3jusA-1lpfA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 8 LEU A 212
GLY A 192
ALA A 275
ILE A 157
 None
 0.74A 3jusA-1lpfA:
0.0		 3jusA-1lpfA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 8 LEU A 212
GLY A 192
ALA A 275
ILE A 157
 None
 0.78A 3jusB-1lpfA:
undetectable		 3jusB-1lpfA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 10 VAL A 254
VAL A 256
LEU A 209
SER A 247
GLY A 184
 None
 1.26A 3ls4H-1lpfA:
undetectable		 3ls4H-1lpfA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 LEU A 236
GLY A 189
ALA A 188
ILE A 362
ILE A 238
 None
 1.05A 3mwsA-1lpfA:
undetectable		 3mwsA-1lpfA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 5 LEU A 231
SER A 197
ARG A 201
LEU A 193
 None
 1.16A 3onnA-1lpfA:
0.0		 3onnA-1lpfA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		3 / 3 TYR A 301
LEU A 124
LYS A 127
 None
 0.72A 3sueD-1lpfA:
0.0		 3sueD-1lpfA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 GLY A  37
GLY A  40
GLU A 118
ALA A  43
ASN A  50
 None
 1.33A 3t7sA-1lpfA:
2.2		 3t7sA-1lpfA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 GLY A  37
GLY A  40
GLU A 118
ALA A  43
ASN A  50
 None
 1.32A 3t7sB-1lpfA:
2.1		 3t7sB-1lpfA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 GLY A  37
GLY A  40
GLU A 118
ALA A  43
ASN A  50
 None
 1.32A 3t7sC-1lpfA:
2.2		 3t7sC-1lpfA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 GLY A  37
GLY A  40
GLU A 118
ALA A  43
ASN A  50
 None
 1.31A 3t7sD-1lpfA:
2.1		 3t7sD-1lpfA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		3 / 3 ARG A 339
PRO A 311
PHE A 314
 None
 0.73A 3thrC-1lpfA:
1.8		 3thrC-1lpfA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 8 GLY A 189
GLY A 187
GLY A 196
ILE A 273
LEU A 183
 None
 1.31A 3v1nA-1lpfA:
undetectable		 3v1nA-1lpfA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 11 GLY A 317
GLY A 151
ILE A 148
ASP A 318
PRO A  13
 FAD  A 480 (-3.4A)
FAD  A 480 (-3.4A)
None
FAD  A 480 (-2.9A)
FAD  A 480 (-3.5A)
 1.10A 4dcmA-1lpfA:
3.8		 4dcmA-1lpfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 7 GLY A 192
ILE A 238
LEU A 231
PHE A 215
 None
 0.66A 4ejjD-1lpfA:
0.0		 4ejjD-1lpfA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_B_SVRB301_1
(NUCLEOCAPSID PROTEIN)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 10 GLY A 192
ARG A 201
ALA A 200
VAL A 208
PHE A 215
 None
 1.34A 4j4vB-1lpfA:
0.7		 4j4vB-1lpfA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 11 GLY A 192
ARG A 201
ALA A 200
VAL A 208
PHE A 215
 None
 1.38A 4j4vD-1lpfA:
0.9
4j4vE-1lpfA:
0.1		 4j4vD-1lpfA:
20.62
4j4vE-1lpfA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 8 ALA A  18
VAL A 336
GLY A 317
VAL A 146
ILE A 147
 None
None
FAD  A 480 (-3.4A)
None
None
 1.37A 4ll3A-1lpfA:
undetectable		 4ll3A-1lpfA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		3 / 3 VAL A 402
ALA A 423
PHE A 386
 None
 0.93A 4w5nA-1lpfA:
undetectable		 4w5nA-1lpfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 GLU A 226
GLY A 382
ALA A 463
GLU A 459
ILE A 471
 None
 1.25A 4xe5A-1lpfA:
3.4		 4xe5A-1lpfA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 8 ALA A 149
VAL A   8
GLY A  14
ALA A 329
GLY A 333
 FAD  A 480 (-4.8A)
None
FAD  A 480 (-3.8A)
FAD  A 480 ( 4.0A)
None
 1.26A 4zjzB-1lpfA:
2.5		 4zjzB-1lpfA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 7 ILE A 105
LEU A  49
GLY A  46
GLY A  45
 None
None
FAD  A 480 (-3.1A)
None
 0.80A 5a06A-1lpfA:
undetectable		 5a06A-1lpfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 7 ILE A 105
LEU A  49
GLY A  46
GLY A  45
 None
None
FAD  A 480 (-3.1A)
None
 0.80A 5a06B-1lpfA:
undetectable		 5a06B-1lpfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 7 ILE A 105
LEU A  49
GLY A  46
GLY A  45
 None
None
FAD  A 480 (-3.1A)
None
 0.80A 5a06C-1lpfA:
undetectable		 5a06C-1lpfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 7 ILE A 105
LEU A  49
GLY A  46
GLY A  45
 None
None
FAD  A 480 (-3.1A)
None
 0.80A 5a06E-1lpfA:
undetectable		 5a06E-1lpfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 7 ILE A 105
LEU A  49
GLY A  46
GLY A  45
 None
None
FAD  A 480 (-3.1A)
None
 0.78A 5a06F-1lpfA:
2.0		 5a06F-1lpfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 5 SER A  63
GLU A 194
TYR A 357
SER A 170
 None
None
FAD  A 480 ( 4.7A)
FAD  A 480 ( 3.7A)
 1.25A 5fhrA-1lpfA:
2.6		 5fhrA-1lpfA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 GLY A 184
LEU A 183
VAL A  51
GLY A 196
LEU A 209
 None
 1.12A 5hg0B-1lpfA:
undetectable		 5hg0B-1lpfA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		6 / 12 SER A 354
LEU A 457
VAL A 427
GLY A 430
ALA A 431
LEU A 351
 None
 1.49A 5iktA-1lpfA:
undetectable		 5iktA-1lpfA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 10 ALA A  18
GLU A 332
ALA A  11
GLY A  12
ALA A 149
 None
None
None
FAD  A 480 (-3.5A)
FAD  A 480 (-4.8A)
 1.21A 5lf3H-1lpfA:
undetectable
5lf3I-1lpfA:
undetectable		 5lf3H-1lpfA:
18.83
5lf3I-1lpfA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 10 ALA A  18
GLU A 332
ALA A  11
GLY A  12
ALA A 149
 None
None
None
FAD  A 480 (-3.5A)
FAD  A 480 (-4.8A)
 1.22A 5lf3V-1lpfA:
undetectable
5lf3W-1lpfA:
undetectable		 5lf3V-1lpfA:
18.83
5lf3W-1lpfA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 7 GLY A 400
SER A 454
THR A 383
ALA A 460
 None
 0.77A 5o96C-1lpfA:
2.0		 5o96C-1lpfA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 ALA A 173
VAL A 208
GLY A 189
ALA A 188
LEU A 236
 None
 1.06A 5xxiA-1lpfA:
0.0		 5xxiA-1lpfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 10 PHE A 436
THR A 438
ASP A 442
GLY A 430
ILE A 432
 None
 1.20A 6ebpB-1lpfA:
undetectable		 6ebpB-1lpfA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 10 PHE A 436
THR A 438
ASP A 442
GLY A 430
ILE A 432
 None
 1.22A 6ebpC-1lpfA:
undetectable		 6ebpC-1lpfA:
11.30