SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lqa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1lqa TAS PROTEIN
(Escherichia
coli) 		5 / 9 ALA A  85
LEU A  82
ARG A  79
ILE A  44
LEU A 306
 None
None
None
None
NDP  A1400 (-4.2A)
 1.01A 1ereA-1lqaA:
undetectable		 1ereA-1lqaA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 1lqa TAS PROTEIN
(Escherichia
coli) 		5 / 9 ALA A  85
LEU A  82
ARG A  79
ILE A  44
LEU A 306
 None
None
None
None
NDP  A1400 (-4.2A)
 1.02A 1ereB-1lqaA:
undetectable		 1ereB-1lqaA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 1lqa TAS PROTEIN
(Escherichia
coli) 		5 / 9 ALA A  85
LEU A  82
ARG A  79
ILE A  44
LEU A 306
 None
None
None
None
NDP  A1400 (-4.2A)
 1.02A 1ereC-1lqaA:
undetectable		 1ereC-1lqaA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 1lqa TAS PROTEIN
(Escherichia
coli) 		5 / 9 ALA A  85
LEU A  82
ARG A  79
ILE A  44
LEU A 306
 None
None
None
None
NDP  A1400 (-4.2A)
 1.01A 1ereD-1lqaA:
undetectable		 1ereD-1lqaA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1lqa TAS PROTEIN
(Escherichia
coli) 		4 / 8 ALA A  85
LEU A  82
ARG A  79
LEU A 306
 None
None
None
NDP  A1400 (-4.2A)
 0.83A 1ereE-1lqaA:
undetectable		 1ereE-1lqaA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 1lqa TAS PROTEIN
(Escherichia
coli) 		4 / 8 ALA A  85
LEU A  82
ARG A  79
LEU A 306
 None
None
None
NDP  A1400 (-4.2A)
 0.86A 1ereF-1lqaA:
undetectable		 1ereF-1lqaA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1lqa TAS PROTEIN
(Escherichia
coli) 		5 / 10 ALA A 276
SER A 209
PHE A 295
ALA A 292
ILE A 280
 None
 1.14A 1g5yC-1lqaA:
undetectable		 1g5yC-1lqaA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 1lqa TAS PROTEIN
(Escherichia
coli) 		5 / 10 ALA A  85
LEU A  82
ARG A  79
ILE A  44
LEU A 306
 None
None
None
None
NDP  A1400 (-4.2A)
 1.06A 1pcgA-1lqaA:
undetectable		 1pcgA-1lqaA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 1lqa TAS PROTEIN
(Escherichia
coli) 		3 / 3 LEU A 307
LEU A  46
MET A   1
 None
 0.82A 1ya3B-1lqaA:
0.0		 1ya3B-1lqaA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1lqa TAS PROTEIN
(Escherichia
coli) 		5 / 12 VAL A 340
ASP A 279
ALA A 276
TYR A 277
ARG A 283
 None
 1.42A 2avdB-1lqaA:
0.0		 2avdB-1lqaA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 1lqa TAS PROTEIN
(Escherichia
coli) 		5 / 9 LEU A 118
GLU A  51
HIS A 132
LEU A 128
LEU A 105
 None
None
NDP  A1400 (-4.4A)
None
None
 1.32A 2azqA-1lqaA:
undetectable		 2azqA-1lqaA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1lqa TAS PROTEIN
(Escherichia
coli) 		5 / 12 PHE A 141
ALA A  85
SER A  86
ALA A  50
GLY A 177
 NDP  A1400 ( 4.8A)
None
None
None
None
 1.08A 2igtA-1lqaA:
undetectable		 2igtA-1lqaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1lqa TAS PROTEIN
(Escherichia
coli) 		5 / 12 PHE A 141
ALA A  85
SER A  86
ALA A  50
GLY A 177
 NDP  A1400 ( 4.8A)
None
None
None
None
 1.07A 2igtB-1lqaA:
undetectable		 2igtB-1lqaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 1lqa TAS PROTEIN
(Escherichia
coli) 		5 / 12 ALA A  85
LEU A  82
ARG A  79
GLY A  17
LEU A 306
 None
None
None
None
NDP  A1400 (-4.2A)
 1.11A 2yjaB-1lqaA:
undetectable		 2yjaB-1lqaA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 1lqa TAS PROTEIN
(Escherichia
coli) 		5 / 12 LEU A  16
GLY A  17
LEU A 307
ILE A 319
ALA A 309
 None
 1.01A 3gwwA-1lqaA:
0.0		 3gwwA-1lqaA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1lqa TAS PROTEIN
(Escherichia
coli) 		5 / 12 ALA A  85
LEU A  82
ARG A  79
GLY A  17
LEU A 306
 None
None
None
None
NDP  A1400 (-4.2A)
 1.03A 3olsA-1lqaA:
undetectable		 3olsA-1lqaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1lqa TAS PROTEIN
(Escherichia
coli) 		5 / 12 TYR A  53
HIS A 132
ASN A 180
TYR A 233
SER A 234
 None
NDP  A1400 (-4.4A)
NDP  A1400 (-3.2A)
NDP  A1400 (-3.2A)
NDP  A1400 (-2.7A)
 0.25A 3ug8A-1lqaA:
29.3		 3ug8A-1lqaA:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 1lqa TAS PROTEIN
(Escherichia
coli) 		4 / 7 PRO A 251
GLY A 253
ALA A 254
ARG A 255
 None
None
NDP  A1400 (-3.6A)
NDP  A1400 (-3.0A)
 0.70A 3ur0B-1lqaA:
0.0		 3ur0B-1lqaA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1lqa TAS PROTEIN
(Escherichia
coli) 		3 / 3 PHE A 184
VAL A 228
ILE A 204
 None
 0.45A 4emaA-1lqaA:
undetectable		 4emaA-1lqaA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 1lqa TAS PROTEIN
(Escherichia
coli) 		4 / 6 GLU A  51
ARG A 120
GLU A  66
SER A  86
 None
 0.96A 4kr3A-1lqaA:
undetectable		 4kr3A-1lqaA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1lqa TAS PROTEIN
(Escherichia
coli) 		4 / 5 HIS A   4
LEU A 307
TYR A 208
PHE A 215
 None
 1.27A 5igjA-1lqaA:
0.0		 5igjA-1lqaA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1lqa TAS PROTEIN
(Escherichia
coli) 		4 / 4 LEU A 306
LEU A 231
SER A  14
ALA A 303
 NDP  A1400 (-4.2A)
None
None
None
 1.05A 5uunA-1lqaA:
0.0		 5uunA-1lqaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 1lqa TAS PROTEIN
(Escherichia
coli) 		5 / 12 PHE A  23
TYR A  53
ALA A  85
LEU A 306
LEU A  18
 None
None
None
NDP  A1400 (-4.2A)
None
 1.23A 6aybA-1lqaA:
undetectable		 6aybA-1lqaA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1lqa TAS PROTEIN
(Escherichia
coli) 		4 / 5 VAL A  49
THR A  20
LEU A 126
LEU A  11
 None
 1.03A 6bqgA-1lqaA:
0.0		 6bqgA-1lqaA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1lqa TAS PROTEIN
(Escherichia
coli) 		5 / 9 GLY A 218
MET A 187
GLY A 185
GLU A 181
THR A 138
 None
 1.49A 6nknG-1lqaA:
0.0
6nknN-1lqaA:
0.0
6nknO-1lqaA:
undetectable		 6nknG-1lqaA:
14.20
6nknN-1lqaA:
20.68
6nknO-1lqaA:
21.66