SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lqk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1LQP_A_FCNA4002_1 (PROBABLE FOSFOMYCIN RESISTANCE PROTEIN)	1lqk	PROBABLE FOSFOMYCIN RESISTANCE PROTEIN (Pseudomonas aeruginosa)	6 / 10	HIS A 64 LYS A 90 SER A 94 TYR A 100 GLU A 110 ARG A 119	MN A 901 ( 3.3A) PO4 A 501 (-2.6A) K A 701 ( 2.6A) PO4 A 501 ( 4.1A) MN A 901 ( 2.6A) PO4 A 501 ( 2.6A)	0.24A	1lqpA-1lqkA: 24.0 1lqpB-1lqkA: 23.9	1lqpA-1lqkA: 100.00 1lqpB-1lqkA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1LQP_B_FCNB4001_1 (PROBABLE FOSFOMYCIN RESISTANCE PROTEIN)	1lqk	PROBABLE FOSFOMYCIN RESISTANCE PROTEIN (Pseudomonas aeruginosa)	6 / 10	HIS A 64 LYS A 90 SER A 94 TYR A 100 GLU A 110 ARG A 119	MN A 901 ( 3.3A) PO4 A 501 (-2.6A) K A 701 ( 2.6A) PO4 A 501 ( 4.1A) MN A 901 ( 2.6A) PO4 A 501 ( 2.6A)	0.23A	1lqpA-1lqkA: 24.0 1lqpB-1lqkA: 23.9	1lqpA-1lqkA: 100.00 1lqpB-1lqkA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1NKI_A_PPFA5001_1 (PROBABLE FOSFOMYCIN RESISTANCE PROTEIN)	1lqk	PROBABLE FOSFOMYCIN RESISTANCE PROTEIN (Pseudomonas aeruginosa)	5 / 9	HIS A 64 SER A 94 TYR A 100 GLU A 110 ARG A 119	MN A 901 ( 3.3A) K A 701 ( 2.6A) PO4 A 501 ( 4.1A) MN A 901 ( 2.6A) PO4 A 501 ( 2.6A)	0.14A	1nkiA-1lqkA: 24.6 1nkiB-1lqkA: 24.2	1nkiA-1lqkA: 100.00 1nkiB-1lqkA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1NKI_B_PPFB5002_1 (PROBABLE FOSFOMYCIN RESISTANCE PROTEIN)	1lqk	PROBABLE FOSFOMYCIN RESISTANCE PROTEIN (Pseudomonas aeruginosa)	5 / 9	HIS A 64 SER A 94 TYR A 100 GLU A 110 ARG A 119	MN A 901 ( 3.3A) K A 701 ( 2.6A) PO4 A 501 ( 4.1A) MN A 901 ( 2.6A) PO4 A 501 ( 2.6A)	0.13A	1nkiA-1lqkA: 24.6 1nkiB-1lqkA: 24.2	1nkiA-1lqkA: 100.00 1nkiB-1lqkA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TSN_A_C2FA266_0 (THYMIDYLATE SYNTHASE)	1lqk	PROBABLE FOSFOMYCIN RESISTANCE PROTEIN (Pseudomonas aeruginosa)	5 / 12	ILE A 19 LEU A 47 GLY A 37 VAL A 12 ALA A 11	None	1.15A	1tsnA-1lqkA: 0.0	1tsnA-1lqkA: 19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q0I_A_BEZA990_0 (QUINOLONE SIGNAL RESPONSE PROTEIN)	1lqk	PROBABLE FOSFOMYCIN RESISTANCE PROTEIN (Pseudomonas aeruginosa)	4 / 8	ASP A 103 LEU A 109 HIS A 107 LEU A 8	None	1.05A	2q0iA-1lqkA: undetectable	2q0iA-1lqkA: 19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VW7_A_VPXA2001_1 (PROTEINASE-ACTIVATED RECEPTOR 1, LYSOZYME)	1lqk	PROBABLE FOSFOMYCIN RESISTANCE PROTEIN (Pseudomonas aeruginosa)	5 / 12	TYR A 22 LEU A 47 PHE A 67 LEU A 102 LEU A 109	None	0.87A	3vw7A-1lqkA: 0.0	3vw7A-1lqkA: 15.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5V3D_A_FCNA205_1 (FOSFOMYCIN RESISTANCE PROTEIN)	1lqk	PROBABLE FOSFOMYCIN RESISTANCE PROTEIN (Pseudomonas aeruginosa)	5 / 10	HIS A 64 SER A 94 TYR A 100 GLU A 110 ARG A 119	MN A 901 ( 3.3A) K A 701 ( 2.6A) PO4 A 501 ( 4.1A) MN A 901 ( 2.6A) PO4 A 501 ( 2.6A)	0.19A	5v3dA-1lqkA: 22.3 5v3dB-1lqkA: 22.2	5v3dA-1lqkA: 65.22 5v3dB-1lqkA: 65.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNE_A_ACRA602_2 (-)	1lqk	PROBABLE FOSFOMYCIN RESISTANCE PROTEIN (Pseudomonas aeruginosa)	4 / 6	TYR A 62 ASN A 92 TYR A 100 GLU A 95	None K A 701 (-3.1A) PO4 A 501 ( 4.1A) None	1.31A	6gneA-1lqkA: undetectable	6gneA-1lqkA: 17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNE_B_ACRB602_2 (-)	1lqk	PROBABLE FOSFOMYCIN RESISTANCE PROTEIN (Pseudomonas aeruginosa)	4 / 8	TYR A 62 ASN A 92 TYR A 100 GLU A 95	None K A 701 (-3.1A) PO4 A 501 ( 4.1A) None	1.32A	6gneB-1lqkA: undetectable	6gneB-1lqkA: 17.48

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1LQP_A_FCNA4002_1","PROBABLE FOSFOMYCIN RESISTANCE PROTEIN;PROBABLE FOSFOMYCIN RESISTANCE PROTEIN","1lqk","PROBABLE FOSFOMYCIN RESISTANCE PROTEIN","Pseudomonas aeruginosa",6,"HIS A  64;LYS A  90;SER A  94;TYR A 100;GLU A 110;ARG A 119"," MN A 901 ( 3.3A);PO4 A 501 (-2.6A);  K A 701 ( 2.6A);PO4 A 501 ( 4.1A); MN A 901 ( 2.6A);PO4 A 501 ( 2.6A)","0.24A","1lqpA-1lqkA:24.0;1lqpB-1lqkA:23.9","1lqpA-1lqkA:100.00;1lqpB-1lqkA:100.00"],["1LQP_B_FCNB4001_1","PROBABLE FOSFOMYCIN RESISTANCE PROTEIN;PROBABLE FOSFOMYCIN RESISTANCE PROTEIN","1lqk","PROBABLE FOSFOMYCIN RESISTANCE PROTEIN","Pseudomonas aeruginosa",6,"HIS A  64;LYS A  90;SER A  94;TYR A 100;GLU A 110;ARG A 119"," MN A 901 ( 3.3A);PO4 A 501 (-2.6A);  K A 701 ( 2.6A);PO4 A 501 ( 4.1A); MN A 901 ( 2.6A);PO4 A 501 ( 2.6A)","0.23A","1lqpA-1lqkA:24.0;1lqpB-1lqkA:23.9","1lqpA-1lqkA:100.00;1lqpB-1lqkA:100.00"],["1NKI_A_PPFA5001_1","PROBABLE FOSFOMYCIN RESISTANCE PROTEIN;PROBABLE FOSFOMYCIN RESISTANCE PROTEIN","1lqk","PROBABLE FOSFOMYCIN RESISTANCE PROTEIN","Pseudomonas aeruginosa",5,"HIS A  64;SER A  94;TYR A 100;GLU A 110;ARG A 119"," MN A 901 ( 3.3A);  K A 701 ( 2.6A);PO4 A 501 ( 4.1A); MN A 901 ( 2.6A);PO4 A 501 ( 2.6A)","0.14A","1nkiA-1lqkA:24.6;1nkiB-1lqkA:24.2","1nkiA-1lqkA:100.00;1nkiB-1lqkA:100.00"],["1NKI_B_PPFB5002_1","PROBABLE FOSFOMYCIN RESISTANCE PROTEIN;PROBABLE FOSFOMYCIN RESISTANCE PROTEIN","1lqk","PROBABLE FOSFOMYCIN RESISTANCE PROTEIN","Pseudomonas aeruginosa",5,"HIS A  64;SER A  94;TYR A 100;GLU A 110;ARG A 119"," MN A 901 ( 3.3A);  K A 701 ( 2.6A);PO4 A 501 ( 4.1A); MN A 901 ( 2.6A);PO4 A 501 ( 2.6A)","0.13A","1nkiA-1lqkA:24.6;1nkiB-1lqkA:24.2","1nkiA-1lqkA:100.00;1nkiB-1lqkA:100.00"],["1TSN_A_C2FA266_0","THYMIDYLATE SYNTHASE","1lqk","PROBABLE FOSFOMYCIN RESISTANCE PROTEIN","Pseudomonas aeruginosa",5,"ILE A  19;LEU A  47;GLY A  37;VAL A  12;ALA A  11","None","1.15A","1tsnA-1lqkA:0.0","1tsnA-1lqkA:19.48"],["2Q0I_A_BEZA990_0","QUINOLONE SIGNAL RESPONSE PROTEIN","1lqk","PROBABLE FOSFOMYCIN RESISTANCE PROTEIN","Pseudomonas aeruginosa",4,"ASP A 103;LEU A 109;HIS A 107;LEU A   8","None","1.05A","2q0iA-1lqkA:undetectable","2q0iA-1lqkA:19.37"],["3VW7_A_VPXA2001_1","PROTEINASE-ACTIVATED RECEPTOR 1, LYSOZYME","1lqk","PROBABLE FOSFOMYCIN RESISTANCE PROTEIN","Pseudomonas aeruginosa",5,"TYR A  22;LEU A  47;PHE A  67;LEU A 102;LEU A 109","None","0.87A","3vw7A-1lqkA:0.0","3vw7A-1lqkA:15.32"],["5V3D_A_FCNA205_1","FOSFOMYCIN RESISTANCE PROTEIN;FOSFOMYCIN RESISTANCE PROTEIN","1lqk","PROBABLE FOSFOMYCIN RESISTANCE PROTEIN","Pseudomonas aeruginosa",5,"HIS A  64;SER A  94;TYR A 100;GLU A 110;ARG A 119"," MN A 901 ( 3.3A);  K A 701 ( 2.6A);PO4 A 501 ( 4.1A); MN A 901 ( 2.6A);PO4 A 501 ( 2.6A)","0.19A","5v3dA-1lqkA:22.3;5v3dB-1lqkA:22.2","5v3dA-1lqkA:65.22;5v3dB-1lqkA:65.22"],["6GNE_A_ACRA602_2","-","1lqk","PROBABLE FOSFOMYCIN RESISTANCE PROTEIN","Pseudomonas aeruginosa",4,"TYR A  62;ASN A  92;TYR A 100;GLU A  95","None;  K A 701 (-3.1A);PO4 A 501 ( 4.1A);None","1.31A","6gneA-1lqkA:undetectable","6gneA-1lqkA:17.48"],["6GNE_B_ACRB602_2","-","1lqk","PROBABLE FOSFOMYCIN RESISTANCE PROTEIN","Pseudomonas aeruginosa",4,"TYR A  62;ASN A  92;TYR A 100;GLU A  95","None;  K A 701 (-3.1A);PO4 A 501 ( 4.1A);None","1.32A","6gneB-1lqkA:undetectable","6gneB-1lqkA:17.48"]]