SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lqt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		5 / 9 ILE A   8
LEU A 386
VAL A 379
ALA A  18
LEU A  22
 None
 1.01A 1e7bA-1lqtA:
undetectable		 1e7bA-1lqtA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 317
ALA A 150
VAL A 194
TYR A 132
 None
 0.73A 1epbA-1lqtA:
undetectable		 1epbA-1lqtA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		5 / 9 ALA A  15
GLY A 358
ILE A 360
VAL A 100
ILE A   8
 None
FAD  A2457 (-2.6A)
None
None
None
 1.13A 1hpvB-1lqtA:
undetectable		 1hpvB-1lqtA:
14.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQT_A_ACTA1866_0
(FPRA)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 4 ARG A 110
LEU A 112
ASN A 113
VAL A 322
 ACT  A1866 ( 2.5A)
ACT  A1866 (-4.1A)
ACT  A1866 (-4.4A)
ODP  A2458 ( 3.8A)
 0.00A 1lqtA-1lqtA:
66.0		 1lqtA-1lqtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQT_A_ACTA1869_0
(FPRA)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 4 ASP A  56
HIS A  57
ARG A 164
GLU A 214
 ACT  A1869 (-3.7A)
ACT  A1869 (-3.7A)
None
ACT  A1869 (-2.6A)
 0.01A 1lqtA-1lqtA:
66.0		 1lqtA-1lqtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQT_A_ACTA1870_0
(FPRA)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 4 HIS A  57
PRO A  58
LYS A  59
ILE A  60
 ACT  A1869 (-3.7A)
ACT  A1870 (-3.3A)
ACT  A1870 (-4.8A)
FAD  A2457 ( 3.5A)
 0.31A 1lqtA-1lqtA:
66.0		 1lqtA-1lqtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQT_A_ACTA1871_0
(FPRA)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		7 / 7 PHE A  16
PRO A  45
ALA A  71
PHE A  76
PHE A  78
SER A 420
TRP A 423
 ACT  A1871 ( 4.6A)
ACT  A1871 ( 4.1A)
ACT  A1871 (-3.3A)
ACT  A1871 ( 4.6A)
ACT  A1871 (-3.0A)
ACT  A1871 (-2.7A)
None
 0.01A 1lqtA-1lqtA:
66.0		 1lqtA-1lqtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQT_A_ACTA1872_0
(FPRA)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 5 SER A 274
ASN A 292
ALA A 304
ASP A 306
 ACT  A1872 ( 3.1A)
ACT  A1872 (-2.2A)
ACT  A1872 (-2.5A)
None
 0.00A 1lqtA-1lqtA:
66.0
1lqtB-1lqtA:
62.8		 1lqtA-1lqtA:
100.00
1lqtB-1lqtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQT_B_ACTB1867_0
(FPRA)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 4 ALA A 148
ARG A 149
GLN A 192
GLU A 193
 None
 0.18A 1lqtB-1lqtA:
62.8		 1lqtB-1lqtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQT_B_ACTB1874_0
(FPRA)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		5 / 5 TRP A  46
ALA A  71
PHE A  78
SER A 420
TRP A 423
 None
ACT  A1871 (-3.3A)
ACT  A1871 (-3.0A)
ACT  A1871 (-2.7A)
None
 0.15A 1lqtB-1lqtA:
62.8		 1lqtB-1lqtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQT_B_ACTB1875_0
(FPRA)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 4 ARG A 110
LEU A 112
ASN A 113
VAL A 322
 ACT  A1866 ( 2.5A)
ACT  A1866 (-4.1A)
ACT  A1866 (-4.4A)
ODP  A2458 ( 3.8A)
 0.05A 1lqtB-1lqtA:
62.8		 1lqtB-1lqtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQU_A_ACTA1423_0
(FPRA)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 4 ARG A 110
LEU A 112
ASN A 113
VAL A 322
 ACT  A1866 ( 2.5A)
ACT  A1866 (-4.1A)
ACT  A1866 (-4.4A)
ODP  A2458 ( 3.8A)
 0.03A 1lquA-1lqtA:
64.3		 1lquA-1lqtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQU_A_ACTA1426_0
(FPRA)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 4 ASP A  56
HIS A  57
ARG A 164
GLU A 214
 ACT  A1869 (-3.7A)
ACT  A1869 (-3.7A)
None
ACT  A1869 (-2.6A)
 0.54A 1lquA-1lqtA:
64.3		 1lquA-1lqtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQU_A_ACTA1428_0
(FPRA)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		7 / 7 PHE A  16
PRO A  45
ALA A  71
PHE A  76
PHE A  78
SER A 420
TRP A 423
 ACT  A1871 ( 4.6A)
ACT  A1871 ( 4.1A)
ACT  A1871 (-3.3A)
ACT  A1871 ( 4.6A)
ACT  A1871 (-3.0A)
ACT  A1871 (-2.7A)
None
 0.04A 1lquA-1lqtA:
64.3		 1lquA-1lqtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQU_A_ACTA1429_0
(FPRA)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 5 SER A 274
ASN A 292
ALA A 304
ASP A 306
 ACT  A1872 ( 3.1A)
ACT  A1872 (-2.2A)
ACT  A1872 (-2.5A)
None
 0.04A 1lquA-1lqtA:
64.3
1lquB-1lqtA:
62.7		 1lquA-1lqtA:
100.00
1lquB-1lqtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQU_B_ACTB1424_0
(FPRA)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 4 ALA A 148
ARG A 149
GLN A 192
GLU A 193
 None
 0.19A 1lquB-1lqtA:
62.7		 1lquB-1lqtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQU_B_ACTB1431_0
(FPRA)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		5 / 5 TRP A  46
ALA A  71
PHE A  78
SER A 420
TRP A 423
 None
ACT  A1871 (-3.3A)
ACT  A1871 (-3.0A)
ACT  A1871 (-2.7A)
None
 0.13A 1lquB-1lqtA:
62.7		 1lquB-1lqtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQU_B_ACTB1432_0
(FPRA)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 4 ARG A 110
LEU A 112
ASN A 113
VAL A 322
 ACT  A1866 ( 2.5A)
ACT  A1866 (-4.1A)
ACT  A1866 (-4.4A)
ODP  A2458 ( 3.8A)
 0.07A 1lquB-1lqtA:
62.7		 1lquB-1lqtA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 129
TYR A 132
ASP A  56
LEU A  48
 FAD  A2457 ( 4.3A)
None
ACT  A1869 (-3.7A)
FAD  A2457 (-2.9A)
 1.18A 1pk2A-1lqtA:
undetectable		 1pk2A-1lqtA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 7 MET A  38
ALA A  15
PHE A  78
ARG A  50
 ACT  A1871 ( 4.7A)
None
ACT  A1871 (-3.0A)
None
 0.97A 1t9wA-1lqtA:
undetectable		 1t9wA-1lqtA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 6 PRO A  45
GLY A  12
ILE A   8
GLY A  10
 ACT  A1871 ( 4.1A)
FAD  A2457 (-3.6A)
None
FAD  A2457 (-3.2A)
 0.84A 1usqB-1lqtA:
undetectable		 1usqB-1lqtA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 6 PRO A  45
GLY A  12
ILE A   8
GLY A  10
 ACT  A1871 ( 4.1A)
FAD  A2457 (-3.6A)
None
FAD  A2457 (-3.2A)
 0.83A 1usqD-1lqtA:
undetectable		 1usqD-1lqtA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 6 PRO A  45
GLY A  12
ILE A   8
GLY A  10
 ACT  A1871 ( 4.1A)
FAD  A2457 (-3.6A)
None
FAD  A2457 (-3.2A)
 0.82A 1usqE-1lqtA:
undetectable		 1usqE-1lqtA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 7 PRO A  45
GLY A  12
ILE A   8
GLY A  10
 ACT  A1871 ( 4.1A)
FAD  A2457 (-3.6A)
None
FAD  A2457 (-3.2A)
 0.83A 1usqF-1lqtA:
undetectable		 1usqF-1lqtA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		5 / 8 GLY A  12
GLY A  10
SER A  14
ALA A  15
ILE A 360
 FAD  A2457 (-3.6A)
FAD  A2457 (-3.2A)
FAD  A2457 (-2.7A)
None
None
 0.93A 1yajC-1lqtA:
undetectable		 1yajC-1lqtA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 118
ILE A 287
VAL A 322
 None
None
ODP  A2458 ( 3.8A)
 0.66A 2avvD-1lqtA:
undetectable		 2avvD-1lqtA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		5 / 11 ARG A  96
TYR A  97
VAL A  84
GLY A  85
LEU A  39
 None
None
FAD  A2457 (-3.6A)
FAD  A2457 ( 4.7A)
None
 1.25A 2bxeA-1lqtA:
undetectable		 2bxeA-1lqtA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 6 PRO A  45
GLY A  12
ILE A   8
GLY A  10
 ACT  A1871 ( 4.1A)
FAD  A2457 (-3.6A)
None
FAD  A2457 (-3.2A)
 0.79A 2jkjA-1lqtA:
undetectable		 2jkjA-1lqtA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 6 PRO A  45
GLY A  12
ILE A   8
GLY A  10
 ACT  A1871 ( 4.1A)
FAD  A2457 (-3.6A)
None
FAD  A2457 (-3.2A)
 0.79A 2jkjB-1lqtA:
undetectable		 2jkjB-1lqtA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 6 PRO A  45
GLY A  12
ILE A   8
GLY A  10
 ACT  A1871 ( 4.1A)
FAD  A2457 (-3.6A)
None
FAD  A2457 (-3.2A)
 0.80A 2jkjC-1lqtA:
undetectable		 2jkjC-1lqtA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 7 PRO A  45
GLY A  12
ILE A   8
GLY A  10
 ACT  A1871 ( 4.1A)
FAD  A2457 (-3.6A)
None
FAD  A2457 (-3.2A)
 0.78A 2jkjE-1lqtA:
undetectable		 2jkjE-1lqtA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 7 PRO A  45
GLY A  12
ILE A   8
GLY A  10
 ACT  A1871 ( 4.1A)
FAD  A2457 (-3.6A)
None
FAD  A2457 (-3.2A)
 0.83A 2jklA-1lqtA:
undetectable		 2jklA-1lqtA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 6 PRO A  45
GLY A  12
ILE A   8
GLY A  10
 ACT  A1871 ( 4.1A)
FAD  A2457 (-3.6A)
None
FAD  A2457 (-3.2A)
 0.83A 2jklB-1lqtA:
undetectable		 2jklB-1lqtA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 7 PRO A  45
GLY A  12
ILE A   8
GLY A  10
 ACT  A1871 ( 4.1A)
FAD  A2457 (-3.6A)
None
FAD  A2457 (-3.2A)
 0.86A 2jklC-1lqtA:
undetectable		 2jklC-1lqtA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 7 PRO A  45
GLY A  12
ILE A   8
GLY A  10
 ACT  A1871 ( 4.1A)
FAD  A2457 (-3.6A)
None
FAD  A2457 (-3.2A)
 0.83A 2jklD-1lqtA:
undetectable		 2jklD-1lqtA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 7 PRO A  45
GLY A  12
ILE A   8
GLY A  10
 ACT  A1871 ( 4.1A)
FAD  A2457 (-3.6A)
None
FAD  A2457 (-3.2A)
 0.83A 2jklE-1lqtA:
undetectable		 2jklE-1lqtA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 7 PRO A  45
GLY A  12
ILE A   8
GLY A  10
 ACT  A1871 ( 4.1A)
FAD  A2457 (-3.6A)
None
FAD  A2457 (-3.2A)
 0.83A 2jklF-1lqtA:
undetectable		 2jklF-1lqtA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 403
ASP A  37
TYR A  97
HIS A 402
 None
 1.32A 2pncB-1lqtA:
0.0		 2pncB-1lqtA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 7 PHE A 128
TYR A 132
THR A 168
VAL A 194
 None
 1.00A 2qblA-1lqtA:
0.0		 2qblA-1lqtA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 128
TYR A 132
THR A 168
VAL A 194
 None
 0.98A 2qbmA-1lqtA:
0.0		 2qbmA-1lqtA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 450
ILE A 426
GLY A 454
GLY A 456
SER A 446
 None
 1.17A 2qmmA-1lqtA:
3.8		 2qmmA-1lqtA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 442
THR A  44
THR A 176
ARG A 439
 None
 0.86A 3bjwG-1lqtA:
0.0		 3bjwG-1lqtA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 5 ALA A 103
ALA A  99
TYR A  97
MET A  34
 FAD  A2457 (-4.9A)
None
None
None
 1.28A 3d91A-1lqtA:
0.0		 3d91A-1lqtA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 132
ASP A 177
HIS A  57
 None
None
ACT  A1869 (-3.7A)
 0.91A 3e23A-1lqtA:
undetectable		 3e23A-1lqtA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 450
ALA A 428
GLY A  80
PRO A  43
 None
 0.89A 3ny4A-1lqtA:
undetectable		 3ny4A-1lqtA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 375
PHE A  76
ALA A  20
THR A  70
 None
ACT  A1871 ( 4.6A)
None
None
 0.97A 3t3sE-1lqtA:
0.0		 3t3sE-1lqtA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 225
LEU A 230
ILE A 249
ILE A 196
LEU A 212
 None
 1.04A 3vrmA-1lqtA:
0.0		 3vrmA-1lqtA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		5 / 8 ILE A 348
ILE A 341
PHE A 334
VAL A 104
GLY A 326
 None
None
None
FAD  A2457 (-3.8A)
None
 1.46A 4ac9C-1lqtA:
undetectable		 4ac9C-1lqtA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 223
ALA A 256
PHE A 271
PHE A 269
LEU A 160
 None
 1.09A 4eckA-1lqtA:
undetectable		 4eckA-1lqtA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 160
VAL A 223
VAL A 194
LEU A 212
 None
 0.90A 4puoC-1lqtA:
undetectable		 4puoC-1lqtA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		3 / 3 MET A 111
ASP A 127
PHE A 128
 None
 0.90A 4xeyA-1lqtA:
0.0		 4xeyA-1lqtA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		3 / 3 MET A 111
ASP A 127
PHE A 128
 None
 0.88A 4xeyB-1lqtA:
0.0		 4xeyB-1lqtA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 327
ILE A 360
HIS A 135
LEU A  42
 None
None
None
FAD  A2457 ( 4.3A)
 1.24A 4xo7B-1lqtA:
undetectable		 4xo7B-1lqtA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 4 LEU A  48
ILE A 368
GLY A  52
ILE A  60
 FAD  A2457 (-2.9A)
FAD  A2457 (-3.7A)
FAD  A2457 (-3.0A)
FAD  A2457 ( 3.5A)
 0.84A 5dzk3-1lqtA:
undetectable
5dzkm-1lqtA:
0.0		 5dzk3-1lqtA:
8.70
5dzkm-1lqtA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 368
GLY A  52
ILE A  60
LEU A  48
 FAD  A2457 (-3.7A)
FAD  A2457 (-3.0A)
FAD  A2457 ( 3.5A)
FAD  A2457 (-2.9A)
 0.74A 5dzkB-1lqtA:
undetectable
5dzkI-1lqtA:
undetectable
5dzkW-1lqtA:
undetectable		 5dzkB-1lqtA:
19.65
5dzkI-1lqtA:
19.09
5dzkW-1lqtA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 368
GLY A  52
ILE A  60
LEU A  48
 FAD  A2457 (-3.7A)
FAD  A2457 (-3.0A)
FAD  A2457 ( 3.5A)
FAD  A2457 (-2.9A)
 0.78A 5dzki-1lqtA:
undetectable
5dzkj-1lqtA:
undetectable
5dzkx-1lqtA:
undetectable		 5dzki-1lqtA:
19.09
5dzkj-1lqtA:
19.09
5dzkx-1lqtA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 4 ILE A 368
GLY A  52
ILE A  60
LEU A  48
 FAD  A2457 (-3.7A)
FAD  A2457 (-3.0A)
FAD  A2457 ( 3.5A)
FAD  A2457 (-2.9A)
 0.68A 5dzkl-1lqtA:
0.0
5dzkz-1lqtA:
undetectable		 5dzkl-1lqtA:
19.09
5dzkz-1lqtA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		5 / 12 ILE A   8
GLY A 363
PRO A 364
TYR A 355
LEU A  22
 None
 1.21A 5ienA-1lqtA:
0.0		 5ienA-1lqtA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		5 / 12 ARG A 320
PRO A 275
LEU A 112
GLY A 198
GLY A 154
 None
None
ACT  A1866 (-4.1A)
None
ODP  A2458 ( 3.4A)
 1.17A 5l6eA-1lqtA:
undetectable		 5l6eA-1lqtA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 177
GLU A 430
ALA A 445
GLN A 107
LEU A  42
 None
None
None
FAD  A2457 ( 2.8A)
FAD  A2457 ( 4.3A)
 1.06A 5m5cB-1lqtA:
undetectable		 5m5cB-1lqtA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  32
TYR A   4
VAL A   9
GLY A 387
 None
None
FAD  A2457 ( 4.7A)
None
 0.96A 6hd4B-1lqtA:
undetectable		 6hd4B-1lqtA:
10.18