SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 1lqw PEPTIDE DEFORMYLASE
PDF1
(Staphylococcus
aureus) 		5 / 12 MET A  37
LEU A  61
GLY A  60
VAL A 151
LEU A 159
 None
 1.38A 1nhzA-1lqwA:
undetectable		 1nhzA-1lqwA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1lqw PEPTIDE DEFORMYLASE
PDF1
(Staphylococcus
aureus) 		5 / 10 ILE A  95
ALA A 149
LEU A 142
ILE A  73
ILE A 156
 None
 1.24A 1rb3A-1lqwA:
undetectable		 1rb3A-1lqwA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 1lqw PEPTIDE DEFORMYLASE
PDF1
(Staphylococcus
aureus) 		4 / 8 VAL A  75
VAL A 151
LEU A  76
PRO A  78
 None
 1.04A 2ddwA-1lqwA:
undetectable		 2ddwA-1lqwA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1lqw PEPTIDE DEFORMYLASE
PDF1
(Staphylococcus
aureus) 		3 / 3 HIS A 154
ILE A  73
LEU A  41
 ZN  A 202 (-3.7A)
None
None
 0.70A 2kceA-1lqwA:
undetectable		 2kceA-1lqwA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 1lqw PEPTIDE DEFORMYLASE
PDF1
(Staphylococcus
aureus) 		4 / 8 LEU A 105
PRO A  78
VAL A  75
GLY A  60
 None
 0.95A 2qd5A-1lqwA:
undetectable		 2qd5A-1lqwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1lqw PEPTIDE DEFORMYLASE
PDF1
(Staphylococcus
aureus) 		4 / 6 ILE A  66
ILE A 156
LEU A   2
PHE A  40
 None
 1.19A 3adsA-1lqwA:
undetectable		 3adsA-1lqwA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 1lqw PEPTIDE DEFORMYLASE
PDF1
(Staphylococcus
aureus) 		5 / 12 MET A  37
LEU A  61
GLY A  60
VAL A 151
LEU A 159
 None
 1.33A 3h52A-1lqwA:
undetectable		 3h52A-1lqwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 1lqw PEPTIDE DEFORMYLASE
PDF1
(Staphylococcus
aureus) 		3 / 3 HIS A 154
GLU A 155
HIS A 158
 ZN  A 202 (-3.7A)
None
ZN  A 202 (-3.7A)
 0.18A 3kecB-1lqwA:
undetectable		 3kecB-1lqwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1lqw PEPTIDE DEFORMYLASE
PDF1
(Staphylococcus
aureus) 		5 / 12 ILE A  95
ALA A 149
LEU A 142
ILE A  73
ILE A 156
 None
 1.23A 3ql3A-1lqwA:
undetectable		 3ql3A-1lqwA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1lqw PEPTIDE DEFORMYLASE
PDF1
(Staphylococcus
aureus) 		4 / 5 LEU A  41
HIS A 154
GLU A 155
HIS A 158
 None
ZN  A 202 (-3.7A)
None
ZN  A 202 (-3.7A)
 0.90A 4a7bB-1lqwA:
undetectable		 4a7bB-1lqwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1lqw PEPTIDE DEFORMYLASE
PDF1
(Staphylococcus
aureus) 		3 / 3 HIS A 158
HIS A 154
ARG A 124
 ZN  A 202 (-3.7A)
ZN  A 202 (-3.7A)
None
 1.14A 6b58A-1lqwA:
undetectable		 6b58A-1lqwA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lqw PEPTIDE DEFORMYLASE
PDF1
(Staphylococcus
aureus) 		4 / 8 ILE A 135
ALA A  74
VAL A  75
ARG A  38
 None
 0.98A 6hu9a-1lqwA:
undetectable
6hu9e-1lqwA:
undetectable		 6hu9a-1lqwA:
16.10
6hu9e-1lqwA:
16.94