SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lqy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 1lqy PEPTIDE DEFORMYLASE
2
(Geobacillus
stearothermophil
us) 		4 / 4 LEU A  37
SER A  36
TYR A  40
LEU A  61
 None
 1.21A 1xz1A-1lqyA:
undetectable		 1xz1A-1lqyA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 1lqy PEPTIDE DEFORMYLASE
2
(Geobacillus
stearothermophil
us) 		4 / 4 LEU A  37
SER A  36
TYR A  40
LEU A  61
 None
 1.21A 1xz3A-1lqyA:
undetectable		 1xz3A-1lqyA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1lqy PEPTIDE DEFORMYLASE
2
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A 149
VAL A 121
TYR A 124
CYH A 102
 BB2  A 401 ( 4.9A)
None
None
None
 1.34A 2xz5D-1lqyA:
undetectable
2xz5E-1lqyA:
undetectable		 2xz5D-1lqyA:
22.22
2xz5E-1lqyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 1lqy PEPTIDE DEFORMYLASE
2
(Geobacillus
stearothermophil
us) 		4 / 7 PRO A 176
GLY A 178
ALA A 179
ALA A 125
 None
 0.83A 3ur0B-1lqyA:
0.0		 3ur0B-1lqyA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 1lqy PEPTIDE DEFORMYLASE
2
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  60
ALA A  74
ARG A 123
GLU A 108
HIS A 157
 BB2  A 401 (-4.4A)
None
None
BB2  A 401 ( 3.9A)
NI  A 301 ( 3.4A)
 1.15A 4azsA-1lqyA:
undetectable		 4azsA-1lqyA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1lqy PEPTIDE DEFORMYLASE
2
(Geobacillus
stearothermophil
us) 		3 / 3 ILE A 127
VAL A 129
PRO A  92
 None
 0.71A 5uunA-1lqyA:
undetectable		 5uunA-1lqyA:
18.77