SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lrk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		5 / 10 LEU A  21
ALA A 173
VAL A  27
MET A 247
PHE A  80
 None
 1.42A 1aqbA-1lrkA:
0.0		 1aqbA-1lrkA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		5 / 10 GLY A   8
LEU A  41
VAL A  40
ALA A  81
ASN A  32
 None
None
None
NAD  A 340 (-3.7A)
NAD  A 340 (-3.2A)
 1.41A 1fpqA-1lrkA:
6.0		 1fpqA-1lrkA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		4 / 5 LEU A 215
VAL A 284
ALA A 279
CYH A 280
 None
 1.12A 1mz9D-1lrkA:
0.0		 1mz9D-1lrkA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		5 / 12 ILE A  12
GLY A   8
ILE A  78
SER A  36
GLU A 191
 NAD  A 340 (-3.9A)
None
None
NAD  A 340 (-2.7A)
None
 1.23A 1sg9A-1lrkA:
5.8		 1sg9A-1lrkA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		6 / 12 ILE A  12
GLY A  13
GLY A   8
ILE A  78
SER A  36
GLU A 191
 NAD  A 340 (-3.9A)
None
None
None
NAD  A 340 (-2.7A)
None
 1.32A 1sg9B-1lrkA:
5.9		 1sg9B-1lrkA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		4 / 4 SER A 171
ILE A 172
VAL A  77
THR A  16
 None
 0.96A 1u70A-1lrkA:
0.8		 1u70A-1lrkA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		5 / 12 GLY A   7
GLY A  10
HIS A  15
THR A  16
ASP A  31
 NAD  A 340 (-3.5A)
NAD  A 340 (-3.3A)
None
None
NAD  A 340 (-2.7A)
 0.92A 2gluA-1lrkA:
undetectable		 2gluA-1lrkA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		5 / 12 TYR A 128
ALA A 125
ALA A 298
PRO A 135
GLY A 266
 None
 1.20A 2igtC-1lrkA:
6.8		 2igtC-1lrkA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		4 / 7 GLY A  10
ASP A  31
ASP A  58
ARG A  60
 NAD  A 340 (-3.3A)
NAD  A 340 (-2.7A)
NAD  A 340 (-3.0A)
NAD  A 340 ( 4.7A)
 0.85A 2uyqA-1lrkA:
4.8		 2uyqA-1lrkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		5 / 12 LEU A 175
LEU A 174
ALA A 173
VAL A   3
THR A  76
 None
 1.18A 3cwkA-1lrkA:
undetectable		 3cwkA-1lrkA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		5 / 12 GLY A   7
GLY A  10
THR A  16
ASP A  58
ILE A  59
 NAD  A 340 (-3.5A)
NAD  A 340 (-3.3A)
None
NAD  A 340 (-3.0A)
NAD  A 340 (-3.9A)
 1.01A 3ihtA-1lrkA:
4.8		 3ihtA-1lrkA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		5 / 12 LEU A 175
SER A 123
SER A 171
ILE A 172
THR A  16
 None
 0.99A 4ky8A-1lrkA:
undetectable		 4ky8A-1lrkA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		5 / 12 LEU A 175
SER A 123
SER A 171
ILE A 172
THR A  16
 None
 1.01A 4ky8B-1lrkA:
undetectable		 4ky8B-1lrkA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		5 / 12 LEU A 175
SER A 123
SER A 171
ILE A 172
THR A  16
 None
 0.98A 4ky8D-1lrkA:
undetectable		 4ky8D-1lrkA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		5 / 12 LEU A 175
SER A 123
SER A 171
ILE A 172
THR A  16
 None
 0.98A 4ky8E-1lrkA:
undetectable		 4ky8E-1lrkA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		5 / 11 GLY A   7
GLY A   8
THR A  16
ASP A  31
ASP A  58
 NAD  A 340 (-3.5A)
None
None
NAD  A 340 (-2.7A)
NAD  A 340 (-3.0A)
 0.82A 4pghA-1lrkA:
6.0		 4pghA-1lrkA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		4 / 4 ILE A 120
ASN A 118
ILE A  74
VAL A   3
 None
 1.31A 4uy87-1lrkA:
undetectable		 4uy87-1lrkA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		4 / 6 ARG A 231
ASP A 130
GLY A 294
ASP A 295
 UD1  A 341 (-4.0A)
None
None
UD1  A 341 (-3.5A)
 1.13A 5hp1A-1lrkA:
undetectable		 5hp1A-1lrkA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		5 / 8 VAL A 273
ILE A 217
ALA A 216
VAL A 207
PHE A 276
 None
UD1  A 341 (-4.5A)
None
None
None
 1.34A 5l94A-1lrkA:
undetectable		 5l94A-1lrkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		4 / 5 PRO A 223
GLY A 227
TYR A 222
VAL A 230
 None
 1.30A 5x80C-1lrkA:
0.0
5x80D-1lrkA:
0.0		 5x80C-1lrkA:
20.12
5x80D-1lrkA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		3 / 3 ALA A 125
VAL A  86
TYR A 149
 None
UD1  A 341 (-4.3A)
NAD  A 340 (-4.6A)
 0.63A 5zmqH-1lrkA:
undetectable		 5zmqH-1lrkA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1lrk UDP-GLUCOSE
4-EPIMERASE
(Escherichia
coli) 		4 / 5 VAL A  55
THR A  53
LEU A  64
LEU A 107
 None
 0.99A 6bqgA-1lrkA:
undetectable		 6bqgA-1lrkA:
13.71