SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lrr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 149
PRO A 137
THR A 135
 None
 0.83A 1a7yB-1lrrA:
undetectable		 1a7yB-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 149
PRO A 137
THR A 135
 None
 0.91A 1dscC-1lrrA:
undetectable		 1dscC-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 135
THR A 149
PRO A 137
 None
 0.76A 1dscC-1lrrA:
undetectable		 1dscC-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 135
THR A 149
PRO A 137
 None
 0.81A 1fjaC-1lrrA:
undetectable		 1fjaC-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 135
THR A 149
PRO A 137
 None
 0.81A 1fjaD-1lrrA:
undetectable		 1fjaD-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 135
THR A 149
PRO A 137
 None
 0.86A 1i3wE-1lrrA:
undetectable		 1i3wE-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 135
THR A 149
PRO A 137
 None
 0.83A 1i3wG-1lrrA:
undetectable		 1i3wG-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 135
THR A 149
PRO A 137
 None
 0.84A 1i3wH-1lrrA:
undetectable		 1i3wH-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 135
THR A 149
PRO A 137
 None
 0.83A 1mnvD-1lrrA:
undetectable		 1mnvD-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 149
PRO A 137
THR A 135
 None
 0.84A 1unjL-1lrrA:
undetectable		 1unjL-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 135
THR A 149
PRO A 137
 None
 0.84A 1unjL-1lrrA:
undetectable		 1unjL-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 149
PRO A 137
THR A 135
 None
 0.85A 1unjR-1lrrA:
undetectable		 1unjR-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 135
THR A 149
PRO A 137
 None
 0.83A 1unjR-1lrrA:
undetectable		 1unjR-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 135
THR A 149
PRO A 137
 None
 0.83A 1unjW-1lrrA:
undetectable		 1unjW-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 149
PRO A 137
THR A 135
 None
 0.82A 1unjX-1lrrA:
undetectable		 1unjX-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 135
THR A 149
PRO A 137
 None
 0.85A 1unjX-1lrrA:
undetectable		 1unjX-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 149
PRO A 137
THR A 135
 None
 0.83A 1unmE-1lrrA:
undetectable		 1unmE-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 135
THR A 149
PRO A 137
 None
 0.82A 1unmE-1lrrA:
undetectable		 1unmE-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 149
PRO A 137
THR A 135
 None
 0.85A 1unmF-1lrrA:
undetectable		 1unmF-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 135
THR A 149
PRO A 137
 None
 0.80A 1unmF-1lrrA:
undetectable		 1unmF-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 135
THR A 149
PRO A 137
 None
 0.82A 209dC-1lrrA:
undetectable		 209dC-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 149
PRO A 137
THR A 135
 None
 0.86A 316dC-1lrrA:
undetectable		 316dC-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		3 / 3 THR A 149
PRO A 137
THR A 135
 None
 0.87A 4hivD-1lrrA:
undetectable		 4hivD-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		4 / 6 LEU A  76
TYR A  81
ILE A 160
THR A  97
 None
 1.00A 4l39A-1lrrA:
undetectable		 4l39A-1lrrA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		5 / 9 THR A 180
LEU A  94
GLN A 168
LEU A 173
LEU A  76
 None
 1.42A 5fhzB-1lrrA:
undetectable		 5fhzB-1lrrA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 1lrr SEQA PROTEIN
(Escherichia
coli) 		5 / 12 PRO A 170
ILE A 160
LEU A 173
LEU A 113
THR A 110
 None
 1.20A 5tiwB-1lrrA:
undetectable		 5tiwB-1lrrA:
17.65