SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lrt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 9 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
 None
TAD  A 901 (-2.3A)
None
None
None
 0.95A 1hxwA-1lrtA:
undetectable		 1hxwA-1lrtA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		6 / 11 ASP A 261
SER A 262
SER A 263
ASN A 291
GLY A 314
GLY A 409
 TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-3.9A)
IMP  A 801 ( 3.2A)
 0.82A 1jr1A-1lrtA:
46.0		 1jr1A-1lrtA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 8 ASP A 261
SER A 263
ASN A 291
GLY A 314
GLY A 409
 TAD  A 901 (-2.3A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-3.9A)
IMP  A 801 ( 3.2A)
 0.37A 1jr1B-1lrtA:
45.9		 1jr1B-1lrtA:
26.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		7 / 8 ASP A 261
SER A 262
SER A 263
ASN A 291
ILE A 313
GLY A 314
GLY A 409
 TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
IMP  A 801 ( 3.2A)
 0.33A 1me7A-1lrtA:
57.8		 1me7A-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		6 / 8 SER A 262
SER A 263
ILE A 313
GLY A 314
CYH A 319
GLY A 409
 TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
IMP  A 801 (-4.0A)
IMP  A 801 ( 3.2A)
 0.60A 1me7A-1lrtA:
57.8		 1me7A-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 10 ASP A 261
ASN A 291
GLY A 315
GLU A 408
GLY A 407
 TAD  A 901 (-2.3A)
IMP  A 801 ( 4.6A)
None
None
IMP  A 801 (-3.2A)
 1.17A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		6 / 10 ASP A 261
ASN A 291
GLY A 316
GLU A 408
GLY A 409
ARG A 414
 TAD  A 901 (-2.3A)
IMP  A 801 ( 4.6A)
IMP  A 801 (-3.6A)
None
IMP  A 801 ( 3.2A)
None
 1.42A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 10 ASP A 261
ASN A 291
GLY A 359
GLU A 408
GLY A 407
 TAD  A 901 (-2.3A)
IMP  A 801 ( 4.6A)
IMP  A 801 (-3.3A)
None
IMP  A 801 (-3.2A)
 1.28A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		6 / 10 ASP A 261
ASN A 291
ILE A 313
GLY A 314
GLU A 408
GLY A 407
 TAD  A 901 (-2.3A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
None
IMP  A 801 (-3.2A)
 1.32A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		7 / 10 ASP A 261
ASN A 291
ILE A 313
GLY A 314
GLU A 408
GLY A 409
ARG A 414
 TAD  A 901 (-2.3A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
None
IMP  A 801 ( 3.2A)
None
 0.85A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		8 / 10 ASP A 261
SER A 262
SER A 263
ASN A 291
ILE A 313
GLY A 314
GLU A 408
GLY A 409
 TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
None
IMP  A 801 ( 3.2A)
 0.30A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 10 SER A 263
ASN A 291
GLY A 315
GLU A 408
GLY A 407
 TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
None
None
IMP  A 801 (-3.2A)
 1.26A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 10 SER A 263
ASN A 291
GLY A 359
GLU A 408
GLY A 407
 TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
IMP  A 801 (-3.3A)
None
IMP  A 801 (-3.2A)
 0.95A 1mehA-1lrtA:
58.0		 1mehA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		7 / 8 ASP A 261
SER A 262
SER A 263
ASN A 291
ILE A 313
GLU A 408
GLY A 409
 TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
None
IMP  A 801 ( 3.2A)
 0.33A 1meiA-1lrtA:
58.5		 1meiA-1lrtA:
74.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 8 SER A 263
ASN A 291
GLU A 408
GLY A 407
 TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
None
IMP  A 801 (-3.2A)
 0.91A 1meiA-1lrtA:
58.5		 1meiA-1lrtA:
74.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		6 / 11 ARG A 342
ALA A 304
VAL A 287
ILE A 260
GLY A 290
ILE A 292
 None
 1.38A 1n49B-1lrtA:
undetectable		 1n49B-1lrtA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		6 / 11 ARG A 342
ALA A 304
VAL A 287
ILE A 260
GLY A 290
ILE A 292
 None
 1.37A 1n49C-1lrtA:
undetectable		 1n49C-1lrtA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 ARG A 299
ASP A 294
ILE A 313
GLY A 265
ILE A 292
 None
None
TAD  A 901 (-4.1A)
None
None
 1.32A 1q8jA-1lrtA:
6.5		 1q8jA-1lrtA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 8 TYR A 405
GLY A 359
GLY A 381
LEU A 380
SER A 317
 IMP  A 801 (-4.6A)
IMP  A 801 (-3.3A)
IMP  A 801 (-3.5A)
None
IMP  A 801 (-2.6A)
 1.19A 1qzzA-1lrtA:
undetectable		 1qzzA-1lrtA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 10 ALA A 334
ILE A 313
GLY A 314
GLY A 315
ILE A 311
 None
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
None
None
 0.82A 1sdvA-1lrtA:
undetectable		 1sdvA-1lrtA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 ALA A 334
ILE A 313
GLY A 314
GLY A 315
ILE A 311
 None
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
None
None
 0.81A 2avvA-1lrtA:
undetectable		 2avvA-1lrtA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		3 / 3 GLY A 265
ASP A 264
SER A 262
 None
TRS  A 600 ( 3.1A)
TAD  A 901 ( 2.6A)
 0.65A 2qhfA-1lrtA:
undetectable		 2qhfA-1lrtA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 9 LEU A 380
ILE A 361
GLY A 360
GLY A 316
SER A  56
 None
None
IMP  A 801 (-4.1A)
IMP  A 801 (-3.6A)
None
 1.16A 2qmmA-1lrtA:
undetectable		 2qmmA-1lrtA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 4 LYS A 403
ALA A 385
PHE A 384
GLY A 381
 None
None
None
IMP  A 801 (-3.5A)
 1.42A 2rddA-1lrtA:
0.0		 2rddA-1lrtA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 GLY A 290
VAL A  55
SER A  63
ASP A 358
ASP A 261
 None
None
None
IMP  A 801 (-2.5A)
TAD  A 901 (-2.3A)
 1.42A 2vqyA-1lrtA:
0.1		 2vqyA-1lrtA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 9 VAL A  38
ILE A  48
LEU A 250
GLY A 235
ALA A 236
 None
 1.30A 2xf3B-1lrtA:
0.0		 2xf3B-1lrtA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B500_1
(ORF12)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 9 VAL A  38
ILE A  48
LEU A 250
GLY A 235
ALA A 236
 None
 1.28A 2xfsB-1lrtA:
0.0		 2xfsB-1lrtA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 9 VAL A  38
ILE A  48
LEU A 250
GLY A 235
ALA A 236
 None
 1.30A 2xh9B-1lrtA:
0.0		 2xh9B-1lrtA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 7 VAL A 338
ARG A 329
ASN A 291
GLY A 290
 None
None
IMP  A 801 ( 4.6A)
None
 0.83A 2y05A-1lrtA:
undetectable
2y05B-1lrtA:
undetectable		 2y05A-1lrtA:
22.08
2y05B-1lrtA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
 None
TAD  A 901 (-2.3A)
None
None
None
 0.89A 2z54A-1lrtA:
undetectable		 2z54A-1lrtA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 GLN A  84
LEU A 250
ALA A 236
VAL A 234
LEU A 443
 None
 1.29A 3b0wB-1lrtA:
0.0		 3b0wB-1lrtA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 10 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
 None
TAD  A 901 (-2.3A)
None
None
None
 0.87A 3em3A-1lrtA:
undetectable		 3em3A-1lrtA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
 None
TAD  A 901 (-2.3A)
None
None
None
 0.96A 3ndxA-1lrtA:
undetectable		 3ndxA-1lrtA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		3 / 3 ASN A 446
ALA A 440
ARG A 386
 None
 0.65A 3tj7C-1lrtA:
0.0
3tj7D-1lrtA:
0.0		 3tj7C-1lrtA:
20.00
3tj7D-1lrtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 8 PHE A 384
THR A  35
LEU A 371
VAL A 454
 None
 0.86A 3ua5A-1lrtA:
undetectable		 3ua5A-1lrtA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 8 ASP A 261
SER A 262
SER A 263
ASN A 291
GLY A 409
 TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
IMP  A 801 ( 3.2A)
 0.42A 4af0A-1lrtA:
45.3		 4af0A-1lrtA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 10 ASP A 261
SER A 262
SER A 263
ASN A 291
GLY A 409
 TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
IMP  A 801 ( 3.2A)
 0.41A 4af0B-1lrtA:
45.3		 4af0B-1lrtA:
27.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 8 ASP A 261
SER A 262
SER A 263
ASN A 291
CYH A 319
 TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
IMP  A 801 (-4.0A)
 0.88A 4fo4A-1lrtA:
47.0		 4fo4A-1lrtA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 8 SER A 262
SER A 263
ASN A 291
CYH A 319
GLY A 409
 TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
IMP  A 801 (-4.0A)
IMP  A 801 ( 3.2A)
 0.69A 4fo4A-1lrtA:
47.0		 4fo4A-1lrtA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		6 / 8 SER A 262
SER A 263
ASN A 291
GLY A 314
CYH A 319
GLY A 409
 TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-3.9A)
IMP  A 801 (-4.0A)
IMP  A 801 ( 3.2A)
 0.66A 4fo4B-1lrtA:
46.3		 4fo4B-1lrtA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		6 / 9 ASP A 261
SER A 262
SER A 263
ILE A 313
GLY A 314
CYH A 319
 TAD  A 901 (-2.3A)
TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
IMP  A 801 (-4.0A)
 0.97A 4fxsA-1lrtA:
46.8		 4fxsA-1lrtA:
30.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		7 / 9 SER A 262
SER A 263
ASN A 291
ILE A 313
GLY A 314
CYH A 319
ASP A 358
 TAD  A 901 ( 2.6A)
TAD  A 901 (-2.7A)
IMP  A 801 ( 4.6A)
TAD  A 901 (-4.1A)
TAD  A 901 (-3.9A)
IMP  A 801 (-4.0A)
IMP  A 801 (-2.5A)
 0.64A 4fxsA-1lrtA:
46.8		 4fxsA-1lrtA:
30.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		3 / 3 ARG A 299
GLU A 296
PHE A 266
 None
 0.87A 4kszA-1lrtA:
0.0		 4kszA-1lrtA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 8 ASP A 264
ASP A 358
SER A 263
ALA A 334
 TRS  A 600 ( 3.1A)
IMP  A 801 (-2.5A)
TAD  A 901 (-2.7A)
None
 0.88A 4m48A-1lrtA:
undetectable		 4m48A-1lrtA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 7 ASN A 343
GLU A 348
TYR A 345
GLU A 341
 TRS  A 607 (-3.8A)
None
None
None
 1.17A 4mi4B-1lrtA:
0.1
4mi4C-1lrtA:
0.0		 4mi4B-1lrtA:
20.89
4mi4C-1lrtA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 5 ILE A 378
LEU A  54
ASP A 364
VAL A  31
 None
 0.79A 4nkxB-1lrtA:
undetectable		 4nkxB-1lrtA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 7 ILE A  77
LEU A  71
GLY A  75
GLY A  76
 None
 0.85A 5a06B-1lrtA:
1.5		 5a06B-1lrtA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 8 GLY A 314
GLY A 315
VAL A 293
ASP A 358
 TAD  A 901 (-3.9A)
None
None
IMP  A 801 (-2.5A)
 0.76A 5f8yA-1lrtA:
undetectable		 5f8yA-1lrtA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 8 GLY A 314
GLY A 315
VAL A 293
ASP A 358
 TAD  A 901 (-3.9A)
None
None
IMP  A 801 (-2.5A)
 0.76A 5f8yB-1lrtA:
undetectable		 5f8yB-1lrtA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 8 THR A 465
LEU A 469
PRO A  53
LEU A 371
 None
 0.95A 5g48A-1lrtA:
undetectable		 5g48A-1lrtA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 8 VAL A  55
VAL A 285
ILE A 238
ILE A 277
ILE A 260
 None
 1.42A 5hi2A-1lrtA:
undetectable		 5hi2A-1lrtA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 PHE A  12
ALA A 370
ILE A 336
GLY A 312
ILE A 378
 None
 1.00A 5m24A-1lrtA:
undetectable		 5m24A-1lrtA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 6 ILE A 378
ALA A 375
LEU A 371
ILE A 466
 None
 0.86A 5mvmB-1lrtA:
undetectable
5mvmC-1lrtA:
undetectable		 5mvmB-1lrtA:
11.90
5mvmC-1lrtA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 7 LEU A 380
GLY A 360
GLY A 316
SER A  56
 None
IMP  A 801 (-4.1A)
IMP  A 801 (-3.6A)
None
 0.63A 5o96C-1lrtA:
undetectable		 5o96C-1lrtA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		3 / 3 ARG A 382
PRO A 438
TYR A 363
 None
 0.96A 5tzoB-1lrtA:
undetectable		 5tzoB-1lrtA:
20.11