SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lrv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 1lrv LEUCINE-RICH REPEAT
VARIANT
(Azotobacter
vinelandii) 		4 / 6 LEU A 212
ASP A 207
LEU A 223
HIS A 217
 None
 1.18A 1errB-1lrvA:
undetectable		 1errB-1lrvA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1lrv LEUCINE-RICH REPEAT
VARIANT
(Azotobacter
vinelandii) 		3 / 3 THR A 209
GLU A 183
ASP A 159
 None
 0.73A 1nt2A-1lrvA:
undetectable		 1nt2A-1lrvA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1lrv LEUCINE-RICH REPEAT
VARIANT
(Azotobacter
vinelandii) 		4 / 4 ALA A 191
VAL A 210
ALA A 213
HIS A 217
 None
 1.17A 1q23A-1lrvA:
0.0		 1q23A-1lrvA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1lrv LEUCINE-RICH REPEAT
VARIANT
(Azotobacter
vinelandii) 		4 / 4 ALA A 191
VAL A 210
ALA A 213
HIS A 217
 None
 1.13A 1q23K-1lrvA:
0.0		 1q23K-1lrvA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 1lrv LEUCINE-RICH REPEAT
VARIANT
(Azotobacter
vinelandii) 		4 / 6 LEU A  79
ALA A  93
LEU A  82
SER A  86
 None
 0.96A 1tz8C-1lrvA:
undetectable
1tz8D-1lrvA:
undetectable		 1tz8C-1lrvA:
18.70
1tz8D-1lrvA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 1lrv LEUCINE-RICH REPEAT
VARIANT
(Azotobacter
vinelandii) 		4 / 5 LEU A 212
ASP A 207
LEU A 223
HIS A 217
 None
 1.18A 2jfaA-1lrvA:
undetectable		 2jfaA-1lrvA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 1lrv LEUCINE-RICH REPEAT
VARIANT
(Azotobacter
vinelandii) 		4 / 5 LEU A 212
ASP A 207
LEU A 223
HIS A 217
 None
 1.15A 2qxsA-1lrvA:
0.0		 2qxsA-1lrvA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 1lrv LEUCINE-RICH REPEAT
VARIANT
(Azotobacter
vinelandii) 		4 / 5 LEU A 212
ASP A 207
LEU A 223
HIS A 217
 None
 1.17A 2qxsB-1lrvA:
0.0		 2qxsB-1lrvA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 1lrv LEUCINE-RICH REPEAT
VARIANT
(Azotobacter
vinelandii) 		4 / 8 SER A  86
LEU A  79
ALA A  93
LEU A  82
 None
 0.79A 4ikjA-1lrvA:
undetectable
4ikjB-1lrvA:
undetectable		 4ikjA-1lrvA:
18.70
4ikjB-1lrvA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1lrv LEUCINE-RICH REPEAT
VARIANT
(Azotobacter
vinelandii) 		4 / 8 LEU A  79
ALA A  93
LEU A  82
SER A  86
 None
 0.71A 4ikkA-1lrvA:
undetectable
4ikkB-1lrvA:
undetectable		 4ikkA-1lrvA:
18.70
4ikkB-1lrvA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 1lrv LEUCINE-RICH REPEAT
VARIANT
(Azotobacter
vinelandii) 		4 / 8 SER A  86
LEU A  79
ALA A  93
LEU A  82
 None
 0.65A 4iklA-1lrvA:
undetectable
4iklB-1lrvA:
undetectable		 4iklA-1lrvA:
18.70
4iklB-1lrvA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 1lrv LEUCINE-RICH REPEAT
VARIANT
(Azotobacter
vinelandii) 		4 / 5 LEU A  59
ASP A  61
ARG A  66
ILE A  44
 None
 1.50A 4mwrA-1lrvA:
undetectable		 4mwrA-1lrvA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1lrv LEUCINE-RICH REPEAT
VARIANT
(Azotobacter
vinelandii) 		5 / 12 LEU A 106
LEU A  98
ARG A  91
LEU A  82
ILE A  83
 None
 1.13A 4x1gA-1lrvA:
0.0		 4x1gA-1lrvA:
21.17