SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lrw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		3 / 3 ALA A 112
VAL A  15
TRP A  14
 None
 0.92A 1c4dC-1lrwA:
undetectable
1c4dD-1lrwA:
undetectable		 1c4dC-1lrwA:
3.12
1c4dD-1lrwA:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 9 PHE A  66
ILE A 124
GLY A 110
ASN A 108
TYR A 246
 None
 1.20A 1i00B-1lrwA:
0.0		 1i00B-1lrwA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 LEU A 325
LEU A 338
SER A 347
LEU A 363
THR A 341
 None
 1.07A 1kw0A-1lrwA:
undetectable		 1kw0A-1lrwA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		3 / 3 PHE A 255
LEU A 170
MET A 194
 None
 0.91A 1mx1D-1lrwA:
undetectable		 1mx1D-1lrwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 9 GLY A 573
GLU A  55
GLY A  53
GLY A 518
GLY A  56
 None
PQQ  A 701 (-2.6A)
None
None
None
 1.10A 1mxdA-1lrwA:
0.0		 1mxdA-1lrwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 11 GLY A 573
GLU A  55
GLY A  53
GLY A 518
GLY A  56
 None
PQQ  A 701 (-2.6A)
None
None
None
 1.08A 1mxgA-1lrwA:
undetectable		 1mxgA-1lrwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 THR A  57
GLY A 518
GLU A  55
GLY A 396
VAL A 575
 None
None
PQQ  A 701 (-2.6A)
None
None
 1.26A 1n2xA-1lrwA:
undetectable		 1n2xA-1lrwA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 GLY A 333
ALA A 348
MET A 351
GLY A 306
HIS A 328
 None
 1.06A 1nbiC-1lrwA:
undetectable		 1nbiC-1lrwA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 GLY A 333
ALA A 348
MET A 351
GLY A 306
HIS A 328
 None
 1.06A 1nbiD-1lrwA:
undetectable		 1nbiD-1lrwA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 8 ARG A  99
GLY A  53
VAL A 107
ILE A 517
 None
None
PQQ  A 701 (-4.7A)
None
 0.64A 1pk7B-1lrwA:
undetectable		 1pk7B-1lrwA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 6 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.86A 1v54A-1lrwA:
undetectable
1v54J-1lrwA:
0.0		 1v54A-1lrwA:
21.34
1v54J-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 7 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.92A 1v55A-1lrwA:
undetectable
1v55J-1lrwA:
0.0		 1v55A-1lrwA:
21.34
1v55J-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 LEU A 158
GLY A 131
HIS A 132
ILE A 133
 None
 0.72A 1xf1A-1lrwA:
undetectable		 1xf1A-1lrwA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 6 LEU A 158
GLY A 131
HIS A 132
ILE A 133
 None
 0.74A 1xf1B-1lrwA:
undetectable		 1xf1B-1lrwA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 TYR A 304
PRO A 298
PRO A 387
ILE A 334
LEU A 345
 None
 1.07A 1z9hA-1lrwA:
0.0		 1z9hA-1lrwA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 TYR A 304
PRO A 298
PRO A 387
ILE A 334
LEU A 345
 None
 1.07A 1z9hB-1lrwA:
undetectable		 1z9hB-1lrwA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 TYR A 304
PRO A 298
PRO A 387
ILE A 334
LEU A 345
 None
 1.07A 1z9hC-1lrwA:
0.0		 1z9hC-1lrwA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 6 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.81A 2dyrA-1lrwA:
undetectable
2dyrJ-1lrwA:
0.0		 2dyrA-1lrwA:
21.34
2dyrJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 6 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.82A 2dysA-1lrwA:
undetectable
2dysJ-1lrwA:
0.0		 2dysA-1lrwA:
21.34
2dysJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 6 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.93A 2dysN-1lrwA:
undetectable
2dysW-1lrwA:
0.0		 2dysN-1lrwA:
21.34
2dysW-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 6 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.88A 2eijA-1lrwA:
undetectable
2eijJ-1lrwA:
0.0		 2eijA-1lrwA:
21.34
2eijJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 6 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.88A 2eilA-1lrwA:
undetectable
2eilJ-1lrwA:
0.0		 2eilA-1lrwA:
21.34
2eilJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.90A 2eimJ-1lrwA:
0.0		 2eimJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 446
MET A 438
THR A 437
LEU A 436
 None
 1.31A 2eimJ-1lrwA:
0.0		 2eimJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.93A 2eimW-1lrwA:
0.0		 2eimW-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 446
MET A 438
THR A 437
LEU A 436
 None
 1.32A 2eimW-1lrwA:
0.0		 2eimW-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 8 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.88A 2einA-1lrwA:
undetectable
2einJ-1lrwA:
undetectable		 2einA-1lrwA:
21.34
2einJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 6 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.93A 2einN-1lrwA:
undetectable
2einW-1lrwA:
0.0		 2einN-1lrwA:
21.34
2einW-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 7 TYR A 183
GLY A 172
THR A 185
TYR A 187
ASN A 242
 None
 1.36A 2g70A-1lrwA:
undetectable		 2g70A-1lrwA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 7 TYR A 183
GLY A 172
THR A 185
TYR A 187
ASN A 242
 None
 1.35A 2g70B-1lrwA:
undetectable		 2g70B-1lrwA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 6 TYR A 183
GLY A 172
TYR A 187
ASN A 242
 None
 1.06A 2g72A-1lrwA:
undetectable		 2g72A-1lrwA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 7 TYR A 183
GLY A 172
TYR A 187
ASN A 242
 None
 1.04A 2g72B-1lrwA:
undetectable		 2g72B-1lrwA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 6 ARG A  99
PHE A  71
PRO A  70
THR A  74
 None
 1.17A 2m2oB-1lrwA:
undetectable		 2m2oB-1lrwA:
3.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 GLY A  56
GLY A 478
GLY A 518
LEU A 409
VAL A 309
 None
 1.07A 2oxtA-1lrwA:
undetectable		 2oxtA-1lrwA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 6 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.77A 2zxwA-1lrwA:
undetectable
2zxwJ-1lrwA:
0.0		 2zxwA-1lrwA:
21.34
2zxwJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 6 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.77A 3abmA-1lrwA:
undetectable
3abmJ-1lrwA:
0.0		 3abmA-1lrwA:
21.34
3abmJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.87A 3ag1J-1lrwA:
0.0		 3ag1J-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 446
MET A 438
THR A 437
LEU A 436
 None
 1.25A 3ag1J-1lrwA:
0.0		 3ag1J-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 6 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.82A 3ag1N-1lrwA:
undetectable
3ag1W-1lrwA:
0.0		 3ag1N-1lrwA:
21.34
3ag1W-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.90A 3ag2J-1lrwA:
undetectable		 3ag2J-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 446
MET A 438
THR A 437
LEU A 436
 None
 1.32A 3ag2J-1lrwA:
undetectable		 3ag2J-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 7 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.87A 3ag3A-1lrwA:
undetectable
3ag3J-1lrwA:
undetectable		 3ag3A-1lrwA:
21.34
3ag3J-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 8 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.78A 3ag3N-1lrwA:
undetectable
3ag3W-1lrwA:
0.0		 3ag3N-1lrwA:
21.34
3ag3W-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.78A 3ag4J-1lrwA:
undetectable		 3ag4J-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 446
MET A 438
THR A 437
LEU A 436
 None
 1.17A 3ag4J-1lrwA:
undetectable		 3ag4J-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 6 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.81A 3asnA-1lrwA:
undetectable
3asnJ-1lrwA:
undetectable		 3asnA-1lrwA:
21.34
3asnJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 6 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.80A 3asoA-1lrwA:
undetectable
3asoJ-1lrwA:
undetectable		 3asoA-1lrwA:
21.34
3asoJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		3 / 3 GLY A 518
GLY A 396
GLY A 477
 None
 0.43A 3bogC-1lrwA:
undetectable		 3bogC-1lrwA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		3 / 3 GLY A 518
GLY A 396
GLY A 477
 None
 0.39A 3bogD-1lrwA:
undetectable		 3bogD-1lrwA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 8 LYS A 324
TYR A  26
GLU A 251
GLU A 314
 None
 1.21A 3dh0A-1lrwA:
undetectable		 3dh0A-1lrwA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 LYS A 324
TYR A  26
GLU A 251
GLU A 314
 None
 1.15A 3dh0B-1lrwA:
0.0		 3dh0B-1lrwA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 8 ILE A 517
GLY A 539
SER A 558
ASN A 394
 None
PQQ  A 701 (-3.4A)
None
PQQ  A 701 ( 3.9A)
 0.86A 3lslA-1lrwA:
undetectable
3lslD-1lrwA:
undetectable		 3lslA-1lrwA:
17.30
3lslD-1lrwA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 8 SER A 558
ASN A 394
ILE A 517
GLY A 539
 None
PQQ  A 701 ( 3.9A)
None
PQQ  A 701 (-3.4A)
 0.79A 3lslA-1lrwA:
undetectable
3lslD-1lrwA:
undetectable		 3lslA-1lrwA:
17.30
3lslD-1lrwA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		3 / 3 GLY A 478
TRP A 245
VAL A 309
 None
 0.65A 3n62B-1lrwA:
0.0		 3n62B-1lrwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		3 / 3 GLY A 478
TRP A 245
VAL A 309
 None
 0.63A 3n65B-1lrwA:
undetectable		 3n65B-1lrwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		3 / 3 GLY A 478
TRP A 245
VAL A 309
 None
 0.63A 3n66B-1lrwA:
undetectable		 3n66B-1lrwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2
(Paracoccus
denitrificans) 		4 / 5 GLY A 131
ASP A 130
ARG A 126
MET B  58
 None
 1.12A 3qx3A-1lrwA:
undetectable		 3qx3A-1lrwA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 8 ASP A 303
GLY A 306
GLU A 177
ARG A 109
 CA  A 702 (-3.4A)
None
CA  A 702 ( 2.1A)
PQQ  A 701 (-3.5A)
 0.95A 3s3mA-1lrwA:
undetectable		 3s3mA-1lrwA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 6 GLY A 375
GLU A 301
ASP A 273
ASP A 371
 None
 0.85A 3vywC-1lrwA:
undetectable		 3vywC-1lrwA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 ASP A 330
ASN A 308
GLY A 260
ASN A 261
ARG A 270
 None
None
None
CA  A 702 (-3.1A)
None
 1.32A 4djeB-1lrwA:
undetectable		 4djeB-1lrwA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 8 LEU A 170
PHE A 125
ASP A 188
TYR A 187
 None
 0.93A 4drjB-1lrwA:
undetectable		 4drjB-1lrwA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 11 ALA A 176
GLY A 239
GLY A 258
ASN A 261
TRP A 243
 PQQ  A 701 (-2.8A)
None
None
CA  A 702 (-3.1A)
PQQ  A 701 (-3.7A)
 1.21A 4e47A-1lrwA:
undetectable		 4e47A-1lrwA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 11 ALA A 176
GLY A 239
GLY A 258
ASN A 261
TRP A 243
 PQQ  A 701 (-2.8A)
None
None
CA  A 702 (-3.1A)
PQQ  A 701 (-3.7A)
 1.24A 4e47B-1lrwA:
undetectable		 4e47B-1lrwA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 11 ALA A 176
GLY A 239
GLY A 258
ASN A 261
TRP A 243
 PQQ  A 701 (-2.8A)
None
None
CA  A 702 (-3.1A)
PQQ  A 701 (-3.7A)
 1.26A 4e47C-1lrwA:
undetectable		 4e47C-1lrwA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 9 PHE A  66
ILE A 124
GLY A 110
ASN A 108
TYR A 246
 None
 1.22A 4eb4C-1lrwA:
undetectable		 4eb4C-1lrwA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 9 GLY A 538
GLY A 542
GLY A  53
PHE A 547
ASP A 105
 None
 1.33A 4h2gA-1lrwA:
undetectable		 4h2gA-1lrwA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 11 ALA A 176
GLY A 239
GLY A 258
ASN A 261
TRP A 243
 PQQ  A 701 (-2.8A)
None
None
CA  A 702 (-3.1A)
PQQ  A 701 (-3.7A)
 1.22A 4jdsA-1lrwA:
undetectable		 4jdsA-1lrwA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 11 ALA A 176
GLY A 239
GLY A 258
ASN A 261
TRP A 243
 PQQ  A 701 (-2.8A)
None
None
CA  A 702 (-3.1A)
PQQ  A 701 (-3.7A)
 1.20A 4jdsB-1lrwA:
undetectable		 4jdsB-1lrwA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 11 ALA A 176
GLY A 239
GLY A 258
ASN A 261
TRP A 243
 PQQ  A 701 (-2.8A)
None
None
CA  A 702 (-3.1A)
PQQ  A 701 (-3.7A)
 1.27A 4jdsC-1lrwA:
undetectable		 4jdsC-1lrwA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 ALA A 176
GLY A 239
GLY A 258
ASN A 261
TRP A 243
 PQQ  A 701 (-2.8A)
None
None
CA  A 702 (-3.1A)
PQQ  A 701 (-3.7A)
 1.15A 4jlgA-1lrwA:
0.0		 4jlgA-1lrwA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 4 TYR A 246
THR A 185
VAL A 169
ILE A 160
 None
 1.32A 4jx1F-1lrwA:
0.0		 4jx1F-1lrwA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 GLY A 240
GLY A 182
THR A 277
ASN A 261
GLY A 258
 None
None
None
CA  A 702 (-3.1A)
None
 1.09A 4n48A-1lrwA:
undetectable		 4n48A-1lrwA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 GLY A 240
GLY A 182
THR A 277
ASN A 261
GLY A 258
 None
None
None
CA  A 702 (-3.1A)
None
 1.08A 4n48B-1lrwA:
undetectable		 4n48B-1lrwA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		3 / 3 ASP A 253
LEU A 254
PHE A 255
 None
 0.65A 4pthA-1lrwA:
undetectable		 4pthA-1lrwA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 HIS A 132
THR A 157
ARG A 197
GLY A 172
THR A 185
 None
 1.10A 4qvnH-1lrwA:
undetectable
4qvnN-1lrwA:
undetectable		 4qvnH-1lrwA:
16.38
4qvnN-1lrwA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 11 HIS A 132
THR A 157
ARG A 197
GLY A 172
THR A 185
 None
 1.10A 4qvpV-1lrwA:
undetectable
4qvpb-1lrwA:
undetectable		 4qvpV-1lrwA:
16.38
4qvpb-1lrwA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 11 HIS A 132
THR A 157
ARG A 197
GLY A 172
THR A 185
 None
 1.10A 4qvpH-1lrwA:
undetectable
4qvpN-1lrwA:
undetectable		 4qvpH-1lrwA:
16.38
4qvpN-1lrwA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2
(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		5 / 12 SER B  43
GLY B  41
ALA A 176
GLY A 182
TYR A 183
 None
None
PQQ  A 701 (-2.8A)
None
None
 1.26A 4r29B-1lrwB:
undetectable		 4r29B-1lrwB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2
(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		5 / 12 SER B  43
GLY B  41
ALA A 176
GLY A 182
TYR A 183
 None
None
PQQ  A 701 (-2.8A)
None
None
 1.20A 4r29C-1lrwB:
undetectable		 4r29C-1lrwB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2
(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		4 / 5 GLY B  41
ARG A 181
GLU A 206
PHE A 199
 None
 0.91A 4r82A-1lrwB:
undetectable
4r82B-1lrwB:
undetectable		 4r82A-1lrwB:
16.85
4r82B-1lrwB:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 GLY A 182
GLY A 240
GLY A 175
ALA A 176
ILE A 152
 None
None
PQQ  A 701 (-3.7A)
PQQ  A 701 (-2.8A)
None
 0.90A 4rtmA-1lrwA:
undetectable		 4rtmA-1lrwA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 4 TYR A 183
THR A 185
GLY A 172
LEU A 158
 None
 1.29A 4w5nA-1lrwA:
0.0		 4w5nA-1lrwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2
(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		4 / 5 TYR B   1
LYS B  16
PRO B  17
GLU A 267
 None
 1.49A 4w5tA-1lrwB:
undetectable		 4w5tA-1lrwB:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2
(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		4 / 5 TYR B  19
LYS B  16
PRO B  15
GLU A 301
 None
 1.32A 4w5tA-1lrwB:
undetectable		 4w5tA-1lrwB:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 11 ALA A 176
GLY A 239
GLY A 258
ASN A 261
TRP A 243
 PQQ  A 701 (-2.8A)
None
None
CA  A 702 (-3.1A)
PQQ  A 701 (-3.7A)
 1.29A 5ayfA-1lrwA:
undetectable		 5ayfA-1lrwA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 8 HIS A  68
ASN A 108
HIS A 519
THR A  17
 None
 1.31A 5db5A-1lrwA:
undetectable
5db5B-1lrwA:
undetectable		 5db5A-1lrwA:
21.02
5db5B-1lrwA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 10 GLY A 451
GLY A 453
SER A 474
LEU A 452
TYR A 392
 None
 1.41A 5hwkA-1lrwA:
0.0		 5hwkA-1lrwA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 10 GLY A 451
GLY A 453
SER A 474
LEU A 452
TYR A 392
 None
 1.41A 5hwkB-1lrwA:
undetectable		 5hwkB-1lrwA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2
(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		3 / 3 GLY A 239
GLY A 238
GLN B  40
 None
 0.48A 5imsA-1lrwA:
undetectable		 5imsA-1lrwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 7 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.88A 5iy5N-1lrwA:
undetectable
5iy5W-1lrwA:
undetectable		 5iy5N-1lrwA:
21.34
5iy5W-1lrwA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2
(Paracoccus
denitrificans) 		4 / 5 TYR B   1
GLY B   3
THR B   4
GLY A 182
 None
 0.73A 5jlcA-1lrwB:
undetectable		 5jlcA-1lrwB:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		3 / 3 VAL A 307
ARG A 126
PRO A 162
 None
 0.83A 5koxA-1lrwA:
undetectable		 5koxA-1lrwA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 7 GLY A 260
ALA A 263
ASP A 303
ASN A 242
 None
None
CA  A 702 (-3.4A)
None
 1.00A 5mvsA-1lrwA:
undetectable		 5mvsA-1lrwA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 8 GLY A 260
ALA A 263
ASP A 303
ASN A 242
 None
None
CA  A 702 (-3.4A)
None
 0.93A 5mvsB-1lrwA:
undetectable		 5mvsB-1lrwA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 7 LEU A 367
ILE A 346
ASP A 364
ASN A 217
 None
 0.95A 5n5dA-1lrwA:
undetectable		 5n5dA-1lrwA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		3 / 3 TYR A 294
ALA A 348
TYR A 336
 None
 0.87A 5uunB-1lrwA:
0.0		 5uunB-1lrwA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 GLY A 239
LYS A 236
ASP A 300
GLY A 306
SER A 259
 None
 1.15A 5vooF-1lrwA:
undetectable		 5vooF-1lrwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 GLY A 239
LYS A 236
ASP A 300
GLY A 306
SER A 259
 None
 1.15A 5vopB-1lrwA:
undetectable		 5vopB-1lrwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		3 / 3 GLY A 478
TRP A 245
VAL A 309
 None
 0.65A 5vuoB-1lrwA:
undetectable		 5vuoB-1lrwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 TYR A 439
SER A 388
ILE A 385
GLU A 419
THR A 376
 None
 1.30A 5w8aA-1lrwA:
undetectable		 5w8aA-1lrwA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 1.12A 5w97J-1lrwA:
0.0		 5w97J-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.89A 5wauJ-1lrwA:
0.0		 5wauJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 446
MET A 438
THR A 437
LEU A 436
 None
 1.24A 5wauJ-1lrwA:
0.0		 5wauJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 1.10A 5x19J-1lrwA:
undetectable		 5x19J-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 446
MET A 438
THR A 437
LEU A 436
 None
 1.26A 5x19J-1lrwA:
undetectable		 5x19J-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 1.17A 5x1bJ-1lrwA:
0.0		 5x1bJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 446
MET A 438
THR A 437
LEU A 436
 None
 1.32A 5x1bJ-1lrwA:
0.0		 5x1bJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.85A 5x1bW-1lrwA:
undetectable		 5x1bW-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 446
MET A 438
THR A 437
LEU A 436
 None
 1.20A 5x1bW-1lrwA:
undetectable		 5x1bW-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 6 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.86A 5x1fA-1lrwA:
undetectable
5x1fJ-1lrwA:
0.0		 5x1fA-1lrwA:
21.34
5x1fJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.87A 5x1fW-1lrwA:
0.0		 5x1fW-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 446
MET A 438
THR A 437
LEU A 436
 None
 1.27A 5x1fW-1lrwA:
0.0		 5x1fW-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 7 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.88A 5xdxA-1lrwA:
undetectable
5xdxJ-1lrwA:
undetectable		 5xdxA-1lrwA:
21.34
5xdxJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		3 / 3 LYS A 497
LEU A 506
ARG A 499
 None
 0.89A 5yw0A-1lrwA:
0.0		 5yw0A-1lrwA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		3 / 3 MET A 278
ASP A 303
ARG A 109
 None
CA  A 702 (-3.4A)
PQQ  A 701 (-3.5A)
 1.19A 5z6kA-1lrwA:
undetectable		 5z6kA-1lrwA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 6 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 1.01A 5zcoN-1lrwA:
undetectable
5zcoW-1lrwA:
0.0		 5zcoN-1lrwA:
21.34
5zcoW-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2
(Paracoccus
denitrificans) 		4 / 5 GLY A 131
ASP A 130
ARG A 126
MET B  58
 None
 1.12A 5zrfB-1lrwA:
undetectable		 5zrfB-1lrwA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2
(Paracoccus
denitrificans) 		4 / 4 GLY A 131
ASP A 130
ARG A 126
MET B  58
 None
 1.15A 5zrfA-1lrwA:
0.0		 5zrfA-1lrwA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 10 GLY A 260
GLY A 306
ASP A 303
THR A 277
ASN A 274
 None
None
CA  A 702 (-3.4A)
None
None
 1.17A 6exiA-1lrwA:
undetectable		 6exiA-1lrwA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 10 GLY A 260
GLY A 306
ASP A 303
THR A 277
ASN A 274
 None
None
CA  A 702 (-3.4A)
None
None
 1.17A 6exiB-1lrwA:
undetectable		 6exiB-1lrwA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 GLY A 260
GLY A 306
ASP A 303
THR A 277
ASN A 274
 None
None
CA  A 702 (-3.4A)
None
None
 1.18A 6exiC-1lrwA:
undetectable
6exiD-1lrwA:
undetectable		 6exiC-1lrwA:
10.19
6exiD-1lrwA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 GLY A 260
GLY A 306
ASP A 303
THR A 277
ASN A 274
 None
None
CA  A 702 (-3.4A)
None
None
 1.16A 6exiC-1lrwA:
undetectable
6exiD-1lrwA:
undetectable		 6exiC-1lrwA:
10.19
6exiD-1lrwA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 6 ARG A  99
PHE A  71
VAL A 107
PRO A  70
 None
None
PQQ  A 701 (-4.7A)
None
 1.27A 6fgdA-1lrwA:
undetectable		 6fgdA-1lrwA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 8 GLY A 539
GLY A 555
SER A 558
ALA A 561
 PQQ  A 701 (-3.4A)
None
None
None
 0.57A 6hu9H-1lrwA:
undetectable
6hu9e-1lrwA:
0.0		 6hu9H-1lrwA:
8.97
6hu9e-1lrwA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 HIS A 132
THR A 157
ARG A 197
GLY A 172
THR A 185
 None
 1.10A 6hwdV-1lrwA:
undetectable
6hwdb-1lrwA:
undetectable		 6hwdV-1lrwA:
8.96
6hwdb-1lrwA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 12 HIS A 132
THR A 157
ARG A 197
GLY A 172
THR A 185
 None
 1.10A 6hwdH-1lrwA:
undetectable
6hwdN-1lrwA:
undetectable		 6hwdH-1lrwA:
8.96
6hwdN-1lrwA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 11 GLY A 557
GLY A 555
VAL A 543
MET A 438
ASP A 303
 None
None
None
None
CA  A 702 (-3.4A)
 1.13A 6i5zD-1lrwA:
undetectable		 6i5zD-1lrwA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 7 GLY A  49
HIS A  68
GLU A  55
GLY A  53
 None
None
PQQ  A 701 (-2.6A)
None
 0.95A 6n7fA-1lrwA:
undetectable		 6n7fA-1lrwA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.84A 6nknJ-1lrwA:
0.0		 6nknJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 5 ARG A 446
MET A 438
THR A 437
LEU A 436
 None
 1.20A 6nknJ-1lrwA:
0.0		 6nknJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 7 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.88A 6nmfA-1lrwA:
undetectable
6nmfJ-1lrwA:
0.0		 6nmfA-1lrwA:
21.34
6nmfJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		4 / 7 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.91A 6nmpA-1lrwA:
undetectable
6nmpJ-1lrwA:
0.0		 6nmpA-1lrwA:
21.34
6nmpJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
(Paracoccus
denitrificans) 		5 / 11 GLY A 202
LEU A 209
ALA A 290
ARG A 283
ALA A 198
 None
 1.47A 6qgbE-1lrwA:
undetectable		 6qgbE-1lrwA:
21.65