SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lrz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		5 / 12 LEU A  57
LEU A  42
LEU A   6
LEU A  34
THR A  59
 None
 1.42A 1a28B-1lrzA:
undetectable		 1a28B-1lrzA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQU_A_ESTA304_1
(ESTROGEN
SULFOTRANSFERASE)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		5 / 11 TYR A 393
ASN A 128
HIS A 158
PHE A 323
GLU A  81
 None
 1.28A 1aquA-1lrzA:
0.0
1aquB-1lrzA:
0.0		 1aquA-1lrzA:
22.93
1aquB-1lrzA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		3 / 3 ARG A 235
GLY A  12
ASP A  16
 None
 0.31A 1kf6A-1lrzA:
4.5
1kf6B-1lrzA:
undetectable		 1kf6A-1lrzA:
21.41
1kf6B-1lrzA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		4 / 8 TYR A 327
TYR A 361
GLN A 346
TYR A 225
 None
 1.11A 1nx9A-1lrzA:
undetectable		 1nx9A-1lrzA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		4 / 8 TYR A 327
TYR A 361
GLN A 346
TYR A 225
 None
 1.11A 1nx9B-1lrzA:
undetectable		 1nx9B-1lrzA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		4 / 8 TYR A 327
TYR A 361
GLN A 346
TYR A 225
 None
 1.10A 1nx9C-1lrzA:
2.5		 1nx9C-1lrzA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		4 / 8 TYR A 327
TYR A 361
GLN A 346
TYR A 225
 None
 1.10A 1nx9D-1lrzA:
2.5		 1nx9D-1lrzA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		4 / 6 TYR A 327
SER A 314
ALA A 315
THR A 332
 None
 0.85A 1yvpB-1lrzA:
2.3		 1yvpB-1lrzA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		5 / 12 LEU A 105
ILE A 107
PHE A  90
GLY A  44
PHE A 140
 None
 1.08A 1zz1B-1lrzA:
undetectable
1zz1C-1lrzA:
undetectable		 1zz1B-1lrzA:
21.48
1zz1C-1lrzA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		5 / 8 TYR A 225
ARG A 205
GLY A 331
GLY A 316
ALA A 329
 None
 1.49A 2ej3C-1lrzA:
undetectable		 2ej3C-1lrzA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		4 / 7 TYR A 327
SER A 314
ALA A 315
THR A 332
 None
 0.90A 2i91A-1lrzA:
2.9		 2i91A-1lrzA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		4 / 7 TYR A 327
SER A 314
ALA A 315
THR A 332
 None
 0.90A 2i91B-1lrzA:
undetectable		 2i91B-1lrzA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		4 / 8 TYR A 328
ARG A 228
HIS A  29
GLN A  25
 None
 1.44A 2vxaA-1lrzA:
0.0
2vxaC-1lrzA:
0.0
2vxaE-1lrzA:
0.0		 2vxaA-1lrzA:
9.14
2vxaC-1lrzA:
9.14
2vxaE-1lrzA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		4 / 8 TYR A 328
ARG A 228
HIS A  29
GLN A  25
 None
 1.45A 2vxaA-1lrzA:
0.0
2vxaB-1lrzA:
0.0
2vxaK-1lrzA:
0.0		 2vxaA-1lrzA:
9.14
2vxaB-1lrzA:
9.14
2vxaK-1lrzA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		4 / 8 TYR A 328
ARG A 228
HIS A  29
GLN A  25
 None
 1.45A 2vxaB-1lrzA:
0.0
2vxaC-1lrzA:
0.0
2vxaG-1lrzA:
0.0		 2vxaB-1lrzA:
9.14
2vxaC-1lrzA:
9.14
2vxaG-1lrzA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		4 / 8 TYR A 328
ARG A 228
HIS A  29
GLN A  25
 None
 1.44A 2vxaD-1lrzA:
0.0
2vxaF-1lrzA:
0.0
2vxaI-1lrzA:
0.0		 2vxaD-1lrzA:
9.14
2vxaF-1lrzA:
9.14
2vxaI-1lrzA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		4 / 8 TYR A 328
ARG A 228
HIS A  29
GLN A  25
 None
 1.45A 2vxaD-1lrzA:
0.0
2vxaE-1lrzA:
0.0
2vxaL-1lrzA:
0.0		 2vxaD-1lrzA:
9.14
2vxaE-1lrzA:
9.14
2vxaL-1lrzA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		4 / 8 HIS A  29
GLN A  25
TYR A 328
ARG A 228
 None
 1.45A 2vxaF-1lrzA:
0.0
2vxaG-1lrzA:
0.0
2vxaI-1lrzA:
0.0		 2vxaF-1lrzA:
9.14
2vxaG-1lrzA:
9.14
2vxaI-1lrzA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		4 / 8 HIS A  29
GLN A  25
TYR A 328
ARG A 228
 None
 1.43A 2vxaB-1lrzA:
0.0
2vxaG-1lrzA:
0.0
2vxaH-1lrzA:
0.0		 2vxaB-1lrzA:
9.14
2vxaG-1lrzA:
9.14
2vxaH-1lrzA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		4 / 8 TYR A 328
ARG A 228
HIS A  29
GLN A  25
 None
 1.44A 2vxaH-1lrzA:
0.0
2vxaI-1lrzA:
0.0
2vxaJ-1lrzA:
0.0		 2vxaH-1lrzA:
9.14
2vxaI-1lrzA:
9.14
2vxaJ-1lrzA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		4 / 8 HIS A  29
GLN A  25
TYR A 328
ARG A 228
 None
 1.45A 2vxaD-1lrzA:
0.0
2vxaJ-1lrzA:
0.0
2vxaL-1lrzA:
0.0		 2vxaD-1lrzA:
9.14
2vxaJ-1lrzA:
9.14
2vxaL-1lrzA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		4 / 8 HIS A  29
GLN A  25
TYR A 328
ARG A 228
 None
 1.43A 2vxaH-1lrzA:
0.0
2vxaJ-1lrzA:
0.0
2vxaK-1lrzA:
0.0		 2vxaH-1lrzA:
9.14
2vxaJ-1lrzA:
9.14
2vxaK-1lrzA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		4 / 8 HIS A  29
GLN A  25
TYR A 328
ARG A 228
 None
 1.44A 2vxaA-1lrzA:
0.0
2vxaK-1lrzA:
0.0
2vxaL-1lrzA:
0.0		 2vxaA-1lrzA:
9.14
2vxaK-1lrzA:
9.14
2vxaL-1lrzA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		3 / 3 MET A  18
GLU A  51
ASN A  48
 None
 1.02A 3a27A-1lrzA:
undetectable		 3a27A-1lrzA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		5 / 12 PHE A  70
LEU A  93
VAL A  43
VAL A  97
CYH A  56
 None
 1.22A 3u9fJ-1lrzA:
0.0
3u9fK-1lrzA:
0.0		 3u9fJ-1lrzA:
19.41
3u9fK-1lrzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		3 / 3 SER A 159
ASP A 376
ASP A 373
 None
 0.92A 3uj7A-1lrzA:
undetectable		 3uj7A-1lrzA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		4 / 7 TYR A  71
ASP A 108
TYR A 364
HIS A  22
 None
 1.25A 4arcA-1lrzA:
undetectable		 4arcA-1lrzA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		4 / 6 TYR A 393
TYR A  20
TYR A 110
PHE A 323
 None
 0.85A 4g10A-1lrzA:
3.3		 4g10A-1lrzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE
(Staphylococcus
aureus) 		3 / 3 HIS A 356
ASN A 355
LEU A 354
 None
 0.91A 6f7lB-1lrzA:
undetectable		 6f7lB-1lrzA:
21.41