SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ls4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Y0X_X_T44X500_2 (THYROID HORMONE RECEPTOR BETA-1)	1ls4	APOLIPOPHORIN-III (Locusta migratoria)	4 / 5	ILE A 88 ARG A 82 LEU A 84 ASN A 85	None	1.10A	1y0xX-1ls4A: undetectable	1y0xX-1ls4A: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ADS_A_IMNA2_2 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	1ls4	APOLIPOPHORIN-III (Locusta migratoria)	4 / 6	ILE A 118 ILE A 21 LEU A 77 PHE A 80	None	0.77A	3adsA-1ls4A: undetectable	3adsA-1ls4A: 21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ADX_A_IMNA2_2 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	1ls4	APOLIPOPHORIN-III (Locusta migratoria)	4 / 7	ILE A 118 ILE A 21 LEU A 77 PHE A 80	None	0.78A	3adxA-1ls4A: undetectable	3adxA-1ls4A: 21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R3A_A_RBFA402_1 (BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2)	1ls4	APOLIPOPHORIN-III (Locusta migratoria)	5 / 12	ALA A 91 GLN A 47 ALA A 147 ILE A 155 LEU A 28	None	1.17A	4r3aA-1ls4A: undetectable	4r3aA-1ls4A: 18.68

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1Y0X_X_T44X500_2","THYROID HORMONE RECEPTOR BETA-1","1ls4","APOLIPOPHORIN-III","Locusta migratoria",4,"ILE A  88;ARG A  82;LEU A  84;ASN A  85","None","1.10A","1y0xX-1ls4A:undetectable","1y0xX-1ls4A:19.93"],["3ADS_A_IMNA2_2","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","1ls4","APOLIPOPHORIN-III","Locusta migratoria",4,"ILE A 118;ILE A  21;LEU A  77;PHE A  80","None","0.77A","3adsA-1ls4A:undetectable","3adsA-1ls4A:21.80"],["3ADX_A_IMNA2_2","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","1ls4","APOLIPOPHORIN-III","Locusta migratoria",4,"ILE A 118;ILE A  21;LEU A  77;PHE A  80","None","0.78A","3adxA-1ls4A:undetectable","3adxA-1ls4A:21.80"],["4R3A_A_RBFA402_1","BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2","1ls4","APOLIPOPHORIN-III","Locusta migratoria",5,"ALA A  91;GLN A  47;ALA A 147;ILE A 155;LEU A  28","None","1.17A","4r3aA-1ls4A:undetectable","4r3aA-1ls4A:18.68"]]