SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lsh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 7 LEU A 416
GLU A 472
LEU A 460
LEU A 433
GLY A 434
 None
None
None
None
PLD  A2005 ( 4.6A)
 1.48A 1n13D-1lshA:
undetectable
1n13E-1lshA:
0.0		 1n13D-1lshA:
7.70
1n13E-1lshA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 8 ARG A 679
TYR A 742
GLU A 545
SER A 649
 None
 1.33A 1nx9A-1lshA:
undetectable		 1nx9A-1lshA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 8 ARG A 679
TYR A 742
GLU A 545
SER A 649
 None
 1.33A 1nx9B-1lshA:
undetectable		 1nx9B-1lshA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 8 ARG A 679
TYR A 742
GLU A 545
SER A 649
 None
 1.32A 1nx9C-1lshA:
undetectable		 1nx9C-1lshA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 8 ARG A 679
TYR A 742
GLU A 545
SER A 649
 None
 1.33A 1nx9D-1lshA:
undetectable		 1nx9D-1lshA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 12 MET A 291
LEU A  46
ILE A 815
TYR A 281
THR A 120
 None
UPL  A2014 ( 4.2A)
UPL  A2014 ( 4.6A)
None
UPL  A2014 ( 3.9A)
 0.83A 1rx2A-1lshA:
undetectable		 1rx2A-1lshA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		3 / 3 SER A 939
GLY A 938
ARG A 331
 None
 0.62A 1t9wA-1lshA:
2.2		 1t9wA-1lshA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 6 LEU A 546
ALA A 514
ASP A 504
LYS A 543
 None
 1.21A 2dpzA-1lshA:
undetectable		 2dpzA-1lshA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 7 ARG A 806
GLY A 814
ILE A 815
PRO A 284
 None
None
UPL  A2014 ( 4.6A)
None
 0.70A 2fxdB-1lshA:
undetectable		 2fxdB-1lshA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 1lsh LIPOVITELLIN (LV-2)
(Ichthyomyzon
unicuspis) 		3 / 3 ARG B1505
ARG B1506
PRO B1504
 None
 0.98A 2wljA-1lshB:
undetectable		 2wljA-1lshB:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 4 LEU A 377
GLN A 402
THR A 398
THR A 418
 None
 1.47A 2zj0D-1lshA:
undetectable		 2zj0D-1lshA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 5 VAL A 365
GLN A 345
PHE A 335
ARG A 379
 None
 1.45A 3bjwE-1lshA:
0.0		 3bjwE-1lshA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 12 LEU A 480
GLY A 481
LEU A 433
ILE A 521
SER A 488
 None
 1.28A 3cjtK-1lshA:
undetectable		 3cjtK-1lshA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		3 / 3 CYH A 551
PHE A 554
PHE A 555
 None
 1.01A 3cr5X-1lshA:
undetectable		 3cr5X-1lshA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 7 THR A 159
VAL A 174
THR A 176
VAL A 213
 None
 0.32A 3em0B-1lshA:
3.3		 3em0B-1lshA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 6 PHE A 103
PHE A  18
HIS A  55
THR A  63
 None
PCA  A  17 ( 4.9A)
None
None
 1.20A 3lb3A-1lshA:
0.0		 3lb3A-1lshA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 11 ASP A 451
LEU A 453
VAL A 439
ALA A 483
ARG A 494
 None
 1.37A 3n23C-1lshA:
0.0		 3n23C-1lshA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 9 ARG A 519
ILE A 515
ASN A 520
ALA A 517
LEU A 496
 None
 1.46A 3o01A-1lshA:
0.0
3o01B-1lshA:
1.0		 3o01A-1lshA:
14.83
3o01B-1lshA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 10 ALA A 123
GLY A 814
ILE A 815
VAL A  69
LEU A  97
 None
None
UPL  A2014 ( 4.6A)
None
None
 0.99A 3ogpA-1lshA:
undetectable		 3ogpA-1lshA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
LIPOVITELLIN (LV-2)
(Ichthyomyzon
unicuspis) 		4 / 8 ALA B1366
GLN B1374
LEU A1020
SER A1059
 None
 0.89A 3qj7A-1lshB:
undetectable
3qj7D-1lshB:
undetectable		 3qj7A-1lshB:
23.96
3qj7D-1lshB:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 8 TYR A 216
GLU A 149
TYR A 160
LEU A 138
 None
 1.16A 3rqwC-1lshA:
undetectable
3rqwD-1lshA:
0.1		 3rqwC-1lshA:
14.34
3rqwD-1lshA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 8 GLU A 149
TYR A 160
LEU A 138
TYR A 216
 None
 1.14A 3rqwF-1lshA:
undetectable
3rqwJ-1lshA:
undetectable		 3rqwF-1lshA:
14.34
3rqwJ-1lshA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 12 GLY A 481
ALA A 479
HIS A 746
TYR A 194
GLU A 675
 None
None
PLD  A2007 ( 3.9A)
PLD  A2005 (-4.4A)
None
 1.42A 3s8pA-1lshA:
undetectable		 3s8pA-1lshA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 12 GLY A 481
ALA A 479
HIS A 746
TYR A 194
GLU A 675
 None
None
PLD  A2007 ( 3.9A)
PLD  A2005 (-4.4A)
None
 1.43A 3s8pB-1lshA:
0.0		 3s8pB-1lshA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 5 LEU A 454
LEU A 453
LEU A 438
SER A 437
 None
None
None
PLD  A2005 (-3.1A)
 1.02A 3vhuA-1lshA:
0.0		 3vhuA-1lshA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 12 GLY A 481
ALA A 479
HIS A 746
TYR A 194
GLU A 675
 None
None
PLD  A2007 ( 3.9A)
PLD  A2005 (-4.4A)
None
 1.48A 4bupA-1lshA:
undetectable		 4bupA-1lshA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 12 GLY A 481
ALA A 479
HIS A 746
TYR A 194
GLU A 675
 None
None
PLD  A2007 ( 3.9A)
PLD  A2005 (-4.4A)
None
 1.43A 4bupB-1lshA:
undetectable		 4bupB-1lshA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 8 SER A 591
ILE A 609
LYS A 610
ASP A 617
 None
 0.92A 4dtaB-1lshA:
undetectable		 4dtaB-1lshA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		3 / 3 LYS A 881
THR A 876
ILE A 288
 None
 0.93A 4e0fB-1lshA:
undetectable		 4e0fB-1lshA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 10 ALA A 412
LEU A 415
ILE A 394
ALA A 391
THR A 430
 None
None
None
None
PLD  A2005 ( 4.8A)
 1.11A 4j14A-1lshA:
undetectable		 4j14A-1lshA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 11 ILE A 126
MET A 291
LEU A  46
ILE A 815
THR A 120
 UPL  A2014 ( 4.7A)
None
UPL  A2014 ( 4.2A)
UPL  A2014 ( 4.6A)
UPL  A2014 ( 3.9A)
 1.07A 4p66A-1lshA:
undetectable		 4p66A-1lshA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 11 MET A 291
LEU A  46
ILE A 815
TYR A 281
THR A 120
 None
UPL  A2014 ( 4.2A)
UPL  A2014 ( 4.6A)
None
UPL  A2014 ( 3.9A)
 0.82A 4p66A-1lshA:
undetectable		 4p66A-1lshA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 12 MET A 291
LEU A  46
ILE A 815
TYR A 281
THR A 120
 None
UPL  A2014 ( 4.2A)
UPL  A2014 ( 4.6A)
None
UPL  A2014 ( 3.9A)
 0.93A 4pstA-1lshA:
undetectable		 4pstA-1lshA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 12 MET A 291
LEU A  46
ILE A 815
TYR A 281
THR A 120
 None
UPL  A2014 ( 4.2A)
UPL  A2014 ( 4.6A)
None
UPL  A2014 ( 3.9A)
 0.97A 4pthA-1lshA:
undetectable		 4pthA-1lshA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 5 TYR A  28
GLN A 254
SER A 252
ASP A 878
 UPL  A2014 (-4.6A)
None
None
UPL  A2014 (-4.2A)
 1.00A 4qtuB-1lshA:
undetectable		 4qtuB-1lshA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 12 GLY A 481
ALA A 479
HIS A 746
TYR A 194
GLU A 675
 None
None
PLD  A2007 ( 3.9A)
PLD  A2005 (-4.4A)
None
 1.40A 5cprB-1lshA:
undetectable		 5cprB-1lshA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 9 ILE A 813
GLY A  48
GLN A 236
LEU A  46
LEU A  86
 UPL  A2014 ( 4.9A)
UPL  A2014 (-3.7A)
None
UPL  A2014 ( 4.2A)
None
 1.20A 5fhzB-1lshA:
undetectable		 5fhzB-1lshA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 10 ILE A 813
GLY A  48
GLN A 236
LEU A  46
LEU A  86
 UPL  A2014 ( 4.9A)
UPL  A2014 (-3.7A)
None
UPL  A2014 ( 4.2A)
None
 1.10A 5fhzC-1lshA:
undetectable		 5fhzC-1lshA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 12 PHE A  74
GLY A 938
SER A 937
ARG A 331
GLY A 883
 None
 1.04A 5gwxA-1lshA:
undetectable		 5gwxA-1lshA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 12 PRO A 653
THR A 508
ILE A 647
GLN A 578
SER A 544
 UPL  A2032 ( 4.6A)
None
None
None
None
 1.26A 5hgcA-1lshA:
0.0		 5hgcA-1lshA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 8 ALA A 115
VAL A 101
LEU A  64
ASN A 125
 None
 0.80A 5nujA-1lshA:
1.7		 5nujA-1lshA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 7 GLY A 484
ILE A 489
GLN A 530
ASP A 525
 None
 1.17A 5vlmC-1lshA:
1.6		 5vlmC-1lshA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		3 / 3 ARG A 940
PHE A  83
LEU A  86
 None
 0.73A 5x1bC-1lshA:
0.0		 5x1bC-1lshA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 11 MET A 291
LEU A  46
ILE A 815
TYR A 281
THR A 120
 None
UPL  A2014 ( 4.2A)
UPL  A2014 ( 4.6A)
None
UPL  A2014 ( 3.9A)
 1.07A 5z6mA-1lshA:
undetectable		 5z6mA-1lshA:
8.86