SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lss'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 1lss TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A  30
ASP A  34
ASP A  51
 NAD  A1001 (-2.9A)
None
NAD  A1001 (-3.3A)
 0.64A 1eizA-1lssA:
8.2		 1eizA-1lssA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 1lss TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A  30
ASP A  34
ASP A  51
 NAD  A1001 (-2.9A)
None
NAD  A1001 (-3.3A)
 0.66A 1ej0A-1lssA:
8.5		 1ej0A-1lssA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 1lss TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A   7
ILE A  31
ASP A  32
ASP A  51
THR A  73
 NAD  A1001 (-3.1A)
NAD  A1001 (-4.1A)
None
NAD  A1001 (-3.3A)
NAD  A1001 (-3.5A)
 0.71A 3bwcA-1lssA:
6.1		 3bwcA-1lssA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1lss TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A  30
ASP A  34
ASP A  51
 NAD  A1001 (-2.9A)
None
NAD  A1001 (-3.3A)
 0.61A 3douA-1lssA:
8.0		 3douA-1lssA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1lss TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A   7
GLY A   9
ILE A  31
ASP A  32
ASP A  51
 NAD  A1001 (-3.1A)
NAD  A1001 (-3.5A)
NAD  A1001 (-4.1A)
None
NAD  A1001 (-3.3A)
 0.67A 3grvA-1lssA:
8.0		 3grvA-1lssA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 1lss TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		4 / 6 ALA A  16
ILE A  26
LEU A  28
GLU A  21
 None
 0.90A 3r9sC-1lssA:
undetectable		 3r9sC-1lssA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1lss TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		4 / 7 ASN A  79
ALA A  96
TYR A  69
ALA A   6
 None
 1.16A 3twpA-1lssA:
4.3		 3twpA-1lssA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1lss TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		4 / 5 ASN A  79
ALA A  96
TYR A  69
ALA A   6
 None
 1.12A 3twpD-1lssA:
4.0		 3twpD-1lssA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 1lss TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A  80
ASN A  79
LEU A  58
ILE A  29
 None
 1.02A 4okwA-1lssA:
undetectable		 4okwA-1lssA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 1lss TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A   7
ASP A  30
ILE A  31
ASP A  32
ASP A  51
 NAD  A1001 (-3.1A)
NAD  A1001 (-2.9A)
NAD  A1001 (-4.1A)
None
NAD  A1001 (-3.3A)
 0.64A 6bq4A-1lssA:
6.2		 6bq4A-1lssA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 1lss TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A   7
ASP A  30
ILE A  31
ASP A  32
ASP A  51
 NAD  A1001 (-3.1A)
NAD  A1001 (-2.9A)
NAD  A1001 (-4.1A)
None
NAD  A1001 (-3.3A)
 0.65A 6bq4B-1lssA:
6.3		 6bq4B-1lssA:
24.44