SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lt3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1lt3 HEAT-LABILE
ENTEROTOXIN
(Escherichia
coli) 		5 / 12 TYR A  86
TRP A 127
LEU A  22
GLU A 144
GLY A  20
 None
 0.96A 1etrH-1lt3A:
undetectable		 1etrH-1lt3A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1lt3 HEAT-LABILE
ENTEROTOXIN
(Escherichia
coli) 		4 / 7 ARG A   7
SER A  61
SER A  63
GLU A 112
 None
 0.90A 2c8aB-1lt3A:
undetectable		 2c8aB-1lt3A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1lt3 HEAT-LABILE
ENTEROTOXIN
(Escherichia
coli) 		4 / 6 ARG A   7
SER A  61
SER A  63
GLU A 112
 None
 0.92A 2c8aC-1lt3A:
undetectable		 2c8aC-1lt3A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1lt3 HEAT-LABILE
ENTEROTOXIN
(Escherichia
coli) 		4 / 7 ARG A   7
SER A  61
SER A  63
GLU A 112
 None
 0.97A 2c8aD-1lt3A:
undetectable		 2c8aD-1lt3A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1lt3 HEAT-LABILE
ENTEROTOXIN
(Escherichia
coli) 		4 / 7 ARG A 163
GLU A 159
PRO A 157
ALA A 156
 None
 1.47A 2ejgB-1lt3A:
undetectable		 2ejgB-1lt3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 1lt3 HEAT-LABILE
ENTEROTOXIN
(Escherichia
coli) 		4 / 7 TYR A 150
TYR A 210
TYR A  30
GLY A 117
 None
 1.22A 2ha4B-1lt3A:
undetectable		 2ha4B-1lt3A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 1lt3 HEAT-LABILE
ENTEROTOXIN
(Escherichia
coli) 		3 / 3 HIS A  27
MET A  23
MET A  37
 None
 1.37A 2vj1A-1lt3A:
0.0		 2vj1A-1lt3A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1lt3 HEAT-LABILE
ENTEROTOXIN
(Escherichia
coli) 		5 / 12 SER A 122
TYR A 214
VAL A  60
MET A  94
TYR A 149
 None
 1.41A 3dzyD-1lt3A:
undetectable		 3dzyD-1lt3A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1lt3 HEAT-LABILE
ENTEROTOXIN
(Escherichia
coli) 		5 / 8 GLY A 161
ALA A 158
GLY A 102
LEU A 101
VAL A 113
 None
 1.35A 3em6A-1lt3A:
undetectable		 3em6A-1lt3A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 1lt3 HEAT-LABILE
ENTEROTOXIN
(Escherichia
coli) 		4 / 6 ASN A  93
TYR A 149
TYR A 150
LEU A 153
 None
 1.23A 4f8yA-1lt3A:
undetectable
4f8yB-1lt3A:
undetectable		 4f8yA-1lt3A:
19.72
4f8yB-1lt3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 1lt3 HEAT-LABILE
ENTEROTOXIN
(Escherichia
coli) 		4 / 7 TYR A 149
TYR A 150
LEU A 153
ASN A  93
 None
 1.20A 4f8yC-1lt3A:
undetectable
4f8yD-1lt3A:
undetectable		 4f8yC-1lt3A:
19.72
4f8yD-1lt3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 1lt3 HEAT-LABILE
ENTEROTOXIN
(Escherichia
coli) 		4 / 7 TYR A 149
TYR A 150
LEU A 153
TYR A 210
 None
 1.18A 4f8yC-1lt3A:
undetectable
4f8yD-1lt3A:
undetectable		 4f8yC-1lt3A:
19.72
4f8yD-1lt3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1lt3 HEAT-LABILE
ENTEROTOXIN
(Escherichia
coli) 		4 / 5 TYR A  59
LEU A   5
ASP A  99
GLU A 112
 None
 1.27A 4nkvA-1lt3A:
0.0		 4nkvA-1lt3A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 1lt3 HEAT-LABILE
ENTEROTOXIN
(Escherichia
coli) 		4 / 7 ARG A   7
SER A  61
GLU A 110
GLU A 112
 None
 0.70A 4xzkA-1lt3A:
3.4		 4xzkA-1lt3A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1lt3 HEAT-LABILE
ENTEROTOXIN
(Escherichia
coli) 		4 / 8 ARG A 146
TYR A 121
ILE A  16
GLY A 118
 None
 0.89A 5nooD-1lt3A:
undetectable		 5nooD-1lt3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 1lt3 HEAT-LABILE
ENTEROTOXIN
(Escherichia
coli) 		4 / 6 PHE A  52
ARG A  11
ILE A  76
ASP A   9
 None
 1.45A 6dhbA-1lt3A:
0.0		 6dhbA-1lt3A:
18.33