SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lt8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLU A  34
GLY A  28
ALA A 250
PHE A  74
PHE A  63
 None
CBH  A 601 (-3.5A)
None
None
None
 1.32A 1nw3A-1lt8A:
undetectable		 1nw3A-1lt8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 VAL A  50
ALA A  49
HIS A  60
 None
 0.69A 1q23C-1lt8A:
0.0		 1q23C-1lt8A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 VAL A  50
ALA A  49
HIS A  60
 None
 0.71A 1q23H-1lt8A:
0.0		 1q23H-1lt8A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		4 / 4 THR A 184
GLY A  25
ASP A  26
ALA A 119
 None
 1.19A 1sg9A-1lt8A:
undetectable		 1sg9A-1lt8A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		4 / 4 LYS A 232
LEU A 291
LEU A 225
SER A 224
 None
 1.48A 1tz8D-1lt8A:
0.0		 1tz8D-1lt8A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 GLU A 166
GLU A 172
LEU A 145
 None
 0.77A 1v8bB-1lt8A:
undetectable		 1v8bB-1lt8A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 214
GLY A 298
GLY A 297
PHE A 302
ILE A 157
 None
 0.81A 2fxeA-1lt8A:
0.0		 2fxeA-1lt8A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		4 / 6 VAL A 343
TRP A 352
ARG A 278
TRP A 279
 None
 1.17A 2x2iA-1lt8A:
4.9		 2x2iA-1lt8A:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		4 / 8 TYR A 284
ILE A 281
ASP A 220
SER A 224
 None
None
CIT  A 701 (-2.8A)
None
 1.11A 2xytE-1lt8A:
0.0		 2xytE-1lt8A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		4 / 8 TYR A 284
ILE A 281
ASP A 220
SER A 224
 None
None
CIT  A 701 (-2.8A)
None
 1.10A 2xytH-1lt8A:
undetectable		 2xytH-1lt8A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 TYR A 284
ILE A 281
ASP A 220
SER A 224
 None
None
CIT  A 701 (-2.8A)
None
 1.12A 2xytI-1lt8A:
0.0		 2xytI-1lt8A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLN A  72
ASN A 216
ALA A 182
ALA A 119
ILE A 212
 CBH  A 601 ( 4.1A)
None
None
None
None
 1.07A 3ut5D-1lt8A:
3.2		 3ut5D-1lt8A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 297
TYR A 295
SER A  68
LEU A 249
GLY A 301
 None
 1.19A 4blvB-1lt8A:
undetectable		 4blvB-1lt8A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		4 / 6 ARG A 108
GLU A 113
LEU A  64
ASP A 112
 None
 1.41A 4cevE-1lt8A:
0.4
4cevF-1lt8A:
0.4		 4cevE-1lt8A:
21.09
4cevF-1lt8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 TYR A 305
HIS A 306
ARG A 278
 None
 1.03A 4e7bC-1lt8A:
0.4		 4e7bC-1lt8A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		4 / 5 PHE A 155
ILE A 157
GLY A 121
THR A  73
 None
 0.82A 4ejjC-1lt8A:
undetectable		 4ejjC-1lt8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 298
GLY A 297
ILE A 307
VAL A 275
ILE A 281
 None
 1.03A 4fglA-1lt8A:
undetectable
4fglB-1lt8A:
undetectable		 4fglA-1lt8A:
19.95
4fglB-1lt8A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 10 ALA A 116
VAL A 153
ILE A 157
THR A  75
ALA A 103
 None
 0.95A 4j14A-1lt8A:
undetectable		 4j14A-1lt8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		6 / 12 ILE A  13
GLY A 209
ALA A 210
SER A 211
LEU A  14
LEU A  17
 None
 1.24A 4o1zA-1lt8A:
undetectable		 4o1zA-1lt8A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		6 / 12 MET A 245
ILE A  13
GLY A 209
ALA A 210
LEU A  14
LEU A  17
 None
 1.41A 4o1zA-1lt8A:
undetectable		 4o1zA-1lt8A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 9 PRO A 221
ILE A 296
GLY A 297
GLY A 298
ALA A 285
 None
 0.87A 5o96A-1lt8A:
3.1
5o96B-1lt8A:
2.2		 5o96A-1lt8A:
22.76
5o96B-1lt8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 ALA A 103
PHE A 148
GLN A 144
 None
 0.82A 6eceA-1lt8A:
2.6		 6eceA-1lt8A:
22.69