SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ltd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 375
ASN A 157
GLY A 374
VAL A 387
 None
None
FMN  A 570 (-3.3A)
None
 0.86A 1dbbH-1ltdA:
undetectable
1dbbL-1ltdA:
undetectable		 1dbbH-1ltdA:
17.79
1dbbL-1ltdA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 419
TYR A 161
VAL A 429
GLY A 428
ALA A 426
 None
 1.25A 1pxxD-1ltdA:
undetectable		 1pxxD-1ltdA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 127
TYR A 126
GLU A 457
 None
 0.80A 1vm1A-1ltdA:
undetectable		 1vm1A-1ltdA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 7 HIS A  66
TYR A  74
HIS A  43
PRO A  44
 HEM  A 560 (-3.3A)
None
HEM  A 560 (-3.3A)
HEM  A 560 (-4.3A)
 1.12A 2ombC-1ltdA:
undetectable
2ombD-1ltdA:
undetectable		 2ombC-1ltdA:
17.49
2ombD-1ltdA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 7 TYR A  74
HIS A  43
PRO A  44
HIS A  66
 None
HEM  A 560 (-3.3A)
HEM  A 560 (-4.3A)
HEM  A 560 (-3.3A)
 1.09A 2ombC-1ltdA:
undetectable
2ombD-1ltdA:
undetectable		 2ombC-1ltdA:
17.49
2ombD-1ltdA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 12 MET A 462
ILE A 458
LEU A 419
THR A 221
VAL A 223
 None
 1.15A 3a51C-1ltdA:
0.0		 3a51C-1ltdA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 410
HIS A 158
ILE A 385
VAL A 408
VAL A 429
 FMN  A 570 (-3.5A)
None
None
None
None
 1.12A 3fhjA-1ltdA:
undetectable		 3fhjA-1ltdA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 410
HIS A 158
ILE A 385
VAL A 408
VAL A 429
 FMN  A 570 (-3.5A)
None
None
None
None
 1.13A 3fhjB-1ltdA:
undetectable		 3fhjB-1ltdA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 410
HIS A 158
ILE A 385
VAL A 408
VAL A 429
 FMN  A 570 (-3.5A)
None
None
None
None
 1.12A 3fhjC-1ltdA:
undetectable		 3fhjC-1ltdA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 410
HIS A 158
ILE A 385
VAL A 408
VAL A 429
 FMN  A 570 (-3.5A)
None
None
None
None
 1.12A 3fhjD-1ltdA:
undetectable		 3fhjD-1ltdA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 410
HIS A 158
ILE A 385
VAL A 408
VAL A 429
 FMN  A 570 (-3.5A)
None
None
None
None
 1.12A 3fhjE-1ltdA:
undetectable		 3fhjE-1ltdA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 410
HIS A 158
ILE A 385
VAL A 408
VAL A 429
 FMN  A 570 (-3.5A)
None
None
None
None
 1.12A 3fhjF-1ltdA:
undetectable		 3fhjF-1ltdA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 281
ILE A 346
MET A 183
ARG A 353
 None
 1.15A 3oezA-1ltdA:
0.0		 3oezA-1ltdA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 154
ARG A 433
GLU A 129
 None
FMN  A 570 (-3.8A)
None
 1.14A 3qf1A-1ltdA:
0.0		 3qf1A-1ltdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 7 THR A 153
GLY A 374
ASN A 372
GLY A 287
 None
FMN  A 570 (-3.3A)
None
None
 0.86A 3tajA-1ltdA:
undetectable		 3tajA-1ltdA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 442
GLU A 129
TYR A 126
 None
 1.02A 3ug8A-1ltdA:
11.9		 3ug8A-1ltdA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 8 THR A 137
TYR A 437
ARG A 108
LEU A 112
 None
 1.26A 3wipG-1ltdA:
0.0
3wipH-1ltdA:
0.0		 3wipG-1ltdA:
17.95
3wipH-1ltdA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 251
THR A 229
GLU A 236
 None
 0.67A 4df3A-1ltdA:
0.1		 4df3A-1ltdA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 251
THR A 229
GLU A 236
 None
 0.69A 4df3B-1ltdA:
0.1		 4df3B-1ltdA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 6 THR A 153
GLY A 374
ASN A 372
GLY A 287
 None
FMN  A 570 (-3.3A)
None
None
 0.88A 4fjpA-1ltdA:
undetectable		 4fjpA-1ltdA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 8 ASN A  69
ALA A  67
SER A 234
TYR A 251
 None
 1.02A 4ijiF-1ltdA:
undetectable		 4ijiF-1ltdA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 8 TYR A  97
HIS A  66
LEU A 202
LEU A 199
 HEM  A 560 (-4.0A)
HEM  A 560 (-3.3A)
None
HEM  A 560 (-4.1A)
 1.09A 4jtrA-1ltdA:
5.2		 4jtrA-1ltdA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 8 ALA A 438
ASP A 456
ILE A 453
ASP A 127
ILE A 123
 None
 1.46A 4kttB-1ltdA:
undetectable		 4kttB-1ltdA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 374
ASP A 409
ASN A 157
HIS A 158
TYR A 161
 FMN  A 570 (-3.3A)
FMN  A 570 (-2.6A)
None
None
None
 1.20A 4ypuA-1ltdA:
undetectable		 4ypuA-1ltdA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		3 / 3 PHE A  39
ILE A  50
ASP A  24
 HEM  A 560 (-4.2A)
HEM  A 560 (-4.6A)
None
 0.73A 5cswA-1ltdA:
undetectable		 5cswA-1ltdA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 164
MET A 462
ASP A 417
 None
 0.84A 5h2uA-1ltdA:
undetectable		 5h2uA-1ltdA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 410
GLY A 411
ALA A 160
ASN A 372
GLY A 375
 FMN  A 570 (-3.5A)
FMN  A 570 (-3.9A)
None
None
None
 1.01A 5kb5A-1ltdA:
undetectable		 5kb5A-1ltdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 412
ARG A 413
PRO A 434
GLY A 432
 None
FMN  A 570 (-3.9A)
None
FMN  A 570 (-3.8A)
 0.94A 5x80A-1ltdA:
0.4
5x80B-1ltdA:
0.0		 5x80A-1ltdA:
16.85
5x80B-1ltdA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 412
ARG A 413
PRO A 434
GLY A 432
 None
FMN  A 570 (-3.9A)
None
FMN  A 570 (-3.8A)
 0.99A 5x80C-1ltdA:
undetectable
5x80D-1ltdA:
undetectable		 5x80C-1ltdA:
16.85
5x80D-1ltdA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 5 PRO A 434
GLY A 432
VAL A 412
ARG A 413
 None
FMN  A 570 (-3.8A)
None
FMN  A 570 (-3.9A)
 0.98A 5x80C-1ltdA:
0.0
5x80D-1ltdA:
0.0		 5x80C-1ltdA:
16.85
5x80D-1ltdA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 369
LEU A 370
SER A 371
GLY A 428
GLY A 432
 None
None
FMN  A 570 (-3.5A)
None
FMN  A 570 (-3.8A)
 1.13A 6eu9B-1ltdA:
0.0		 6eu9B-1ltdA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 136
ALA A 132
SER A 145
THR A 197
 None
None
None
FMN  A 570 ( 4.8A)
 1.00A 6f88A-1ltdA:
undetectable		 6f88A-1ltdA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1ltd FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 227
GLN A 252
THR A 280
VAL A 281
 None
FMN  A 570 (-3.0A)
FMN  A 570 (-3.3A)
None
 0.96A 6fbvC-1ltdA:
undetectable		 6fbvC-1ltdA:
18.86