SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lth'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
5 / 12 MET T  52
ALA T  26
LEU T  22
LEU T  37
ILE T  35
None
1.05A 1bsxA-1lthT:
0.0
1bsxA-1lthT:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
5 / 12 MET T  52
ALA T  26
LEU T  22
LEU T  37
ILE T  35
None
1.05A 1bsxB-1lthT:
0.0
1bsxB-1lthT:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
5 / 9 GLY T  14
ASP T  39
ILE T  40
ALA T  83
ILE T 103
NAD  T 321 ( 3.8A)
NAD  T 321 ( 2.8A)
NAD  T 321 ( 4.0A)
NAD  T 321 ( 3.5A)
NAD  T 321 ( 4.4A)
0.38A 1cetA-1lthT:
37.8
1cetA-1lthT:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
4 / 7 LYS T 223
LEU T 157
SER T 154
THR T 150
None
0.99A 1dvxA-1lthT:
undetectable
1dvxA-1lthT:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
4 / 7 LYS T 223
LEU T 157
SER T 154
THR T 150
None
0.99A 1dvxB-1lthT:
undetectable
1dvxB-1lthT:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
5 / 10 ALA T 177
LEU T 265
SER T 272
LEU T 310
ALA T 307
None
1.27A 1g5yC-1lthT:
undetectable
1g5yC-1lthT:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
5 / 11 VAL T 127
GLU T 184
ILE T 240
VAL T  80
MET T 121
None
None
NAD  T 321 ( 3.8A)
None
None
1.20A 1gx9A-1lthT:
undetectable
1gx9A-1lthT:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
5 / 12 LEU T 122
ALA T 134
LEU T 137
PRO T 109
ILE T 103
None
None
None
None
NAD  T 321 ( 4.4A)
1.27A 1mx8A-1lthT:
undetectable
1mx8A-1lthT:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
4 / 7 LEU T  94
VAL T  97
GLY T  98
VAL T 133
None
0.61A 1p2yA-1lthT:
undetectable
1p2yA-1lthT:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
4 / 6 VAL T 251
VAL T  36
ILE T  13
ILE T  72
None
0.64A 1uwhA-1lthT:
undetectable
1uwhA-1lthT:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
4 / 6 VAL T 251
VAL T  36
ILE T  13
ILE T  72
None
0.63A 1uwhB-1lthT:
undetectable
1uwhB-1lthT:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
5 / 10 VAL T  80
ILE T 247
GLY T 244
ILE T  31
LEU T  10
None
0.90A 1z11C-1lthT:
0.0
1z11C-1lthT:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
5 / 10 VAL T  80
ILE T 247
GLY T 244
ILE T  31
LEU T  10
None
0.95A 1z11D-1lthT:
0.0
1z11D-1lthT:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
4 / 6 LEU T 152
ASN T 151
LEU T  22
ILE T 248
None
0.83A 1z95A-1lthT:
undetectable
1z95A-1lthT:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
5 / 12 MET T  52
ALA T  26
LEU T  22
LEU T  37
ILE T  35
None
1.11A 2h77A-1lthT:
0.0
2h77A-1lthT:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
3 / 3 THR T 280
ASP T 128
SER T 306
None
0.84A 2nxeA-1lthT:
6.5
2nxeA-1lthT:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
3 / 3 THR T 280
ASP T 128
SER T 306
None
0.80A 2nxeB-1lthT:
6.6
2nxeB-1lthT:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
4 / 4 VAL T 172
ARG T 156
ILE T 176
THR T 165
None
1.38A 3cl9A-1lthT:
undetectable
3cl9A-1lthT:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
4 / 7 LEU T 265
ASP T 267
SER T 263
THR T 280
None
1.33A 3dzgB-1lthT:
2.9
3dzgB-1lthT:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
3 / 3 PRO T 209
LEU T 210
GLN T 164
None
0.67A 3hznG-1lthT:
0.0
3hznH-1lthT:
0.0
3hznG-1lthT:
22.08
3hznH-1lthT:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
3 / 3 ASP T  51
PHE T  24
SER T  56
None
0.69A 3i5uB-1lthT:
7.3
3i5uB-1lthT:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
5 / 11 ARG T 284
LEU T 252
ALA T  26
VAL T  36
ILE T 248
None
1.30A 3oxxB-1lthT:
0.0
3oxxB-1lthT:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
3 / 3 ASP T 128
GLU T 184
GLY T 178
None
0.69A 3w9tA-1lthT:
0.0
3w9tA-1lthT:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
5 / 12 MET T  52
ALA T  26
LEU T  22
LEU T  37
ILE T  35
None
1.14A 4lnwA-1lthT:
0.0
4lnwA-1lthT:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
5 / 12 MET T  52
ALA T  26
LEU T  22
LEU T  37
ILE T  35
None
1.12A 4lnxA-1lthT:
0.0
4lnxA-1lthT:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
4 / 7 LEU T 152
ASN T 151
LEU T  22
ILE T 248
None
0.81A 4okwA-1lthT:
undetectable
4okwA-1lthT:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
3 / 3 LEU T 122
ASP T 128
ILE T 119
None
0.71A 4xi3D-1lthT:
undetectable
4xi3D-1lthT:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
4 / 8 VAL T 251
VAL T  36
ILE T  13
ILE T  72
None
0.61A 5hi2A-1lthT:
undetectable
5hi2A-1lthT:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
5 / 12 GLY T  66
ASP T  39
ASP T  69
ALA T  11
CYH T  73
None
NAD  T 321 ( 2.8A)
None
None
None
0.82A 6bq4A-1lthT:
5.0
6bq4A-1lthT:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
5 / 12 GLY T  66
ASP T  39
ASP T  69
ALA T  11
CYH T  73
None
NAD  T 321 ( 2.8A)
None
None
None
0.85A 6bq4B-1lthT:
5.0
6bq4B-1lthT:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
3 / 3 LEU T  50
ASP T  68
ILE T  72
None
0.54A 6dh0B-1lthT:
undetectable
6dh0B-1lthT:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum)
5 / 11 VAL T 127
THR T 150
THR T 280
ILE T 291
VAL T 278
None
1.46A 6hcoA-1lthT:
0.0
6hcoB-1lthT:
0.0
6hcoA-1lthT:
19.70
6hcoB-1lthT:
19.70