SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ltl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 1ltl DNA REPLICATION
INITIATOR
(CDC21/CDC54)
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 ALA A  68
ILE A  39
VAL A  41
PHE A  88
 None
 0.61A 2cizA-1ltlA:
undetectable		 2cizA-1ltlA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1ltl DNA REPLICATION
INITIATOR
(CDC21/CDC54)
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 SER A 144
PRO A 151
VAL A 141
GLN A 143
ILE A 148
 None
 1.48A 2o7oA-1ltlA:
0.9		 2o7oA-1ltlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 1ltl DNA REPLICATION
INITIATOR
(CDC21/CDC54)
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 THR A 208
ASP A 205
GLU A 120
 None
 0.73A 3qowA-1ltlA:
undetectable		 3qowA-1ltlA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 1ltl DNA REPLICATION
INITIATOR
(CDC21/CDC54)
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ARG A  37
GLU A 170
TYR A  33
 None
 0.92A 4r29D-1ltlA:
0.0		 4r29D-1ltlA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 1ltl DNA REPLICATION
INITIATOR
(CDC21/CDC54)
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ASP A  55
SER A  92
TYR A  43
 None
 0.88A 5glmA-1ltlA:
0.0		 5glmA-1ltlA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1ltl DNA REPLICATION
INITIATOR
(CDC21/CDC54)
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 THR A 176
VAL A 198
TYR A 235
LEU A 172
ARG A 124
 None
 1.39A 6ak3A-1ltlA:
0.0		 6ak3A-1ltlA:
15.25