SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ltm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		3 / 3 ALA A 113
VAL A 319
TRP A 114
 None
 0.53A 1bdwA-1ltmA:
undetectable
1bdwB-1ltmA:
undetectable		 1bdwA-1ltmA:
3.95
1bdwB-1ltmA:
3.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		4 / 4 GLY A 268
VAL A 266
TRP A 145
GLY A 149
 None
 0.99A 1ng8A-1ltmA:
undetectable		 1ng8A-1ltmA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		4 / 4 GLY A 268
VAL A 266
TRP A 145
GLY A 149
 None
 0.99A 1ng8B-1ltmA:
undetectable		 1ng8B-1ltmA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		3 / 3 ARG A 167
ILE A 159
TRP A 165
 None
 1.14A 1nodB-1ltmA:
undetectable		 1nodB-1ltmA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		3 / 3 ARG A 167
ILE A 159
TRP A 165
 None
 1.19A 1qomA-1ltmA:
0.0		 1qomA-1ltmA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 11 ALA A 220
ALA A 218
GLY A 219
PHE A 192
ARG A 188
 BCN  A 401 ( 3.9A)
EDO  A 402 ( 3.8A)
None
None
EDO  A 402 (-3.2A)
 1.50A 2xfsB-1ltmA:
0.0		 2xfsB-1ltmA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 11 ALA A 218
GLY A 219
ALA A 220
MET A 227
ARG A 188
 EDO  A 402 ( 3.8A)
None
BCN  A 401 ( 3.9A)
BCN  A 401 (-4.0A)
EDO  A 402 (-3.2A)
 1.49A 2xh9A-1ltmA:
undetectable		 2xh9A-1ltmA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 12 ALA A 218
SER A 193
ALA A  60
PHE A  63
PHE A 192
 EDO  A 402 ( 3.8A)
None
None
None
None
 1.09A 2zifB-1ltmA:
undetectable		 2zifB-1ltmA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		4 / 4 LEU A 315
ALA A 272
VAL A 271
PRO A 330
 None
 1.05A 3gv1B-1ltmA:
undetectable		 3gv1B-1ltmA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		3 / 3 ARG A 164
ILE A 159
TRP A 165
 None
 1.14A 3nw2A-1ltmA:
0.0		 3nw2A-1ltmA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		3 / 3 ARG A 164
ILE A 159
TRP A 165
 None
 1.14A 3nw2B-1ltmA:
undetectable		 3nw2B-1ltmA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		4 / 6 GLY A 170
VAL A 168
GLY A 224
TYR A 223
 None
 0.87A 4dxuA-1ltmA:
undetectable		 4dxuA-1ltmA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		4 / 6 GLN A  61
ILE A  64
PHE A  63
PHE A 183
 None
 1.18A 4fgkA-1ltmA:
undetectable		 4fgkA-1ltmA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		3 / 3 ARG A 337
HIS A 340
TYR A 333
 None
 1.02A 4fu8A-1ltmA:
0.0		 4fu8A-1ltmA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		3 / 3 ARG A 337
HIS A 340
TYR A 333
 None
 1.05A 4fu9A-1ltmA:
undetectable		 4fu9A-1ltmA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		3 / 3 ARG A 118
TRP A 114
ILE A 122
 None
 1.08A 4mwxA-1ltmA:
undetectable		 4mwxA-1ltmA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 11 PRO A 228
LEU A 196
ILE A  81
LEU A  78
ILE A 174
 None
 1.05A 4odrA-1ltmA:
undetectable
4odrB-1ltmA:
undetectable		 4odrA-1ltmA:
15.46
4odrB-1ltmA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 9 LEU A  94
ASP A  89
LEU A  88
LEU A 181
ALA A 177
 None
 1.13A 5dqfA-1ltmA:
undetectable		 5dqfA-1ltmA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 12 GLY A 170
GLY A 224
GLY A 215
VAL A 256
ILE A 159
 None
 0.95A 5ehgC-1ltmA:
undetectable		 5ehgC-1ltmA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 12 GLY A 170
GLY A 224
GLY A 215
VAL A 256
ILE A 159
 None
 0.97A 5eiwA-1ltmA:
undetectable		 5eiwA-1ltmA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 12 ALA A 220
ALA A 218
PHE A 217
PHE A 192
TYR A 191
 BCN  A 401 ( 3.9A)
EDO  A 402 ( 3.8A)
None
None
EDO  A 402 (-4.9A)
 1.14A 5k9dA-1ltmA:
undetectable		 5k9dA-1ltmA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 12 GLY A 170
GLY A 224
GLY A 215
VAL A 256
ILE A 159
 None
 0.96A 5kqrA-1ltmA:
undetectable		 5kqrA-1ltmA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 12 GLY A 224
GLY A 222
GLY A 170
VAL A 256
ILE A 159
 None
 0.95A 5kqrA-1ltmA:
undetectable		 5kqrA-1ltmA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 12 GLY A 170
GLY A 224
GLY A 215
VAL A 256
ILE A 159
 None
 0.95A 5vimA-1ltmA:
undetectable		 5vimA-1ltmA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 12 GLY A 224
GLY A 222
GLY A 170
VAL A 256
ILE A 159
 None
 0.97A 5vimA-1ltmA:
undetectable		 5vimA-1ltmA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 12 GLY A 224
GLY A 222
GLY A 170
VAL A 256
ILE A 159
 None
 0.96A 5vimB-1ltmA:
undetectable		 5vimB-1ltmA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 12 GLY A 170
GLY A 224
GLY A 215
VAL A 256
ILE A 159
 None
 0.95A 5wz1A-1ltmA:
undetectable		 5wz1A-1ltmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 12 GLY A 170
GLY A 224
GLY A 215
VAL A 256
ILE A 159
 None
 0.98A 5wz1C-1ltmA:
undetectable		 5wz1C-1ltmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 12 GLY A 170
GLY A 224
GLY A 215
VAL A 256
ILE A 159
 None
 0.96A 5wz1D-1ltmA:
undetectable		 5wz1D-1ltmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 12 GLY A 170
GLY A 224
GLY A 215
VAL A 256
ILE A 159
 None
 0.99A 5wz1E-1ltmA:
undetectable		 5wz1E-1ltmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 12 GLY A 170
GLY A 224
GLY A 215
VAL A 256
ILE A 159
 None
 0.96A 5wz1F-1ltmA:
undetectable		 5wz1F-1ltmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 12 GLY A 170
GLY A 224
GLY A 215
VAL A 256
ILE A 159
 None
 0.93A 5wz1G-1ltmA:
undetectable		 5wz1G-1ltmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 12 GLY A 170
GLY A 224
GLY A 215
VAL A 256
ILE A 159
 None
 0.97A 5wz1H-1ltmA:
undetectable		 5wz1H-1ltmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE
(Escherichia
coli) 		5 / 12 PHE A 199
ASP A 176
ALA A 179
ILE A  81
LEU A 200
 None
 0.91A 6dwnD-1ltmA:
undetectable		 6dwnD-1ltmA:
15.19