SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ltz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 TYR A 197
LEU A 187
LEU A  55
SER A 208
 None
 1.08A 1i7zA-1ltzA:
undetectable		 1i7zA-1ltzA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 7 VAL A  98
LEU A 101
PHE A 107
ALA A 176
 None
HBI  A 500 ( 4.5A)
HBI  A 500 (-3.8A)
HBI  A 500 ( 4.2A)
 0.84A 1j8uA-1ltzA:
28.1		 1j8uA-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
HIS A 143
TYR A 179
TRP A 180
GLU A 184
 None
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
None
FE  A 400 (-1.9A)
 0.96A 1kw0A-1ltzA:
26.7		 1kw0A-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
LEU A 101
HIS A 143
TYR A 179
GLU A 184
 None
HBI  A 500 ( 4.5A)
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 0.71A 1kw0A-1ltzA:
26.7		 1kw0A-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
LEU A 101
PHE A 107
THR A 119
GLU A 184
 None
HBI  A 500 ( 4.5A)
HBI  A 500 (-3.8A)
None
FE  A 400 (-1.9A)
 1.09A 1kw0A-1ltzA:
26.7		 1kw0A-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
LEU A 101
PHE A 107
TYR A 179
GLU A 184
 None
HBI  A 500 ( 4.5A)
HBI  A 500 (-3.8A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 1.10A 1kw0A-1ltzA:
26.7		 1kw0A-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
LEU A 101
THR A 119
HIS A 143
GLU A 184
 None
HBI  A 500 ( 4.5A)
None
FE  A 400 (-3.4A)
FE  A 400 (-1.9A)
 0.61A 1kw0A-1ltzA:
26.7		 1kw0A-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
PHE A 107
THR A 119
TRP A 180
GLU A 184
 None
HBI  A 500 (-3.8A)
None
None
FE  A 400 (-1.9A)
 1.16A 1kw0A-1ltzA:
26.7		 1kw0A-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
PHE A 107
TYR A 179
TRP A 180
GLU A 184
 None
HBI  A 500 (-3.8A)
HBI  A 500 ( 4.0A)
None
FE  A 400 (-1.9A)
 1.24A 1kw0A-1ltzA:
26.7		 1kw0A-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
THR A 119
HIS A 143
TRP A 180
GLU A 184
 None
None
FE  A 400 (-3.4A)
None
FE  A 400 (-1.9A)
 0.74A 1kw0A-1ltzA:
26.7		 1kw0A-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 LEU A 101
LEU A 111
HIS A 143
TYR A 179
GLU A 184
 HBI  A 500 ( 4.5A)
None
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 1.47A 1mmkA-1ltzA:
26.6		 1mmkA-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
HIS A 143
TYR A 179
TRP A 180
GLU A 184
 None
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
None
FE  A 400 (-1.9A)
 0.94A 1mmkA-1ltzA:
26.6		 1mmkA-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
LEU A 101
HIS A 143
TYR A 179
GLU A 184
 None
HBI  A 500 ( 4.5A)
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 0.70A 1mmkA-1ltzA:
26.6		 1mmkA-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
LEU A 101
PHE A 107
TYR A 179
GLU A 184
 None
HBI  A 500 ( 4.5A)
HBI  A 500 (-3.8A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 1.05A 1mmkA-1ltzA:
26.6		 1mmkA-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
PHE A 107
TYR A 179
TRP A 180
GLU A 184
 None
HBI  A 500 (-3.8A)
HBI  A 500 ( 4.0A)
None
FE  A 400 (-1.9A)
 1.21A 1mmkA-1ltzA:
26.6		 1mmkA-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		6 / 11 VAL A  98
LEU A 101
PHE A 107
THR A 119
TYR A 179
GLU A 184
 None
HBI  A 500 ( 4.5A)
HBI  A 500 (-3.8A)
None
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 1.05A 1mmtA-1ltzA:
26.7		 1mmtA-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		6 / 11 VAL A  98
LEU A 101
THR A 119
HIS A 143
TYR A 179
GLU A 184
 None
HBI  A 500 ( 4.5A)
None
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 0.72A 1mmtA-1ltzA:
26.7		 1mmtA-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.05A 1p7lC-1ltzA:
undetectable		 1p7lC-1ltzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.06A 1p7lD-1ltzA:
undetectable		 1p7lD-1ltzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A 118
LEU A 147
VAL A 183
ASP A 139
GLY A 142
 None
None
None
HBI  A 500 ( 4.9A)
None
 1.04A 1r9oA-1ltzA:
0.0		 1r9oA-1ltzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.02A 1rg9A-1ltzA:
undetectable		 1rg9A-1ltzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.03A 1rg9B-1ltzA:
undetectable		 1rg9B-1ltzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.04A 1rg9C-1ltzA:
undetectable		 1rg9C-1ltzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.04A 1rg9D-1ltzA:
undetectable		 1rg9D-1ltzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.97A 2obvA-1ltzA:
undetectable		 2obvA-1ltzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.99A 2p02A-1ltzA:
undetectable		 2p02A-1ltzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 9 TYR A 262
LEU A 175
ALA A 166
LEU A 224
MET A 228
 CL  A 401 ( 4.9A)
None
CL  A 401 ( 4.9A)
None
None
 1.19A 2qo5A-1ltzA:
0.0		 2qo5A-1ltzA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 9 TYR A 262
VAL A 164
ALA A 166
LEU A 224
MET A 228
 CL  A 401 ( 4.9A)
None
CL  A 401 ( 4.9A)
None
None
 1.34A 2qo5A-1ltzA:
0.0		 2qo5A-1ltzA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
TRP A 180
HIS A 143
ASP A 139
 FE  A 400 (-3.3A)
None
FE  A 400 (-3.4A)
HBI  A 500 ( 4.9A)
 1.09A 2xadA-1ltzA:
undetectable		 2xadA-1ltzA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
TRP A 180
HIS A 143
ASP A 139
 FE  A 400 (-3.3A)
None
FE  A 400 (-3.4A)
HBI  A 500 ( 4.9A)
 1.12A 2xadB-1ltzA:
undetectable		 2xadB-1ltzA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 TYR A 179
LEU A 250
TYR A 155
PHE A 152
 HBI  A 500 ( 4.0A)
None
None
None
 1.33A 3po7A-1ltzA:
undetectable		 3po7A-1ltzA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_B_ZONB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 9 TYR A 179
LEU A 250
ILE A 227
PHE A 152
TYR A 197
 HBI  A 500 ( 4.0A)
None
None
None
None
 1.41A 3po7B-1ltzA:
0.0		 3po7B-1ltzA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		3 / 3 ARG A  58
ARG A 195
ILE A 209
 None
 0.83A 4b7qC-1ltzA:
undetectable		 4b7qC-1ltzA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.98A 4kttA-1ltzA:
undetectable		 4kttA-1ltzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.98A 4kttC-1ltzA:
undetectable		 4kttC-1ltzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.89A 4ndnA-1ltzA:
undetectable		 4ndnA-1ltzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 7 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.97A 4ndnC-1ltzA:
undetectable		 4ndnC-1ltzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 LEU A 212
ASN A 189
ILE A 188
GLY A 193
ALA A 192
 None
 1.15A 4nkvC-1ltzA:
0.0		 4nkvC-1ltzA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 7 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.02A 4odjA-1ltzA:
undetectable		 4odjA-1ltzA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 6 LEU A 101
PHE A 107
TYR A 179
GLU A 184
 HBI  A 500 ( 4.5A)
HBI  A 500 (-3.8A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 0.94A 4pahA-1ltzA:
28.0		 4pahA-1ltzA:
28.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 6 PHE A 107
HIS A 138
HIS A 143
TYR A 179
GLU A 184
 HBI  A 500 (-3.8A)
FE  A 400 (-3.3A)
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 0.55A 4pahA-1ltzA:
28.0		 4pahA-1ltzA:
28.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		3 / 3 VAL A 136
LEU A 140
VAL A 118
 None
 0.52A 4wq4A-1ltzA:
undetectable		 4wq4A-1ltzA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		3 / 5 GLY A 142
GLY A 200
GLU A 184
 None
None
FE  A 400 (-1.9A)
 0.43A 4z2eA-1ltzA:
undetectable
4z2eD-1ltzA:
undetectable		 4z2eA-1ltzA:
19.84
4z2eD-1ltzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.97A 5a1iA-1ltzA:
undetectable		 5a1iA-1ltzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 7 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.97A 5a1iA-1ltzA:
undetectable		 5a1iA-1ltzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 6 ILE A 234
PHE A 185
THR A 119
TRP A 121
 None
 1.37A 5g08A-1ltzA:
0.0		 5g08A-1ltzA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 7 TYR A 197
GLN A 238
HIS A 138
TYR A 155
 None
None
FE  A 400 (-3.3A)
None
 1.38A 5ov9B-1ltzA:
undetectable		 5ov9B-1ltzA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 4 HIS A 138
HIS A 143
TYR A 179
GLU A 184
 FE  A 400 (-3.3A)
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 0.48A 5pahA-1ltzA:
28.0		 5pahA-1ltzA:
28.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.05A 5t8sB-1ltzA:
undetectable		 5t8sB-1ltzA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 10 LEU A 146
GLY A  66
VAL A  72
TYR A  48
HIS A 143
 None
None
None
None
FE  A 400 (-3.4A)
 1.45A 5tqrB-1ltzA:
undetectable		 5tqrB-1ltzA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		3 / 3 LYS A  86
LEU A 140
ASP A  73
 None
 0.62A 5zv2A-1ltzA:
undetectable		 5zv2A-1ltzA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 ASP A 139
ARG A 123
GLY A 200
GLY A 142
PHE A 185
 HBI  A 500 ( 4.9A)
None
None
None
None
 1.31A 6clxA-1ltzA:
undetectable		 6clxA-1ltzA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 LEU A  47
GLN A  51
VAL A 136
LEU A 122
 None
 0.85A 6czmD-1ltzA:
undetectable
6czmF-1ltzA:
undetectable		 6czmD-1ltzA:
21.19
6czmF-1ltzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.03A 6fbnB-1ltzA:
undetectable		 6fbnB-1ltzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.98A 6fboA-1ltzA:
undetectable		 6fboA-1ltzA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.95A 6fcbA-1ltzA:
undetectable		 6fcbA-1ltzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.99A 6fcdA-1ltzA:
undetectable		 6fcdA-1ltzA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 7 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.96A 6g6rA-1ltzA:
undetectable		 6g6rA-1ltzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 6 LEU A 101
HIS A 138
HIS A 143
TYR A 179
 HBI  A 500 ( 4.5A)
FE  A 400 (-3.3A)
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
 0.80A 6pahA-1ltzA:
27.9		 6pahA-1ltzA:
28.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 6 PRO A 134
HIS A 138
HIS A 143
TYR A 179
GLU A 184
 None
FE  A 400 (-3.3A)
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 0.51A 6pahA-1ltzA:
27.9		 6pahA-1ltzA:
28.31