SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lua'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		4 / 6 ALA A 104
SER A  91
ARG A 167
LEU A 139
 None
 1.08A 1gahA-1luaA:
undetectable		 1gahA-1luaA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		4 / 6 THR A 102
ASN A 100
LEU A  94
ASP A  95
 NAP  A 456 (-3.7A)
None
None
None
 1.31A 1mxdA-1luaA:
undetectable		 1mxdA-1luaA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		5 / 12 GLY A  23
GLY A  27
VAL A  17
ASP A  19
GLN A   8
 None
 1.27A 1n2xA-1luaA:
8.8		 1n2xA-1luaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		4 / 7 ILE A 264
LEU A 267
PHE A 268
THR A  32
 None
 1.06A 2zxwN-1luaA:
0.0
2zxwW-1luaA:
undetectable		 2zxwN-1luaA:
19.12
2zxwW-1luaA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		4 / 7 ILE A 264
LEU A 267
PHE A 268
THR A  32
 None
 1.05A 3ag2N-1luaA:
0.0
3ag2W-1luaA:
0.0		 3ag2N-1luaA:
19.12
3ag2W-1luaA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		4 / 7 ILE A 264
LEU A 267
PHE A 268
THR A  32
 None
 1.05A 3ag4N-1luaA:
0.0
3ag4W-1luaA:
0.0		 3ag4N-1luaA:
19.12
3ag4W-1luaA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		5 / 9 LEU A 126
ILE A 252
GLY A 248
ILE A 232
VAL A 193
 None
 1.15A 3d1yB-1luaA:
undetectable		 3d1yB-1luaA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		5 / 11 GLY A 228
ASP A 220
ALA A 249
ARG A 183
ALA A 127
 None
None
None
NAP  A 456 ( 4.7A)
NAP  A 456 (-3.6A)
 1.09A 3g88A-1luaA:
6.8		 3g88A-1luaA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		5 / 11 GLY A 228
ASP A 220
ALA A 249
ARG A 183
ALA A 127
 None
None
None
NAP  A 456 ( 4.7A)
NAP  A 456 (-3.6A)
 1.10A 3g88B-1luaA:
7.2		 3g88B-1luaA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		5 / 12 GLY A 228
ASP A 220
ALA A 249
ARG A 183
ALA A 127
 None
None
None
NAP  A 456 ( 4.7A)
NAP  A 456 (-3.6A)
 1.09A 3g89A-1luaA:
7.2		 3g89A-1luaA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		5 / 11 GLY A 228
ASP A 220
ALA A 249
ARG A 183
ALA A 127
 None
None
None
NAP  A 456 ( 4.7A)
NAP  A 456 (-3.6A)
 1.10A 3g89B-1luaA:
7.2		 3g89B-1luaA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		5 / 12 PHE A 194
VAL A 124
PRO A 205
ILE A 215
VAL A 187
 None
 1.20A 3iw1A-1luaA:
undetectable		 3iw1A-1luaA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		5 / 12 ILE A 280
CYH A 263
LEU A 259
PHE A  64
SER A  16
 None
 1.26A 3ko0A-1luaA:
undetectable
3ko0B-1luaA:
0.0
3ko0C-1luaA:
undetectable
3ko0D-1luaA:
undetectable		 3ko0A-1luaA:
15.25
3ko0B-1luaA:
15.25
3ko0C-1luaA:
15.25
3ko0D-1luaA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		5 / 12 SER A  16
PHE A  64
ILE A 280
CYH A 263
LEU A 259
 None
 1.23A 3ko0G-1luaA:
0.0
3ko0H-1luaA:
undetectable
3ko0I-1luaA:
0.0
3ko0J-1luaA:
0.0		 3ko0G-1luaA:
15.25
3ko0H-1luaA:
15.25
3ko0I-1luaA:
15.25
3ko0J-1luaA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		5 / 12 LEU A 259
ILE A 280
CYH A 263
SER A  16
PHE A  64
 None
 1.17A 3ko0K-1luaA:
0.0
3ko0L-1luaA:
undetectable
3ko0M-1luaA:
0.0
3ko0N-1luaA:
undetectable		 3ko0K-1luaA:
15.25
3ko0L-1luaA:
15.25
3ko0M-1luaA:
15.25
3ko0N-1luaA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_H_P77H203_1
(PROTEIN S100-A4)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		5 / 10 LEU A 259
ILE A 280
CYH A 263
PHE A  64
SER A  16
 None
 1.26A 3m0wE-1luaA:
undetectable
3m0wF-1luaA:
undetectable
3m0wG-1luaA:
undetectable
3m0wH-1luaA:
undetectable		 3m0wE-1luaA:
15.25
3m0wF-1luaA:
15.25
3m0wG-1luaA:
15.25
3m0wH-1luaA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_I_P77I203_1
(PROTEIN S100-A4)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		5 / 10 LEU A 259
ILE A 280
CYH A 263
SER A  16
PHE A  64
 None
 1.24A 3m0wA-1luaA:
undetectable
3m0wB-1luaA:
undetectable
3m0wI-1luaA:
undetectable
3m0wJ-1luaA:
undetectable		 3m0wA-1luaA:
15.25
3m0wB-1luaA:
15.25
3m0wI-1luaA:
15.25
3m0wJ-1luaA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		4 / 5 ASP A  69
GLU A  74
GLY A  73
ASP A  12
 None
 1.19A 3w9tD-1luaA:
0.0		 3w9tD-1luaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		4 / 4 ASP A  95
LEU A  94
ARG A 167
THR A 101
 None
 1.44A 4kjjA-1luaA:
undetectable		 4kjjA-1luaA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		4 / 4 ASP A  95
LEU A  94
ARG A 167
THR A 101
 None
 1.42A 4kjkA-1luaA:
undetectable		 4kjkA-1luaA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		4 / 5 ASP A  95
LEU A  94
ARG A 167
THR A 101
 None
 1.41A 4p3qA-1luaA:
undetectable		 4p3qA-1luaA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		5 / 11 ALA A 104
ASP A 220
TYR A 221
GLY A 254
GLY A 248
 None
 1.25A 4xp4A-1luaA:
0.0		 4xp4A-1luaA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		4 / 6 ILE A 264
LEU A 267
PHE A 268
THR A  32
 None
 1.05A 5b1aN-1luaA:
0.0
5b1aW-1luaA:
0.0		 5b1aN-1luaA:
19.12
5b1aW-1luaA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		4 / 8 VAL A 132
ALA A 103
GLY A 106
GLY A 253
 NAP  A 456 (-3.9A)
None
None
None
 0.80A 5e26C-1luaA:
0.7
5e26D-1luaA:
undetectable		 5e26C-1luaA:
23.56
5e26D-1luaA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		3 / 3 MET A  93
HIS A 260
GLY A  66
 None
 0.70A 5gwzB-1luaA:
0.8		 5gwzB-1luaA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		5 / 12 VAL A 172
GLU A 176
ALA A 159
ALA A 160
VAL A 164
 None
 1.42A 5igpA-1luaA:
0.0		 5igpA-1luaA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		5 / 12 ILE A 252
GLY A 248
GLU A 143
ALA A 196
ILE A 217
 None
None
None
NAP  A 456 (-4.7A)
None
 1.07A 5ih0A-1luaA:
undetectable		 5ih0A-1luaA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		4 / 5 ILE A 215
SER A 214
ALA A 186
LEU A 204
 None
 1.03A 6dwnA-1luaA:
0.0		 6dwnA-1luaA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE
(Methylobacterium
extorquens) 		3 / 3 LYS A  56
SER A 271
SER A 270
 None
 1.06A 6gbfA-1luaA:
3.6		 6gbfA-1luaA:
25.17