SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lv2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 1lv2 HEPATOCYTE NUCLEAR
FACTOR 4-GAMMA
(Homo
sapiens) 		5 / 11 ARG A 217
ILE A 297
THR A 184
LEU A 222
THR A 293
 None
 1.36A 3bf1E-1lv2A:
undetectable
3bf1F-1lv2A:
undetectable		 3bf1E-1lv2A:
23.38
3bf1F-1lv2A:
23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1lv2 HEPATOCYTE NUCLEAR
FACTOR 4-GAMMA
(Homo
sapiens) 		5 / 12 CYH A 139
GLN A 145
LEU A 179
ARG A 186
LEU A 196
 None
PLM  A 328 ( 4.8A)
PLM  A 328 ( 4.6A)
PLM  A 328 (-3.3A)
PLM  A 328 (-3.7A)
 0.78A 3fc6C-1lv2A:
23.9		 3fc6C-1lv2A:
39.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 1lv2 HEPATOCYTE NUCLEAR
FACTOR 4-GAMMA
(Homo
sapiens) 		5 / 12 LEU A 222
GLY A 182
ALA A 183
VAL A 138
ILE A 297
 None
None
PLM  A 328 ( 3.9A)
None
None
 0.87A 3s54A-1lv2A:
undetectable		 3s54A-1lv2A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1lv2 HEPATOCYTE NUCLEAR
FACTOR 4-GAMMA
(Homo
sapiens) 		3 / 3 ASP A 279
GLU A 286
GLY A 282
 None
 0.67A 3w9tA-1lv2A:
0.0		 3w9tA-1lv2A:
18.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1lv2 HEPATOCYTE NUCLEAR
FACTOR 4-GAMMA
(Homo
sapiens) 		5 / 12 GLN A 145
LEU A 179
ARG A 186
LEU A 196
VAL A 218
 PLM  A 328 ( 4.8A)
PLM  A 328 ( 4.6A)
PLM  A 328 (-3.3A)
PLM  A 328 (-3.7A)
None
 0.71A 4k6iA-1lv2A:
27.9		 4k6iA-1lv2A:
40.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 1lv2 HEPATOCYTE NUCLEAR
FACTOR 4-GAMMA
(Homo
sapiens) 		3 / 3 ARG A 283
LEU A 287
GLU A 286
 None
 0.70A 4l3gF-1lv2A:
0.0		 4l3gF-1lv2A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 1lv2 HEPATOCYTE NUCLEAR
FACTOR 4-GAMMA
(Homo
sapiens) 		4 / 7 ALA A 133
LEU A 196
LEU A 195
ILE A 132
 None
PLM  A 328 (-3.7A)
None
None
 0.74A 4ubsA-1lv2A:
undetectable		 4ubsA-1lv2A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 1lv2 HEPATOCYTE NUCLEAR
FACTOR 4-GAMMA
(Homo
sapiens) 		5 / 12 ILE A 305
VAL A 138
LEU A 324
LEU A 179
LEU A 146
 PLM  A 328 (-4.5A)
None
None
PLM  A 328 ( 4.6A)
None
 1.26A 5tiwA-1lv2A:
undetectable		 5tiwA-1lv2A:
21.13