SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lva'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 1lva SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Moorella
thermoacetica) 		4 / 8 SER A 589
PHE A 593
ALA A 598
LEU A 613
 None
 0.92A 2bxkA-1lvaA:
0.0		 2bxkA-1lvaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 1lva SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Moorella
thermoacetica) 		4 / 8 SER A 589
PHE A 593
ALA A 598
LEU A 613
 None
 0.83A 2bxmA-1lvaA:
0.4		 2bxmA-1lvaA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1lva SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Moorella
thermoacetica) 		3 / 3 ASP A 617
ARG A 623
ARG A 624
 None
 1.10A 2j9dA-1lvaA:
0.0
2j9dC-1lvaA:
0.1		 2j9dA-1lvaA:
18.99
2j9dC-1lvaA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1lva SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Moorella
thermoacetica) 		3 / 3 LEU A 464
LEU A 451
ARG A 449
 None
 0.74A 3hcnB-1lvaA:
undetectable		 3hcnB-1lvaA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 1lva SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Moorella
thermoacetica) 		4 / 4 LEU A 577
ILE A 584
GLY A 578
PHE A 621
 None
 1.03A 4dc3A-1lvaA:
undetectable		 4dc3A-1lvaA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 1lva SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Moorella
thermoacetica) 		5 / 12 LYS A 412
LEU A 414
MET A 417
ALA A 403
ILE A 387
 None
 1.16A 4x1iD-1lvaA:
undetectable		 4x1iD-1lvaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 1lva SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Moorella
thermoacetica) 		5 / 11 PHE A 593
ALA A 588
LEU A 613
LEU A 616
PHE A 621
 None
 1.12A 4zmeA-1lvaA:
undetectable		 4zmeA-1lvaA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 1lva SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Moorella
thermoacetica) 		5 / 10 PHE A 593
ALA A 588
LEU A 577
LEU A 616
PHE A 621
 None
 1.27A 4zmeB-1lvaA:
undetectable		 4zmeB-1lvaA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 1lva SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Moorella
thermoacetica) 		5 / 10 PHE A 593
ALA A 588
LEU A 613
LEU A 616
PHE A 621
 None
 1.12A 4zmeB-1lvaA:
undetectable		 4zmeB-1lvaA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1lva SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Moorella
thermoacetica) 		5 / 12 LEU A 518
LYS A 517
LYS A 520
TYR A 526
LEU A 553
 None
 1.49A 5cyqA-1lvaA:
0.2		 5cyqA-1lvaA:
20.68