SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lvg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		4 / 7 ARG A  44
ASP A 103
TYR A  53
ARG A  41
 5GP  A1202 (-3.1A)
5GP  A1202 (-3.8A)
5GP  A1202 (-4.5A)
5GP  A1202 (-3.8A)
 1.37A 1cebA-1lvgA:
undetectable		 1cebA-1lvgA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4004_1
(SERUM ALBUMIN)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		4 / 4 VAL A   8
PHE A 165
SER A  10
VAL A 102
 None
None
None
5GP  A1202 (-3.7A)
 1.46A 1e7cA-1lvgA:
undetectable		 1e7cA-1lvgA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		4 / 4 GLY A  82
GLU A  72
ASP A 101
TYR A  53
 5GP  A1202 (-3.2A)
5GP  A1202 (-2.9A)
5GP  A1202 ( 3.4A)
5GP  A1202 (-4.5A)
 1.06A 2yvlC-1lvgA:
undetectable		 2yvlC-1lvgA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		3 / 3 SER A  10
GLU A 157
ASP A 103
 None
None
5GP  A1202 (-3.8A)
 0.79A 2zthA-1lvgA:
undetectable		 2zthA-1lvgA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		3 / 3 SER A  10
GLU A 157
ASP A 103
 None
None
5GP  A1202 (-3.8A)
 0.80A 3bwmA-1lvgA:
undetectable		 3bwmA-1lvgA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		3 / 3 SER A  10
GLU A 157
ASP A 103
 None
None
5GP  A1202 (-3.8A)
 0.81A 3bwyA-1lvgA:
undetectable		 3bwyA-1lvgA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		4 / 5 LEU A 149
GLN A 132
LEU A 134
GLU A 131
 None
 1.16A 3h5gA-1lvgA:
undetectable
3h5gB-1lvgA:
undetectable		 3h5gA-1lvgA:
12.20
3h5gB-1lvgA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		4 / 8 GLY A 106
CYH A  98
PHE A  32
PHE A  25
 5GP  A1202 (-3.2A)
None
None
None
 1.05A 3ko0B-1lvgA:
0.0
3ko0J-1lvgA:
0.0		 3ko0B-1lvgA:
20.83
3ko0J-1lvgA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		4 / 7 GLY A 106
CYH A  98
PHE A  32
PHE A  25
 5GP  A1202 (-3.2A)
None
None
None
 1.08A 3ko0L-1lvgA:
undetectable
3ko0N-1lvgA:
undetectable		 3ko0L-1lvgA:
20.83
3ko0N-1lvgA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		4 / 7 GLY A 106
CYH A  98
PHE A  32
PHE A  25
 5GP  A1202 (-3.2A)
None
None
None
 1.12A 3ko0R-1lvgA:
0.0
3ko0T-1lvgA:
undetectable		 3ko0R-1lvgA:
20.83
3ko0T-1lvgA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		3 / 3 LEU A  20
ASP A 101
ILE A 170
 None
5GP  A1202 ( 3.4A)
None
 0.61A 4xi3D-1lvgA:
undetectable		 4xi3D-1lvgA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		3 / 3 SER A  10
GLU A 157
ASP A 103
 None
None
5GP  A1202 (-3.8A)
 0.77A 4xudA-1lvgA:
undetectable		 4xudA-1lvgA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		4 / 7 ARG A  44
TYR A  81
GLU A  47
ASP A  52
 5GP  A1202 (-3.1A)
5GP  A1202 (-3.8A)
None
None
 1.13A 4zz8A-1lvgA:
0.0		 4zz8A-1lvgA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		4 / 6 ILE A 118
TYR A 119
PHE A 165
THR A  83
 None
None
None
5GP  A1202 (-4.2A)
 1.24A 5g08A-1lvgA:
undetectable		 5g08A-1lvgA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		5 / 12 LEU A 174
VAL A 122
LEU A   9
GLY A  11
PRO A  12
 ADP  A1201 (-3.7A)
None
None
None
None
 0.87A 5ienA-1lvgA:
0.0		 5ienA-1lvgA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		4 / 6 GLU A  47
ARG A  44
ASP A  49
ASP A 101
 None
5GP  A1202 (-3.1A)
None
5GP  A1202 ( 3.4A)
 1.17A 5zw4A-1lvgA:
undetectable		 5zw4A-1lvgA:
24.59