SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lvw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 ILE A  52
ASP A 108
LEU A 106
GLY A 107
 None
TYD  A3001 ( 2.9A)
TYD  A3001 (-3.4A)
TYD  A3001 (-4.1A)
 0.92A 2tsrB-1lvwA:
undetectable		 2tsrB-1lvwA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 LEU A  38
ILE A  46
ALA A  44
GLY A 172
LEU A 173
 None
 1.12A 2v0mB-1lvwA:
0.0		 2v0mB-1lvwA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A  38
VAL A 102
TYR A 176
ILE A  51
ILE A  91
 None
 0.99A 3frqB-1lvwA:
0.1		 3frqB-1lvwA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 PHE A  96
PHE A  75
SER A  76
TYR A  77
 None
 1.46A 3hggA-1lvwA:
undetectable		 3hggA-1lvwA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A 107
LEU A   6
GLN A  24
ASP A  57
SER A  53
 TYD  A3001 (-4.1A)
TYD  A3001 (-3.5A)
TYD  A3001 (-3.5A)
None
None
 1.07A 3tbgA-1lvwA:
undetectable		 3tbgA-1lvwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A 107
LEU A   6
GLN A  24
ASP A  57
SER A  53
 TYD  A3001 (-4.1A)
TYD  A3001 (-3.5A)
TYD  A3001 (-3.5A)
None
None
 1.04A 3tbgB-1lvwA:
0.0		 3tbgB-1lvwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A 107
LEU A   6
GLN A  24
ASP A  57
SER A  53
 TYD  A3001 (-4.1A)
TYD  A3001 (-3.5A)
TYD  A3001 (-3.5A)
None
None
 1.05A 3tbgC-1lvwA:
0.0		 3tbgC-1lvwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A 134
VAL A 180
TYR A 176
ASN A 201
VAL A 200
 None
None
None
CL  A4001 (-4.3A)
None
 1.41A 4ffwA-1lvwA:
undetectable		 4ffwA-1lvwA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 LEU A  38
PRO A  37
LEU A  41
ILE A  49
 None
 1.02A 4klrA-1lvwA:
2.3		 4klrA-1lvwA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ALA A  87
PHE A  96
GLY A  98
GLY A   3
VAL A 102
 None
 0.97A 5i73A-1lvwA:
undetectable		 5i73A-1lvwA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 ARG A  78
LEU A  50
ILE A 197
GLY A  85
ILE A   4
 None
None
None
TYD  A3001 (-3.5A)
None
 1.04A 5kr1A-1lvwA:
undetectable		 5kr1A-1lvwA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 7 GLY A 172
LEU A 106
LEU A  50
ILE A  86
ILE A  97
 None
TYD  A3001 (-3.4A)
None
None
None
 1.17A 5vkqA-1lvwA:
undetectable
5vkqB-1lvwA:
undetectable		 5vkqA-1lvwA:
9.76
5vkqB-1lvwA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 7 GLY A 172
LEU A 106
LEU A  50
ILE A 197
ILE A  97
 None
TYD  A3001 (-3.4A)
None
None
None
 1.24A 5vkqA-1lvwA:
undetectable
5vkqB-1lvwA:
undetectable		 5vkqA-1lvwA:
9.76
5vkqB-1lvwA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 8 GLY A 172
LEU A 106
LEU A  50
ILE A  86
ILE A  97
 None
TYD  A3001 (-3.4A)
None
None
None
 1.18A 5vkqB-1lvwA:
undetectable
5vkqC-1lvwA:
undetectable		 5vkqB-1lvwA:
9.76
5vkqC-1lvwA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 8 GLY A 172
LEU A 106
LEU A  50
ILE A 197
ILE A  97
 None
TYD  A3001 (-3.4A)
None
None
None
 1.21A 5vkqB-1lvwA:
undetectable
5vkqC-1lvwA:
undetectable		 5vkqB-1lvwA:
9.76
5vkqC-1lvwA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 PRO A  37
TYR A  36
LEU A  65
VAL A   5
 None
 0.87A 5x80A-1lvwA:
0.0
5x80B-1lvwA:
0.0		 5x80A-1lvwA:
21.89
5x80B-1lvwA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 ILE A 183
ALA A  87
ILE A 157
ARG A 206
TYR A 176
 None
None
CL  A4001 ( 4.4A)
SO4  A5001 (-3.1A)
None
 1.30A 5z6fA-1lvwA:
undetectable		 5z6fA-1lvwA:
20.27