SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lw7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1lw7 TRANSCRIPTIONAL
REGULATOR NADR
(Haemophilus
influenzae) 		5 / 12 LEU A  88
VAL A  60
SER A 190
VAL A  90
HIS A 135
 None
 1.39A 1ie9A-1lw7A:
0.0		 1ie9A-1lw7A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1lw7 TRANSCRIPTIONAL
REGULATOR NADR
(Haemophilus
influenzae) 		5 / 7 LEU A  88
GLY A  73
ILE A  75
VAL A  90
ILE A  63
 None
NAD  A 601 ( 4.2A)
None
None
None
 1.35A 2aojB-1lw7A:
undetectable		 2aojB-1lw7A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 1lw7 TRANSCRIPTIONAL
REGULATOR NADR
(Haemophilus
influenzae) 		4 / 6 VAL A 243
HIS A 286
TYR A 289
ASN A 244
 None
None
NAD  A 605 (-3.3A)
SO4  A 607 (-4.0A)
 1.36A 2zs9A-1lw7A:
4.2		 2zs9A-1lw7A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 1lw7 TRANSCRIPTIONAL
REGULATOR NADR
(Haemophilus
influenzae) 		5 / 12 GLU A  87
PHE A 165
LYS A 163
ILE A  91
LEU A 159
 None
 1.31A 3ia4C-1lw7A:
undetectable		 3ia4C-1lw7A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1lw7 TRANSCRIPTIONAL
REGULATOR NADR
(Haemophilus
influenzae) 		5 / 12 ASP A  99
SER A 106
PHE A 225
ARG A 119
PRO A  69
 None
 1.29A 3j6pB-1lw7A:
4.5		 3j6pB-1lw7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 1lw7 TRANSCRIPTIONAL
REGULATOR NADR
(Haemophilus
influenzae) 		4 / 5 ARG A 117
PRO A  69
TYR A  68
VAL A  70
 None
 1.40A 3sufC-1lw7A:
undetectable		 3sufC-1lw7A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 1lw7 TRANSCRIPTIONAL
REGULATOR NADR
(Haemophilus
influenzae) 		5 / 12 LEU A 339
LEU A 367
LEU A 370
GLN A 311
THR A 337
 None
 1.28A 3zqtA-1lw7A:
undetectable		 3zqtA-1lw7A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1lw7 TRANSCRIPTIONAL
REGULATOR NADR
(Haemophilus
influenzae) 		3 / 3 LEU A 367
ASP A 372
ILE A 231
 None
 0.53A 4xi3D-1lw7A:
undetectable		 4xi3D-1lw7A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1lw7 TRANSCRIPTIONAL
REGULATOR NADR
(Haemophilus
influenzae) 		4 / 5 TYR A 181
PHE A 165
LEU A 137
PRO A 167
 None
 1.43A 5csyB-1lw7A:
undetectable		 5csyB-1lw7A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1lw7 TRANSCRIPTIONAL
REGULATOR NADR
(Haemophilus
influenzae) 		4 / 8 TYR A 181
LEU A 185
ILE A 169
PHE A 160
 None
 0.81A 5eseA-1lw7A:
undetectable		 5eseA-1lw7A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1lw7 TRANSCRIPTIONAL
REGULATOR NADR
(Haemophilus
influenzae) 		5 / 12 ASP A  99
SER A 106
PHE A 225
ARG A 119
PRO A  69
 None
 1.42A 5hnzB-1lw7A:
3.2		 5hnzB-1lw7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1lw7 TRANSCRIPTIONAL
REGULATOR NADR
(Haemophilus
influenzae) 		4 / 5 LYS A 368
LEU A 339
GLU A 380
TYR A 378
 None
 1.40A 5js1A-1lw7A:
2.1		 5js1A-1lw7A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 1lw7 TRANSCRIPTIONAL
REGULATOR NADR
(Haemophilus
influenzae) 		3 / 3 ARG A 110
PRO A 223
TYR A 332
 None
 0.81A 5tzoB-1lw7A:
undetectable		 5tzoB-1lw7A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1lw7 TRANSCRIPTIONAL
REGULATOR NADR
(Haemophilus
influenzae) 		3 / 3 ARG A 389
ILE A 381
SER A 383
 None
 0.83A 5zw2A-1lw7A:
undetectable		 5zw2A-1lw7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1lw7 TRANSCRIPTIONAL
REGULATOR NADR
(Haemophilus
influenzae) 		4 / 7 GLY A  65
PHE A  67
HIS A  74
SER A 202
 NAD  A 601 (-3.6A)
None
NAD  A 601 (-4.5A)
SO4  A 501 (-2.5A)
 0.49A 6jnhA-1lw7A:
14.5		 6jnhA-1lw7A:
20.33