SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lwd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 PHE A 197
ALA A 268
PHE A 239
TYR A 208
GLN A 257
 None
 1.40A 1brpA-1lwdA:
0.2		 1brpA-1lwdA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		5 / 11 ILE A 330
GLU A 341
ILE A 113
VAL A 367
PHE A 398
 None
 1.23A 1gx9A-1lwdA:
undetectable		 1gx9A-1lwdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		4 / 4 HIS A 194
ALA A 193
PHE A 192
GLY A 191
 None
 1.22A 1mj2B-1lwdA:
undetectable		 1mj2B-1lwdA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		4 / 4 HIS A 194
ALA A 193
PHE A 192
GLY A 191
 None
 1.24A 1mj2D-1lwdA:
undetectable		 1mj2D-1lwdA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		4 / 4 HIS A 194
ALA A 193
PHE A 192
GLY A 191
 None
 1.23A 1mjoB-1lwdA:
undetectable		 1mjoB-1lwdA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 395
LEU A 399
LEU A 406
 None
 0.56A 1mz9C-1lwdA:
undetectable		 1mz9C-1lwdA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 GLY A 263
SER A 262
GLY A 124
VAL A 266
ILE A 131
 None
 1.03A 2b25B-1lwdA:
undetectable		 2b25B-1lwdA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		4 / 6 ARG A 101
ASP A 279
SER A 278
SER A 293
 ICT  A 701 ( 3.0A)
MN  A 501 (-4.0A)
None
None
 0.98A 2j2pD-1lwdA:
undetectable
2j2pF-1lwdA:
0.0		 2j2pD-1lwdA:
19.66
2j2pF-1lwdA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		4 / 5 PHE A 227
PRO A 298
VAL A 258
PHE A 109
 None
 1.25A 2ygnA-1lwdA:
undetectable		 2ygnA-1lwdA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 SER A 278
GLU A 306
ASP A 275
 None
ICT  A 701 ( 4.2A)
MN  A 501 (-2.8A)
 0.61A 2zthA-1lwdA:
2.6		 2zthA-1lwdA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 SER A 278
GLU A 306
ASP A 275
 None
ICT  A 701 ( 4.2A)
MN  A 501 (-2.8A)
 0.66A 3bwmA-1lwdA:
2.2		 3bwmA-1lwdA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 SER A 278
GLU A 306
ASP A 275
 None
ICT  A 701 ( 4.2A)
MN  A 501 (-2.8A)
 0.64A 3bwyA-1lwdA:
2.7		 3bwyA-1lwdA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 CYH A 196
HIS A 194
PHE A 197
 None
 1.14A 3cr4X-1lwdA:
undetectable		 3cr4X-1lwdA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		4 / 6 VAL A   7
LEU A 406
ILE A  27
LEU A 352
 None
 0.78A 3kk6A-1lwdA:
undetectable		 3kk6A-1lwdA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		4 / 6 VAL A   7
LEU A 406
ILE A  27
LEU A 352
 None
 0.77A 3kk6B-1lwdA:
undetectable		 3kk6B-1lwdA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		4 / 6 ASP A  15
GLY A  46
ASP A  17
THR A  76
 None
 0.89A 3vqrA-1lwdA:
undetectable		 3vqrA-1lwdA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		4 / 5 ASP A  15
GLY A  46
ASP A  17
THR A  76
 None
 0.91A 3vqrB-1lwdA:
undetectable		 3vqrB-1lwdA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		4 / 6 ASP A 279
ASP A 275
SER A  95
ALA A 308
 MN  A 501 (-4.0A)
MN  A 501 (-2.8A)
ICT  A 701 ( 2.4A)
ICT  A 701 ( 4.2A)
 1.23A 4nedA-1lwdA:
undetectable		 4nedA-1lwdA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 SER A  69
ALA A  71
VAL A  72
 None
 0.69A 4o2bC-1lwdA:
undetectable		 4o2bC-1lwdA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 SER A 278
GLU A 306
ASP A 275
 None
ICT  A 701 ( 4.2A)
MN  A 501 (-2.8A)
 0.66A 4xudA-1lwdA:
2.2		 4xudA-1lwdA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		5 / 11 VAL A  38
VAL A   7
ILE A 303
TRP A 336
LEU A 340
 None
 1.10A 5e4dB-1lwdA:
0.0		 5e4dB-1lwdA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 ARG A  50
THR A  76
ASP A  17
 None
 0.94A 5g5gA-1lwdA:
0.0
5g5gB-1lwdA:
0.0		 5g5gA-1lwdA:
20.59
5g5gB-1lwdA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 LYS A 116
LEU A 376
ILE A 113
 None
 0.56A 5kc0A-1lwdA:
3.2		 5kc0A-1lwdA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 LYS A 116
LEU A 376
ILE A 113
 None
 0.67A 5kc4A-1lwdA:
undetectable		 5kc4A-1lwdA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 HIS A 134
LYS A 270
PHE A 223
 None
 1.27A 5klaA-1lwdA:
0.4		 5klaA-1lwdA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 1lwd ISOCITRATE
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 GLY A 105
LEU A 104
ASP A 186
ILE A 189
ASN A 102
 None
 0.83A 6mhtA-1lwdA:
undetectable		 6mhtA-1lwdA:
22.02