SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lxt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		5 / 10 LEU A 391
ALA A  97
ILE A 112
GLY A  60
PHE A 286
 None
 1.16A 1d4sA-1lxtA:
undetectable		 1d4sA-1lxtA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		5 / 8 LEU A 391
ALA A  97
GLY A  60
ILE A  92
PHE A 286
 None
 1.14A 1d4sB-1lxtA:
undetectable		 1d4sB-1lxtA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		4 / 6 GLU A 375
THR A 354
ALA A 331
LEU A 372
 None
 1.11A 1etb2-1lxtA:
undetectable		 1etb2-1lxtA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		4 / 6 HIS A 259
ASP A 262
ASP A 287
PRO A 119
 None
None
CD  A 562 ( 2.8A)
None
 1.07A 1ilqA-1lxtA:
0.0
1ilqC-1lxtA:
undetectable		 1ilqA-1lxtA:
10.23
1ilqC-1lxtA:
3.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		4 / 8 GLY A 357
GLY A 379
SER A 377
GLY A 374
 None
 0.76A 1jhqA-1lxtA:
undetectable		 1jhqA-1lxtA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		5 / 12 VAL A 408
LEU A 401
SER A 399
LEU A 207
TRP A 392
 None
 1.43A 1mmkA-1lxtA:
undetectable		 1mmkA-1lxtA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		5 / 12 ILE A 128
LEU A  21
VAL A  27
ASP A 125
ALA A 115
 None
 1.00A 1r9oA-1lxtA:
0.0		 1r9oA-1lxtA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		5 / 10 GLY A  20
ILE A 142
ILE A 132
GLY A 110
ILE A 111
 None
 1.01A 1sh9B-1lxtA:
undetectable		 1sh9B-1lxtA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		5 / 11 ASN A 249
VAL A 232
GLY A 229
ALA A 247
ARG A 220
 None
 1.17A 2bxgA-1lxtA:
undetectable		 2bxgA-1lxtA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		4 / 6 LEU A 447
LEU A 491
MET A 448
GLU A 445
 None
 1.28A 2kuhA-1lxtA:
0.0		 2kuhA-1lxtA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		3 / 3 THR A 274
ASP A 281
SER A 407
 None
 0.78A 2nxeA-1lxtA:
2.4		 2nxeA-1lxtA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		3 / 3 THR A 274
ASP A 281
SER A 407
 None
 0.78A 2nxeB-1lxtA:
undetectable		 2nxeB-1lxtA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		5 / 12 ARG A 220
LEU A 271
ASP A 287
ASP A 262
GLY A 226
 None
None
CD  A 562 ( 2.8A)
None
None
 1.00A 2o4nA-1lxtA:
undetectable		 2o4nA-1lxtA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		3 / 3 ARG A 502
SER A 504
TYR A 516
 None
 1.00A 2q2hA-1lxtA:
0.0
2q2hB-1lxtA:
0.0		 2q2hA-1lxtA:
14.34
2q2hB-1lxtA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		4 / 6 VAL A 303
PHE A 378
THR A 380
TRP A 397
 None
 1.46A 2q6oB-1lxtA:
undetectable		 2q6oB-1lxtA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		5 / 8 ALA A  35
LEU A 113
ILE A  42
VAL A  58
ILE A  87
 None
 1.12A 2uxpA-1lxtA:
undetectable		 2uxpA-1lxtA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		5 / 8 GLU A  36
LEU A 113
ILE A  39
VAL A  58
ILE A  87
 None
 1.28A 2uxpA-1lxtA:
undetectable		 2uxpA-1lxtA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		4 / 6 LEU A 543
SER A 497
PHE A 493
ASP A 495
 None
 1.16A 2vn1B-1lxtA:
0.3		 2vn1B-1lxtA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		4 / 8 ILE A  42
PHE A  38
THR A 114
LEU A 113
 None
 0.80A 3abmN-1lxtA:
0.0
3abmW-1lxtA:
undetectable		 3abmN-1lxtA:
21.38
3abmW-1lxtA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		5 / 11 VAL A  57
LEU A  56
GLY A 109
ILE A 132
LYS A  15
 None
 1.18A 3bjwE-1lxtA:
undetectable		 3bjwE-1lxtA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		5 / 12 VAL A  57
LEU A  56
GLY A 109
ILE A 132
LYS A  15
 None
 1.14A 3bjwF-1lxtA:
undetectable		 3bjwF-1lxtA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		5 / 12 GLY A  91
GLY A  60
GLY A  62
ARG A  63
ILE A 187
 None
 1.02A 3ihtA-1lxtA:
undetectable		 3ihtA-1lxtA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		3 / 3 GLU A 521
PHE A 423
GLN A 529
 None
 0.65A 3r55A-1lxtA:
undetectable		 3r55A-1lxtA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		4 / 7 ILE A 149
LEU A  21
VAL A  27
SER A  31
 None
 1.00A 3r9vA-1lxtA:
undetectable
3r9vB-1lxtA:
undetectable		 3r9vA-1lxtA:
20.04
3r9vB-1lxtA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		5 / 11 LEU A 391
ALA A  97
ILE A 112
GLY A  60
ILE A  92
 None
 1.13A 3spkA-1lxtA:
undetectable		 3spkA-1lxtA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		5 / 12 GLY A 326
LEU A 364
GLY A 329
SER A 371
ALA A 367
 None
 0.98A 3sufA-1lxtA:
undetectable		 3sufA-1lxtA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		5 / 9 ASN A 363
GLY A 362
ASN A 134
SER A 482
ASP A 480
 None
 1.32A 3ztvA-1lxtA:
undetectable		 3ztvA-1lxtA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		4 / 6 PHE A 458
PHE A 493
ALA A 542
LEU A 444
 None
 1.00A 4ejgD-1lxtA:
0.0		 4ejgD-1lxtA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		3 / 3 TYR A 267
ARG A 292
HIS A 117
 None
SO4  A 563 (-3.8A)
None
 1.25A 4fubA-1lxtA:
0.0		 4fubA-1lxtA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		4 / 8 LEU A 391
VAL A 228
LEU A 207
LEU A 240
 None
 0.95A 4l1xA-1lxtA:
0.5		 4l1xA-1lxtA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		4 / 6 ASP A 291
ASP A 289
ASN A 118
ARG A  22
 CD  A 562 (-3.3A)
CD  A 562 ( 2.7A)
None
None
 1.24A 4ntxA-1lxtA:
0.0
4ntxC-1lxtA:
0.0		 4ntxA-1lxtA:
23.04
4ntxC-1lxtA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		4 / 6 SER A 484
TYR A 475
LYS A 359
PHE A 360
 None
 1.28A 5dlvA-1lxtA:
1.4		 5dlvA-1lxtA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		4 / 7 SER A 484
TYR A 475
LYS A 359
PHE A 360
 None
 1.26A 5dlvB-1lxtA:
0.4		 5dlvB-1lxtA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		3 / 3 LYS A 298
LEU A 412
ILE A 295
 None
 0.60A 5kc0A-1lxtA:
undetectable		 5kc0A-1lxtA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		3 / 3 LYS A 298
LEU A 412
ILE A 295
 None
 0.72A 5kc4A-1lxtA:
undetectable		 5kc4A-1lxtA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		4 / 8 ASP A 291
PRO A  96
TYR A 194
ASN A 293
 CD  A 562 (-3.3A)
None
None
None
 1.05A 5l1fA-1lxtA:
undetectable
5l1fB-1lxtA:
undetectable		 5l1fA-1lxtA:
22.85
5l1fB-1lxtA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		3 / 3 HIS A 260
HIS A 117
ARG A 292
 None
None
SO4  A 563 (-3.8A)
 1.10A 6b58A-1lxtA:
undetectable		 6b58A-1lxtA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		4 / 6 TYR A 465
ILE A 541
ALA A 536
MET A 534
 None
 1.15A 6hu9m-1lxtA:
0.0
6hu9q-1lxtA:
undetectable		 6hu9m-1lxtA:
23.42
6hu9q-1lxtA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)
(Oryctolagus
cuniculus) 		5 / 12 LEU A 370
THR A 356
ALA A 344
ASP A 341
LEU A 340
 None
 1.18A 6ie8A-1lxtA:
0.6		 6ie8A-1lxtA:
14.81