SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lyb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 1lyb CATHEPSIN D
(Homo
sapiens) 		4 / 7 HIS A  77
LEU A  83
SER A  84
ASP A  75
 None
 1.24A 1ismB-1lybA:
undetectable		 1ismB-1lybA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 1lyb CATHEPSIN D
(Homo
sapiens) 		4 / 7 THR A  23
ASN A  60
TYR A  59
GLN A  26
 None
 0.91A 1qzrB-1lybA:
undetectable		 1qzrB-1lybA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 1lyb CATHEPSIN D
(Homo
sapiens) 		6 / 12 GLN A  14
VAL A  31
ASP A  33
GLY A  35
SER A  36
TYR A  78
 None
 0.28A 2v0zC-1lybA:
10.6		 2v0zC-1lybA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 1lyb CATHEPSIN D
(Homo
sapiens) 		4 / 8 GLY A  35
SER A  36
ILE A  76
TYR A  78
 None
 0.36A 3pwwA-1lybA:
9.0		 3pwwA-1lybA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 1lyb CATHEPSIN D
(Homo
sapiens) 		5 / 9 GLY A  20
PHE A  28
SER A  64
GLY A  22
ASP A  90
 None
 1.32A 3ztvA-1lybA:
undetectable		 3ztvA-1lybA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1lyb CATHEPSIN D
(Homo
sapiens) 		4 / 8 ASP A  90
ILE A  21
GLY A  22
VAL A  30
 None
 0.70A 4acbB-1lybA:
undetectable
4acbC-1lybA:
undetectable		 4acbB-1lybA:
10.94
4acbC-1lybA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 1lyb CATHEPSIN D
(Homo
sapiens) 		4 / 5 THR A  66
THR A  91
ASP A  90
TYR A  59
 None
 1.25A 4oltA-1lybA:
undetectable		 4oltA-1lybA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 1lyb CATHEPSIN D
(Homo
sapiens) 		4 / 5 THR A  66
THR A  91
ASP A  90
TYR A  59
 None
 1.24A 4qwpB-1lybA:
undetectable		 4qwpB-1lybA:
19.26